scholarly journals Characterization of the Antiallergic Drugs 3-[2-(2-Phenylethyl) benzoimidazole-4-yl]-3-hydroxypropanoic Acid and Ethyl 3-Hydroxy-3-[2-(2-phenylethyl)benzoimidazol-4-yl]propanoate as Full Aryl Hydrocarbon Receptor Agonists

2008 ◽  
Vol 21 (2) ◽  
pp. 472-482 ◽  
Author(s):  
José Luis Morales ◽  
Jacek Krzeminski ◽  
Shantu Amin ◽  
Gary H. Perdew
2009 ◽  
Vol 43 (9) ◽  
pp. 2441-2448 ◽  
Author(s):  
Jianping Luo ◽  
Mei Ma ◽  
Jinmiao Zha ◽  
Zijian Wang

2020 ◽  
Vol 33 (3) ◽  
pp. 742-750
Author(s):  
Patrick Tarnow ◽  
Catrin Zordick ◽  
Alex Bottke ◽  
Berit Fischer ◽  
Friederike Kühne ◽  
...  

Molecules ◽  
2014 ◽  
Vol 19 (4) ◽  
pp. 4956-4966 ◽  
Author(s):  
Yoshiaki Amakura ◽  
Morio Yoshimura ◽  
Masashi Takaoka ◽  
Haruka Toda ◽  
Tomoaki Tsutsumi ◽  
...  

Author(s):  
V. N. Babakov ◽  
N. Yu. Rogovskaya ◽  
I. D. Kurdyukov ◽  
P. P. Beltyukov ◽  
S. A. Dulov ◽  
...  

The effect of aryl hydrocarbon receptor agonists (FICZ and ITE), as well as lipopolysaccharide under the toxic action of benzo(a)pyrene in HepaRG human hepatoma cells was evaluated. Active forms of the key stress-activated kinase cascades and DNA repair system proteins were used as markers of the genotoxic action of benzo(a)pyrene. A mixture of lipopolysaccharide with benzo(a)pyrene increases benzo(a)pyrene cytotoxicity and reduces the activation of DNA repair system proteins below the control level. Aryl hydrocarbon receptor agonists (FICZ and ITE) exhibit a cytoprotective effect against benzo(a) pyrene, enhance Akt1 kinase activation, and downregulate activation of the p53 protein and Chk1 and Chk2 checkpoint kinases. Thus, FICZ and ITE reduce the genotoxicity of benzo(a)pyrene.


Hepatology ◽  
2015 ◽  
Vol 61 (2) ◽  
pp. 548-560 ◽  
Author(s):  
Joshua A. Harrill ◽  
Bethany B Parks ◽  
Eliane Wauthier ◽  
J. Craig Rowlands ◽  
Lola M. Reid ◽  
...  

Ecotoxicology ◽  
2010 ◽  
Vol 19 (8) ◽  
pp. 1560-1566 ◽  
Author(s):  
J. A. Head ◽  
R. Farmahin ◽  
A. S. Kehoe ◽  
J. M. O’Brien ◽  
J. L. Shutt ◽  
...  

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