scholarly journals Protein Targets of Reactive Metabolites of Thiobenzamide in Rat Liver in Vivo

2008 ◽  
Vol 21 (7) ◽  
pp. 1432-1442 ◽  
Author(s):  
Keisuke Ikehata ◽  
Tatyana G. Duzhak ◽  
Nadezhda A. Galeva ◽  
Tao Ji ◽  
Yakov M. Koen ◽  
...  
Keyword(s):  
Rat Liver ◽  
Reactive Metabolites ◽  
Protein Targets

Identification of Three Protein Targets for Reactive Metabolites of Bromobenzene in Rat Liver Cytosol

2000 ◽  
Vol 13 (12) ◽  
pp. 1326-1335 ◽  
Author(s):  
Yakov M. Koen ◽  
Todd D. Williams ◽  
Robert P. Hanzlik
Keyword(s):  
Rat Liver ◽  
Reactive Metabolites ◽  
Protein Targets ◽  
Liver Cytosol ◽  
Rat Liver Cytosol

Effect of X-irradiation on gene expression of rat liver chemokines: in vivo and in vitro studies

2008 ◽  
Vol 46 (01) ◽  
Author(s):  
F Moriconi ◽  
H Christiansen ◽  
H Christiansen ◽  
N Sheikh ◽  
J Dudas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
In Vitro Studies ◽  
X Irradiation

Chronic, in vivo, PPARα activation prevents lipid overload in rat liver induced by high fat feeding

2009 ◽  
Vol 54 (1) ◽  
Author(s):  
M Wierzbicki ◽  
A Chabowski ◽  
M Żendzian-Piotrowska ◽  
E Harasim ◽  
J Górski
Keyword(s):  
Rat Liver ◽  
High Fat ◽  
Fat Feeding

Conjugates of Classical DNA/RNA Binder with Nucleobase: Chemical, Biochemical and Biomedical Applications

2019 ◽  
Vol 26 (30) ◽  
pp. 5609-5624
Author(s):  
Dijana Saftić ◽  
Željka Ban ◽  
Josipa Matić ◽  
Lidija-Marija Tumirv ◽  
Ivo Piantanida
Keyword(s):  
Molecular Weight ◽  
Small Molecules ◽  
Biomedical Applications ◽  
Protein Targets ◽  
New Class ◽  
Rna Targets ◽  
Covalently Linked ◽  
Structural Aspects

: Among the most intensively studied classes of small molecules (molecular weight < 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA, and another intensively studied class is nucleobase derivatives. Both classes have been intensively elaborated in many books and reviews. However, conjugates consisting of DNA/RNA binder covalently linked to nucleobase are much less studied and have not been reviewed in the last two decades. Therefore, this review summarized reports on the design of classical DNA/RNA binder – nucleobase conjugates, as well as data about their interactions with various DNA or RNA targets, and even in some cases protein targets are involved. According to these data, the most important structural aspects of selective or even specific recognition between small molecule and target are proposed, and where possible related biochemical and biomedical aspects were discussed. The general conclusion is that this, rather new class of molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead research lines show promising advancements toward either novel, highly selective markers or bioactive, potentially druggable molecules.

scholarly journals Internalization and Activation of the Rat Liver Insulin Receptor Kinase in vivo

1989 ◽  
Vol 264 (22) ◽  
pp. 12931-12940 ◽  
Author(s):  
M N Khan ◽  
G Baquiran ◽  
C Brule ◽  
J Burgess ◽  
B Foster ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Rat Liver ◽  
Receptor Kinase ◽  
Insulin Receptor Kinase

scholarly journals The Metabolism of Intraportally Injected Fructose in Rat Liver in Vivo

1962 ◽  
Vol 237 (12) ◽  
pp. 3582-3587
Author(s):  
John A. Muntz ◽  
Michael Vanko
Keyword(s):  
Rat Liver
Sign in / Sign up

Export Citation Format

Share Document