Are Dinucleoside Monophosphates Relevant Models for the Study of DNA Intrastrand Cross-Link Lesions? The Example of G[8–5m]T

2014 ◽  
Vol 27 (7) ◽  
pp. 1133-1141 ◽  
Author(s):  
Julian Garrec ◽  
Elise Dumont
Keyword(s):  
Cross Link ◽  
Dinucleoside Monophosphates

Boron nitride for modification of rubber based on isoprene elastomer

2020 ◽  
pp. 105-112
Author(s):  
K. S. Zhansakova ◽  
E. N. Eremin ◽  
G. S. Russkikh ◽  
O. V. Kropotin
Keyword(s):  
Mechanical Properties ◽  
Boron Nitride ◽  
Gradual Increase ◽  
Physical And Mechanical Properties ◽  
Curing Time ◽  
Cross Link ◽  
Start Time ◽  
Link Density ◽  
Cross Link Density ◽  
Isoprene Rubber

The work studies vulcanization characteristics of elastomers based on isoprene rubber filled with carbon black N330 and boron nitride (BN). The influence of the boron nitride (BN) concentration on technological, dynamic, physical and mechanical properties of elastomers has been researched. The application of boron nitride for producing rubber with good properties has been considered. With a gradual increase of the inert filler BN concentration up to 35%, a decrease in the curing rate by 33% and polymer cross-link density by 26% is observed. Moreover, the start time of vulcanization increases by almost 300%, the optimal curing time by 200%.

Ribonuclease a catalyzed preparative synthesis of dinucleoside monophosphates containing uridine analogues

1980 ◽  
Vol 45 (2) ◽  
pp. 611-616 ◽  
Author(s):  
Antonina P. Kavunenko ◽  
Antonín Holý
Keyword(s):  
Paper Chromatography ◽  
Ribonuclease A ◽  
Uv Spectra ◽  
Preparative Synthesis ◽  
Cyclic Phosphate ◽  
Dinucleoside Monophosphates

Preparative synthesis of dinucleoside monophosphates, catalyzed by ribonuclease A, is described. Uridine 2',3' -cyclic phosphate was used as a donor, the acceptors being uridine (Ia), N3-methyl-uridine (Ib), 5-methyluridine (Ic), 6-methyluridine (Id), 3-(β-D-ribofuranosyl)uracil (IIa), 1-methyl-3-(β-D-ribofuranosyl)uracil (IIb), 6-azauridine (III) and 6-methyl-2'-deoxyuridine (IV). The obtained compounds of the type UpN (where N is the nucleoside moiety I-IV) were characterized by paper chromatography, electrophoresis and UV-spectra.

Mechanisms of DNA−protein cross-link formation and repair

2021 ◽  
pp. 140669
Author(s):  
Xiaoying Wei ◽  
Ying Peng ◽  
Cameron Bryan ◽  
Kun Yang
Keyword(s):  
Cross Link ◽  
Link Formation

scholarly journals LOXL2 Inhibitors and Breast Cancer Progression

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 312
Author(s):  
Sandra Ferreira ◽  
Nuno Saraiva ◽  
Patrícia Rijo ◽  
Ana S. Fernandes
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Cancer Biology ◽  
Breast Cancer Cells ◽  
Lysyl Oxidase ◽  
Breast Cancer Progression ◽  
Special Focus ◽  
Amine Oxidases ◽  
Cross Link ◽  
Promising Strategy

LOX (lysyl oxidase) and lysyl oxidase like-1–4 (LOXL 1–4) are amine oxidases, which catalyze cross-linking reactions of elastin and collagen in the connective tissue. These amine oxidases also allow the cross-link of collagen and elastin in the extracellular matrix of tumors, facilitating the process of cell migration and the formation of metastases. LOXL2 is of particular interest in cancer biology as it is highly expressed in some tumors. This protein also promotes oncogenic transformation and affects the proliferation of breast cancer cells. LOX and LOXL2 inhibition have thus been suggested as a promising strategy to prevent metastasis and invasion of breast cancer. BAPN (β-aminopropionitrile) was the first compound described as a LOX inhibitor and was obtained from a natural source. However, novel synthetic compounds that act as LOX/LOXL2 selective inhibitors or as dual LOX/LOX-L inhibitors have been recently developed. In this review, we describe LOX enzymes and their role in promoting cancer development and metastases, with a special focus on LOXL2 and breast cancer progression. Moreover, the recent advances in the development of LOXL2 inhibitors are also addressed. Overall, this work contextualizes and explores the importance of LOXL2 inhibition as a promising novel complementary and effective therapeutic approach for breast cancer treatment.

scholarly journals A natural histidine-based imminium cross-link in collagen and its location.

1980 ◽  
Vol 255 (21) ◽  
pp. 10414-10422
Author(s):  
P.H. Bernstein ◽  
G.L. Mechanic
Keyword(s):  
Cross Link
Sign in / Sign up

Export Citation Format

Share Document