N-Hydroxycinnamide Derivatives of Osthole Presenting Genotoxicity and Cytotoxicity against Human Colon Adenocarcinoma Cells in Vitro and in Vivo

2013 ◽  
Vol 26 (11) ◽  
pp. 1683-1691 ◽  
Author(s):  
Ling-Yu Liu ◽  
Wei-Jan Huang ◽  
Ren-Jye Lin ◽  
Shyr-Yi Lin ◽  
Yu-Chih Liang
Keyword(s):  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Adenocarcinoma Cells ◽  
Derivatives Of ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

scholarly journals Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 564
Author(s):  
Nayara Simas Frauches ◽  
Júlia Montenegro ◽  
Thuane Amaral ◽  
Joel Pimentel Abreu ◽  
Gabriela Laiber ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Native Plant ◽  
Total Anthocyanin ◽  
Adenocarcinoma Cells ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

There is a significant indication of the beneficial health effects of fruit rich diets. Fruits of native plant species have noticeably different phytochemicals and bioactive effects. The aim of this work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ), jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and their influence on antioxidant activity in vitro and antiproliferative effects on human colon adenocarcinoma cells. According to the results, dried peel powders (DP) have a high anthocyanin content, phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD). M. jaboticaba dried peel powder extract had a higher total anthocyanin and phenolic compounds content (802.90 ± 1.93 and 2152.92 ± 43.95 mg/100 g, respectively). A reduction in cell viability of HT-29 cells after treatment with M. jaboticaba extracts (DP-MJ and FD-MJ) was observed via MTT assay. Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SM had an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cells in relation to the control group. The findings of this study highlight the potential of peel powders from Myrtaceae fruits as an important source of natural antioxidants and a protective effect against colon adenocarcinoma.

scholarly journals Novel latonduine derived proligands and their copper(ii) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity

2019 ◽  
Vol 48 (28) ◽  
pp. 10464-10478 ◽  
Author(s):  
Felix Bacher ◽  
Christopher Wittmann ◽  
Márta Nové ◽  
Gabriella Spengler ◽  
Małgorzata A. Marć ◽  
...  
Keyword(s):  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Adenocarcinoma Cells ◽  
Nanomolar Range ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

The copper(ii) complexes with latonduine derivatives are superior to those with isomeric paullone modified ligands.

Cytotoxic and apoptotic effects of chalcone derivatives of 2-acetyl thiophene on human colon adenocarcinoma cells

2012 ◽  
Vol 31 (4) ◽  
pp. 289-297 ◽  
Author(s):  
Alana de Vasconcelos ◽  
Vinicius Farias Campos ◽  
Fernanda Nedel ◽  
Fabiana Kömmling Seixas ◽  
Odir A. Dellagostin ◽  
...  
Keyword(s):  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Chalcone Derivatives ◽  
Adenocarcinoma Cells ◽  
Apoptotic Effects ◽  
Derivatives Of ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

Interaction of Fibronectin with Human Colon Adenocarcinoma Cells: Effect on the in vivo Tumorigenic Capacity

Oncology ◽  
2002 ◽  
Vol 62 (4) ◽  
pp. 371-380 ◽  
Author(s):  
M. Teresa López-Conejo ◽  
Nieves Olmo ◽  
Javier Turnay ◽  
Isabel López de Silanes ◽  
M. Antonia Lizarbe
Keyword(s):  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Adenocarcinoma Cells ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

In vitro effect of lonidamine on the cytotoxicity of mitomycin C and BCNU in human colon adenocarcinoma cells

1994 ◽  
Vol 30 (10) ◽  
pp. 1534-1540 ◽  
Author(s):  
R. Villa ◽  
N. Zaffaroni ◽  
L. Orlandi ◽  
A. Bearzatto ◽  
A. Costa ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Adenocarcinoma Cells ◽  
Vitro Effect ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

In vitro models for the study of the effect of butyrate on human colon adenocarcinoma cells

2007 ◽  
Vol 21 (2) ◽  
pp. 262-270 ◽  
Author(s):  
N. Olmo ◽  
J. Turnay ◽  
P. Pérez-Ramos ◽  
E. Lecona ◽  
J.I. Barrasa ◽  
...  
Keyword(s):  
Colon Adenocarcinoma ◽  
Human Colon ◽  
In Vitro Models ◽  
Adenocarcinoma Cells ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells
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