The Hepatocyte Suspension Assay Is Superior to the Cultured Hepatocyte Assay for Determining Mechanisms of Acetaminophen Hepatotoxicity Relevant toin VivoToxicity

2010 ◽  
Vol 23 (12) ◽  
pp. 1855-1858 ◽  
Author(s):  
Angela S. Burke ◽  
Lee Ann MacMillan-Crow ◽  
Jack A. Hinson
Keyword(s):  
Cultured Hepatocyte ◽  
Acetaminophen Hepatotoxicity ◽  
Hepatocyte Suspension

Acetaminophen Hepatotoxicity

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 1021-1021 ◽  
Author(s):  
Timothy J. Davern
Keyword(s):  
Acetaminophen Hepatotoxicity

Human keratin 8 variants predispose to acetaminophen hepatotoxicity

2014 ◽  
Vol 52 (01) ◽  
Author(s):  
N Guldiken ◽  
Q Zhou ◽  
O Kucukoglu ◽  
M Rehm ◽  
LP James ◽  
...  
Keyword(s):  
Keratin 8 ◽  
Acetaminophen Hepatotoxicity

scholarly journals Cimetidine Protects Against Acetaminophen Hepatotoxicity in Rats

1981 ◽  
Vol 81 (6) ◽  
pp. 1052-1060 ◽  
Author(s):  
Mack C. Mitchell ◽  
Steven Schenker ◽  
G.R. Avant ◽  
K.V. Speeg
Keyword(s):  
Acetaminophen Hepatotoxicity

scholarly journals Multicenter Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses

2007 ◽  
Vol 99 (1) ◽  
pp. 326-337 ◽  
Author(s):  
Richard P. Beyer ◽  
Rebecca C. Fry ◽  
Michael R. Lasarev ◽  
Lisa A. McConnachie ◽  
Lisiane B. Meira ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Genomic Analyses ◽  
Acetaminophen Hepatotoxicity

Conformational change in plasma albumin due to interaction with isolated rat hepatocyte

1988 ◽  
Vol 254 (4) ◽  
pp. G465-G470 ◽  
Author(s):  
T. Horie ◽  
T. Mizuma ◽  
S. Kasai ◽  
S. Awazu
Keyword(s):  
Conformational Change ◽  
Organic Anion ◽  
Resonance Spectroscopy ◽  
Hepatic Transport ◽  
Rat Hepatocyte ◽  
Plasma Albumin ◽  
Spin Resonance ◽  
Albumin Molecule ◽  
Hepatocyte Suspension ◽  
Isolated Rat

The electron spin resonance spectroscopy of 4-isothiocyanato-tempo labeled to bovine serum albumin (BSA) and the absorption spectroscopy of eosin maleimide labeled to BSA in the isolated rat hepatocyte suspension indicate conformational change occurring in the albumin molecule during interaction with the hepatocellular membrane. The conformational change in the albumin molecule may possibly accelerate the dissociation of albumin-organic anion complexes at the surface of the liver cell. The conformational change in the albumin molecule may explain in part the mechanism of albumin-mediated hepatic transport.

scholarly journals Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

2018 ◽  
Vol 93 (1) ◽  
pp. 163-178 ◽  
Author(s):  
Kuo Du ◽  
Anup Ramachandran ◽  
James L. Weemhoff ◽  
Benjamin L. Woolbright ◽  
Andrew H. Jaeschke ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Late Phase ◽  
Acetaminophen Hepatotoxicity
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