scholarly journals Targeting of Histone Acetyltransferase p300 by Cyclopentenone Prostaglandin Δ12-PGJ2 through Covalent Binding to Cys1438

2011 ◽  
Vol 25 (2) ◽  
pp. 337-347 ◽  
Author(s):  
Kodihalli C. Ravindra ◽  
Vivek Narayan ◽  
Gerald H. Lushington ◽  
Blake R. Peterson ◽  
K. Sandeep Prabhu
Keyword(s):  
Histone Acetyltransferase ◽  
Covalent Binding ◽  
Cyclopentenone Prostaglandin ◽  
Acetyltransferase P300

scholarly journals Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yi Zhang ◽  
Kyle Brown ◽  
Yucong Yu ◽  
Ziad Ibrahim ◽  
Mohamad Zandian ◽  
...  
Keyword(s):  
Phase Separation ◽  
Cell Nucleus ◽  
Active Site ◽  
Histone Acetyltransferase ◽  
Histone H3 ◽  
Catalytic Core ◽  
Cellular Processes ◽  
Storage Pool ◽  
Core Components ◽  
Acetyltransferase P300

AbstractThe transcriptional co-activator and acetyltransferase p300 is required for fundamental cellular processes, including differentiation and growth. Here, we report that p300 forms phase separated condensates in the cell nucleus. The phase separation ability of p300 is regulated by autoacetylation and relies on its catalytic core components, including the histone acetyltransferase (HAT) domain, the autoinhibition loop, and bromodomain. p300 condensates sequester chromatin components, such as histone H3 tail and DNA, and are amplified through binding of p300 to the nucleosome. The catalytic HAT activity of p300 is decreased due to occlusion of the active site in the phase separated droplets, a large portion of which co-localizes with chromatin regions enriched in H3K27me3. Our findings suggest a model in which p300 condensates can act as a storage pool of the protein with reduced HAT activity, allowing p300 to be compartmentalized and concentrated at poised or repressed chromatin regions.

scholarly journals The histone acetyltransferase p300 promotes intrinsic axonal regeneration

Brain ◽  
2011 ◽  
Vol 134 (7) ◽  
pp. 2134-2148 ◽  
Author(s):  
Perrine Gaub ◽  
Yashashree Joshi ◽  
Anja Wuttke ◽  
Ulrike Naumann ◽  
Sven Schnichels ◽  
...  
Keyword(s):  
Axonal Regeneration ◽  
Histone Acetyltransferase ◽  
Acetyltransferase P300

scholarly journals The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

2016 ◽  
Vol 102 ◽  
pp. 130-140 ◽  
Author(s):  
Thea van den Bosch ◽  
Alexander Boichenko ◽  
Niek G.J. Leus ◽  
Maria E. Ourailidou ◽  
Hannah Wapenaar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Histone Deacetylases ◽  
Histone Acetyltransferase ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Acetyltransferase P300

Histone acetyltransferase p300 promotes the activation of human WT1 promoter and intronic enhancer

2005 ◽  
Vol 436 (1) ◽  
pp. 62-68 ◽  
Author(s):  
Yangguang Shao ◽  
Jun Lu ◽  
Guoping Zhang ◽  
Chunyan Liu ◽  
Baiqu Huang
Keyword(s):  
Histone Acetyltransferase ◽  
Intronic Enhancer ◽  
Acetyltransferase P300
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