Sustained Overexpression of CYP1A1 and 1B1 and Steady Accumulation of DNA Adducts by Low-Dose, Continuous Exposure to Benzo[a]pyrene by Polymeric Implants

2011 ◽  
Vol 24 (11) ◽  
pp. 1937-1943 ◽  
Author(s):  
Jeyaprakash Jeyabalan ◽  
Manicka V. Vadhanam ◽  
Srivani Ravoori ◽  
Ramesh C. Gupta
Keyword(s):  
Dna Adducts ◽  
Low Dose ◽  
Continuous Exposure ◽  
Polymeric Implants

Abstract 3457: Novel polymeric implants for low-dose, continuous exposure to carcinogens

2010 ◽  
Author(s):  
Jeyaprakash Jeyabalan ◽  
Pengxiao Cao ◽  
Manicka V. Vadhanam ◽  
Ramesh C. Gupta
Keyword(s):  
Low Dose ◽  
Continuous Exposure ◽  
Polymeric Implants

Continuous exposure to low-dose of bisphenol A alone or in mixture alters adiposgenesis

2012 ◽  
Vol 211 ◽  
pp. S159
Author(s):  
Sofiane Boudalia ◽  
Raymond Berges ◽  
Franck Menetrier ◽  
Cécile Helies ◽  
Marie-Chantal Canivenc-Lavier
Keyword(s):  
Bisphenol A ◽  
Low Dose ◽  
Continuous Exposure

scholarly journals Continuous Exposure to Low-Dose Cisplatin and Apoptosis

2005 ◽  
Vol 28 (10) ◽  
pp. 1954-1957 ◽  
Author(s):  
Shuichi Kishimoto ◽  
Yuji Kawazoe ◽  
Mako Ikeno ◽  
Shoji Fukushima ◽  
Yoshikazu Takeuchi
Keyword(s):  
Low Dose ◽  
Continuous Exposure

scholarly journals Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

Toxics ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 27
Author(s):  
Michael A. Malfatti ◽  
Bruce A. Buchholz ◽  
Heather A. Enright ◽  
Benjamin J. Stewart ◽  
Ted J. Ognibene ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dna Adducts ◽  
Low Dose ◽  
Lower Cost ◽  
Atomic Bomb ◽  
Age Determination ◽  
Predictive Biomarkers ◽  
Response To Chemotherapy ◽  
Recent Developments ◽  
Molecular Mass Spectrometry

This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to enable direct liquid sample analysis, coupling to HPLC for real-time AMS analysis, and combined molecular mass spectrometry and AMS for analyte identification and quantitation. Laser-based alternatives, such as cavity ring down spectrometry, are emerging to enable lower cost, higher throughput measurements of biological samples. Applications covered include radiocarbon dating, use of environmental atomic bomb pulse radiocarbon content for cell and protein age determination and turnover studies, and carbon source identification. Low dose toxicology applications reviewed include studies of naphthalene-DNA adduct formation, benzo[a]pyrene pharmacokinetics in humans, and triclocarban exposure and risk assessment. Cancer-related studies covered include the use of radiocarbon-labeled cells for better defining mechanisms of metastasis and the use of drug-DNA adducts as predictive biomarkers of response to chemotherapy.

Estimation of Mercury Body Burden from Dental Amalgam: Computer Simulation of a Metabolic Compartmental Model

1986 ◽  
Vol 65 (12) ◽  
pp. 1415-1419 ◽  
Author(s):  
M.J. Vimy ◽  
A.J. Luft ◽  
F.L. Lorscheider
Keyword(s):  
Low Dose ◽  
Body Burden ◽  
Compartment Model ◽  
Dental Amalgam ◽  
The Body ◽  
Continuous Exposure ◽  
Dental Amalgams ◽  
Wet Weight ◽  
Total Body

Estimated release rates of Hg vapor from dental amalgams permitted calculation of the potential Hg body burden by employing a four-compartment model for inorganic and elemental Hg distribution. A computer program, compatible with most personal computers, simulated the cumulative and incremental distribution in each compartment and total body accumulation between 1 and 10,000 days for different daily Hg dosages. For a given Hg dose of 30 μ g/day, metabolic compartments R1-R3 were close to equilibrium at 5, 100, and 300 days, respectively; whereas by 10,000 days, R4 closely approximated total body burden and had not yet attained equilibrium. Projected values obtained with the computer model were consistent with results obtained by another method using a standard tissue burden equation, which employed experimentally determined tissue half-lives for blood and CNS. The model predicted that continuous exposure to elemental Hg vapor, at 30 μ g/day for 10 years, would result in a total Hg body burden of 5.9 mg, of which 4.8 mg could be contained in R4. Assuming that the Hg in R4 displayed uniform distribution throughout the body, then the brain concentration was estimated to be 68 nglg wet weight. In contrast, if Hg in R4 reflected long-term preferential accumulation in brain and other neural tissue, then concentrations as high as 4.0 μ g/g could be attained. However, predictions of Hg concentrations in blood and urine were well within established ranges, and were unlikely to be of utility in assessing effects of chronic low-dose Hg exposure. It is concluded that the CNS could accumulate a substantial amount of Hg over extended time, based on low-dose elemental Hg vapor exposure via inhalation from dental amalgams.

Lymphocytes,DNA adducts and genetic polymorphism for metabolic enzymes in low dose cigarette smokers

Biomarkers ◽  
1998 ◽  
Vol 3 (1) ◽  
pp. 63-71 ◽  
Author(s):  
MASAYOSHI ICHIBA ◽  
YANPING WANG ◽  
HIROTAKA OISHI ◽  
JIUSONG ZHANG ◽  
MINAKO IYADOMI ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Dna Adducts ◽  
Low Dose ◽  
Metabolic Enzymes ◽  
Cigarette Smokers
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