scholarly journals The Efficiencies of Damage Recognition and Excision Correlate with Duplex Destabilization Induced by Acetylaminofluorene Adducts in Human Nucleotide Excision Repair

2012 ◽  
Vol 25 (11) ◽  
pp. 2462-2468 ◽  
Author(s):  
Jung-Eun Yeo ◽  
Andy Khoo ◽  
Adebanke F. Fagbemi ◽  
Orlando D. Schärer
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Damage Recognition ◽  
Nucleotide Excision ◽  
Duplex Destabilization

Damage recognition in nucleotide excision repair of DNA

Gene ◽  
2000 ◽  
Vol 241 (2) ◽  
pp. 193-204 ◽  
Author(s):  
Dawn P. Batty ◽  
Richard D. Wood
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Damage Recognition ◽  
Nucleotide Excision

scholarly journals Centrin 2 Stimulates Nucleotide Excision Repair by Interacting with Xeroderma Pigmentosum Group C Protein

2005 ◽  
Vol 25 (13) ◽  
pp. 5664-5674 ◽  
Author(s):  
Ryotaro Nishi ◽  
Yuki Okuda ◽  
Eriko Watanabe ◽  
Toshio Mori ◽  
Shigenori Iwai ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Xeroderma Pigmentosum ◽  
Excision Repair ◽  
Physical Interaction ◽  
C Protein ◽  
Damage Recognition ◽  
C Terminus ◽  
Nucleotide Excision ◽  
Dna Damage Recognition

ABSTRACT Xeroderma pigmentosum group C (XPC) protein plays a key role in DNA damage recognition in global genome nucleotide excision repair (NER). The protein forms in vivo a heterotrimeric complex involving one of the two human homologs of Saccharomyces cerevisiae Rad23p and centrin 2, a centrosomal protein. Because centrin 2 is dispensable for the cell-free NER reaction, its role in NER has been unclear. Binding experiments with a series of truncated XPC proteins allowed the centrin 2 binding domain to be mapped to a presumed α-helical region near the C terminus, and three amino acid substitutions in this domain abrogated interaction with centrin 2. Human cell lines stably expressing the mutant XPC protein exhibited a significant reduction in global genome NER activity. Furthermore, centrin 2 enhanced the cell-free NER dual incision and damaged DNA binding activities of XPC, which likely require physical interaction between XPC and centrin 2. These results reveal a novel vital function for centrin 2 in NER, the potentiation of damage recognition by XPC.

scholarly journals Exploring Damage Recognition Models in Prokaryotic Nucleotide Excision Repair with a Benzo[a]pyrene-Derived Lesion in UvrB

Biochemistry ◽  
2009 ◽  
Vol 48 (38) ◽  
pp. 8948-8957 ◽  
Author(s):  
Lei Jia ◽  
Konstantin Kropachev ◽  
Shuang Ding ◽  
Bennett Van Houten ◽  
Nicholas E. Geacintov ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Damage Recognition ◽  
Nucleotide Excision

scholarly journals DNA Damage Recognition of Mutated Forms of UvrB Proteins in Nucleotide Excision Repair

Biochemistry ◽  
2004 ◽  
Vol 43 (21) ◽  
pp. 6832-6832
Author(s):  
Yue Zou ◽  
Huaxian Ma ◽  
Irina G. Minko ◽  
Steven M. Shell ◽  
Zhengguan Yang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Damage Recognition ◽  
Nucleotide Excision ◽  
Dna Damage Recognition

scholarly journals Mechanism and regulation of DNA damage recognition in nucleotide excision repair

2019 ◽  
Vol 41 (1) ◽  
Author(s):  
Masayuki Kusakabe ◽  
Yuki Onishi ◽  
Haruto Tada ◽  
Fumika Kurihara ◽  
Kanako Kusao ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Damage Recognition ◽  
Nucleotide Excision ◽  
Dna Damage Recognition
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