Structure−Activity Relationships for Degradation Reaction of 1-β-O-Acyl Glucuronides: Kinetic Description and Prediction of Intrinsic Electrophilic Reactivity under Physiological Conditions

Akiko Baba; Tadao Yoshioka

doi:10.1021/tx800292m

Structure−Activity Relationships for Degradation Reaction of 1-β-O-Acyl Glucuronides: Kinetic Description and Prediction of Intrinsic Electrophilic Reactivity under Physiological Conditions

Chemical Research in Toxicology ◽

10.1021/tx800292m ◽

2009 ◽

Vol 22 (1) ◽

pp. 158-172 ◽

Cited By ~ 28

Author(s):

Akiko Baba ◽

Tadao Yoshioka

Keyword(s):

Kinetic Description ◽

Physiological Conditions ◽

Structure Activity Relationships ◽

Structure Activity ◽

Acyl Glucuronides ◽

Degradation Reaction ◽

Electrophilic Reactivity

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Structure−Activity Relationships for the Degradation Reaction of 1-β-O-Acyl Glucuronides. Part 3: Electronic and Steric Descriptors Predicting the Reactivity of Aralkyl Carboxylic Acid 1-β-O-Acyl Glucuronides

Chemical Research in Toxicology ◽

10.1021/tx9002963 ◽

2009 ◽

Vol 22 (12) ◽

pp. 1998-2008 ◽

Cited By ~ 23

Author(s):

Akiko Baba ◽

Tadao Yoshioka

Keyword(s):

Carboxylic Acid ◽

Structure Activity Relationships ◽

Structure Activity ◽

Acyl Glucuronides ◽

Degradation Reaction

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Structure−Activity Relationships for the Degradation Reaction of 1-β-O-Acyl Glucuronides. Part 2: Electronic and Steric Descriptors Predicting the Reactivity of 1-β-O-Acyl Glucuronides Derived from Benzoic Acids

Chemical Research in Toxicology ◽

10.1021/tx900092z ◽

2009 ◽

Vol 22 (9) ◽

pp. 1559-1569 ◽

Cited By ~ 17

Author(s):

Tadao Yoshioka ◽

Akiko Baba

Keyword(s):

Benzoic Acids ◽

Structure Activity Relationships ◽

Structure Activity ◽

Acyl Glucuronides ◽

Degradation Reaction

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Application of structure–activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity ofα,β‐unsaturated aldehydes

Journal of Applied Toxicology ◽

10.1002/jat.1369 ◽

2008 ◽

pp. n/a-n/a ◽

Cited By ~ 4

Author(s):

Katie Chan ◽

Raymond Poon ◽

Peter J. O'Brien

Keyword(s):

Molecular Mechanisms ◽

Structure Activity Relationships ◽

Unsaturated Aldehydes ◽

Structure Activity ◽

Electrophilic Reactivity ◽

Hepatocyte Toxicity

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Structure-Activity Relationships for Contact Allergenic Potential of .gamma.,.gamma.-Dimethyl-.gamma.-butyrolactone Derivatives. 1. Synthesis and Electrophilic Reactivity Studies of .alpha.-(.omega.-Substituted-alkyl)-.gamma.,.gamma.-dimethyl-.gamma.-butyrolactones and Correlation of Skin Sensitization Potential and Cross-Sensitization Patterns with Structure

Chemical Research in Toxicology ◽

10.1021/tx00039a005 ◽

1994 ◽

Vol 7 (3) ◽

pp. 297-306 ◽

Cited By ~ 21

Author(s):

Christelle Franot ◽

David W. Roberts ◽

Richard G. Smith ◽

David A. Basketter ◽

Claude Benezra ◽

...

Keyword(s):

Skin Sensitization ◽

Structure Activity Relationships ◽

Structure Activity ◽

Allergenic Potential ◽

Alpha Omega ◽

Electrophilic Reactivity ◽

Gamma Butyrolactone

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Structure-activity relationships for hepatocyte toxicity and electrophilic reactivity ofα,β-unsaturated esters, acrylates and methacrylates

Journal of Applied Toxicology ◽

10.1002/jat.1366 ◽

2008 ◽

Vol 28 (8) ◽

pp. 1004-1015 ◽

Cited By ~ 38

Author(s):

Katie Chan ◽

Peter J. O'Brien

Keyword(s):

Unsaturated Esters ◽

Structure Activity Relationships ◽

Structure Activity ◽

Electrophilic Reactivity ◽

Hepatocyte Toxicity

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Structure-Activity Relationships of MDMA-Like Substances

PsycEXTRA Dataset ◽

10.1037/e496472006-001 ◽

1989 ◽

Cited By ~ 3

Author(s):

David E. Nichols ◽

◽

Robert Oberlender

Keyword(s):

Structure Activity Relationships ◽

Structure Activity

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Structure-Activity Relationships in Cannabinoids: An Overview

PsycEXTRA Dataset ◽

10.1037/e496672006-002 ◽

1987 ◽

Author(s):

Raj K. Razdan ◽

Keyword(s):

Structure Activity Relationships ◽

Structure Activity

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Structure-Activity and Selectivity Relationships in Heterogeneous Catalysis, Proceedings of the ACS Symposium on Structure-Activity Relationships in Heterogeneous Catalysis

10.1016/s0167-2991(08)x6047-1 ◽

1991 ◽

Keyword(s):

Heterogeneous Catalysis ◽

Structure Activity Relationships ◽

Structure Activity

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Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽

10.1055/s-0028-1084761 ◽

2008 ◽

Vol 74 (09) ◽

Author(s):

Q Do ◽

H Doan Thi Mai ◽

T Gaslonde ◽

B Pfeiffer ◽

S Léonce ◽

...

Keyword(s):

Pyran Ring ◽

Structure Activity Relationships ◽

Structure Activity

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Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽

10.1055/s-0032-1320394 ◽

2012 ◽

Vol 78 (11) ◽

Author(s):

M Reis ◽

RJ Ferreira ◽

MMM Santos ◽

DJVA dos Santos ◽

J Molnár ◽

...

Keyword(s):

Structure Activity Relationships ◽

Structure Activity ◽

P Glycoprotein

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