Pathways of Arachidonic Acid Peroxyl Radical Reactions and Product Formation with Guanine Radicals

2008 ◽  
Vol 21 (2) ◽  
pp. 358-373 ◽  
Author(s):  
Conor Crean ◽  
Nicholas E. Geacintov ◽  
Vladimir Shafirovich
Keyword(s):  
Arachidonic Acid ◽  
Peroxyl Radical ◽  
Product Formation ◽  
Radical Reactions

The effect of packed red blood cell storage on arachidonic acid and advanced glycation end-product formation

2006 ◽  
Vol 54 (5) ◽  
pp. 357-362 ◽  
Author(s):  
Lidia Łysenko ◽  
Magdalena Mierzchała ◽  
Andrzej Gamian ◽  
Grażyna Durek ◽  
Andrzej Kübler ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Product Formation ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Cell Storage

scholarly journals Protein thiyl radical reactions and product formation: a kinetic simulation

2015 ◽  
Vol 80 ◽  
pp. 158-163 ◽  
Author(s):  
Thomas Nauser ◽  
Willem H. Koppenol ◽  
Christian Schöneich
Keyword(s):  
Product Formation ◽  
Radical Reactions ◽  
Thiyl Radical ◽  
Kinetic Simulation

Further Studies of the Kinetics of Oxygenation of Arachidonic Acid by Soybean Lipoxygenase

1975 ◽  
Vol 53 (11) ◽  
pp. 1220-1231 ◽  
Author(s):  
H. W. Cook ◽  
W. E. M. Lands
Keyword(s):  
Experimental Data ◽  
Arachidonic Acid ◽  
Kinetic Model ◽  
Theoretical Data ◽  
Product Formation ◽  
Soybean Lipoxygenase ◽  
Product Removal ◽  
Velocity Changes ◽  
Extensive Experimental Data ◽  
Kinetics Of

A kinetic model for soybean lipoxygenase (EC 1.13.11.12) has been examined by comparing results from extensive experimental data with theoretical data generated from a computer program. Kinetic constants have been established by closely fitting experimental and computer-generated data with both product formation versus time, and the more complex accelerative and decelerative relationships of velocity changes with time.It has been confirmed that activation of lipoxygenase by its hydroperoxide product is necessary for activity, and product removal gives inhibition in a manner quantitatively predicted by the model. The earliest accurate measurement of velocity (at 9 s) is a convenient index of the amount of product–activator present in reaction mixtures, and can be used to assay quantitatively the amount of product–activator.The results confirm that soybean lipoxygenase catalyzes a product-activated, substrate-inhibited oxygenation accompanied by a self-catalyzed destruction of its activity.

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