scholarly journals Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease

2014 ◽  
Vol 27 (8) ◽  
pp. 1359-1361 ◽  
Author(s):  
John E. Casida ◽  
Breanna Ford ◽  
Yunden Jinsmaa ◽  
Patti Sullivan ◽  
Adele Cooney ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Aldehyde Dehydrogenase

Aldehyde dehydrogenase 2 in sporadic Parkinson's disease

2014 ◽  
Vol 20 ◽  
pp. S68-S72 ◽  
Author(s):  
Tanja Maria Michel ◽  
Ludwig Käsbauer ◽  
Wieland Gsell ◽  
Julia Jecel ◽  
Abigail Jane Sheldrick ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Aldehyde Dehydrogenase ◽  
Aldehyde Dehydrogenase 2 ◽  
Sporadic Parkinson’S Disease

In silico docking of Novel Phytoalkaloid Camalexin in the Management of Benomyl Induced Parkinson's disease and its In vivo Evaluation by Zebrafish Model

2021 ◽  
Vol 20 ◽  
Author(s):  
Tamilanban T ◽  
Manasa K ◽  
Chitra V
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Aldehyde Dehydrogenase ◽  
Neuronal Degeneration ◽  
In Vivo Model ◽  
Zebrafish Model ◽  
Standard Drug ◽  
In Silico Docking ◽  
Dehydrogenase Enzyme

Background: Parkinson’s disease (PD) exhibits the extra pyramidal symptoms caused due to the dopaminergic neuronal degeneration in the substantia nigra of the brain and depletion of aldehyde dehydrogenase (ALDH) enzyme. Objective: This study was designed to enlighten the importance of Aldehyde dehydrogenase enzyme in protecting the dopamine levels in a living system. Camalexin, a potentially active compound has been evaluated for its dopamine enhancing and aldehyde dehydrogenase protecting role in pesticide induced Parkinson’s disease. Methods: AutoDock 4.2 software was employed to perform the docking simulations between the ligand camalexin and standard drugs Alda-1, Ropirinole with three proteins 4WJR, 3INL, 5AER. Consequently, the compound was evaluated for its in vivo neuroprotective role in zebrafish model by attaining Institutional Animal Ethical Committee permission. The behavioral assessments and catecholamine analysis in zebrafish were performed. Results: The Autodock result shows that the ligand camalexin has a lower binding energy (-3.84) that indicate higher affinity with the proteins when compared to the standard drug of proteins (-3.42). In zebrafish model, behavioral studies provided an evidence that camalexin helps in improvement of motor functions and cognition. The catecholamine assay has proved there is an enhancement in dopamine levels, as well as an improvement in aldehyde dehydrogenase enzyme also. Conclusion: The novel compound, camalexin, hence offers a protective role in Parkinson’s disease model by its interaction with neurochemical proteins and also in alternative in vivo model.

scholarly journals Rotenone decreases intracellular aldehyde dehydrogenase activity: implications for the pathogenesis of Parkinson's disease

2015 ◽  
Vol 133 (1) ◽  
pp. 14-25 ◽  
Author(s):  
David S. Goldstein ◽  
Patti Sullivan ◽  
Adele Cooney ◽  
Yunden Jinsmaa ◽  
Irwin J. Kopin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Aldehyde Dehydrogenase Activity

scholarly journals Phytoconstituents in the Management of Pesticide Induced Parkinson’s Disease- A Review

2019 ◽  
Vol 12 (3) ◽  
pp. 1417-1424
Author(s):  
Manasa K ◽  
Chitra V
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Aldehyde Dehydrogenase ◽  
Chronic Exposure ◽  
Agricultural Fields ◽  
Pathological Changes ◽  
Land Area ◽  
Tropical Crops ◽  
Dehydrogenase Enzyme

Recent studies have suggested that environmental factors have a crucial role in triggering and/ or propagating the pathological changes in Parkinson’s disease (PD). Although many studies have been and being performed by utilizing MPTP like chemicals to study the effectiveness of new extracts and compounds in PD, a little focus was made on the role of pesticides. Since agricultural fields account for 37.7% of land area worldwide and the use of pesticides is an important risk factor in neurodegeneration, there is a crucial need to focus on the association between pesticides and PD. Benomyl, a benzimidazole fungicide is being widely used in India in cultivation of tropical crops. Studies prove the chronic exposure of benomyl leads to aldehyde dehydrogenase inhibition caused DOPAL toxicity, subsequently leading to dopamine degradation and Parkinson’s disease. Till date, there is no remedy for pesticide induced Parkinson’s disease. This review provides an insight of the pathophysiological aspects of pesticide induced Parkinson’s disease and also enlightens the importance of aldehyde dehydrogenase enzyme in neuroprotection.

DITHIOCARBAMATE PESTICIDE EXPOSURES, ALDEHYDE DEHYDROGENASE INHIBITION, AND RISK OF PARKINSON’S DISEASE

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Beate Ritz ◽  
Shannon L. Rhodes ◽  
Arthur G. Fitzmaurice ◽  
Myles Cockburn ◽  
Jeff M. Bronstein
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Aldehyde Dehydrogenase ◽  
Pesticide Exposures
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