Stereoselective Metabolic Activation of α-Hydroxy-N-desmethyltamoxifen:  TheR-Isomer Forms More DNA Adducts in Rat Liver Cells

2004 ◽  
Vol 17 (5) ◽  
pp. 697-701 ◽  
Author(s):  
Martin R. Osborne ◽  
Alan Hewer ◽  
David H. Phillips
Keyword(s):  
Rat Liver ◽  
Dna Adducts ◽  
Metabolic Activation ◽  
Liver Cells ◽  
Rat Liver Cells

Metabolic Activation of Procarcinogens to Genotoxic Products in Cultured Rat Liver Cells

Pathobiology ◽  
1984 ◽  
Vol 52 (6) ◽  
pp. 355-360
Author(s):  
G L. Murison ◽  
S D. Hall ◽  
A M. Lee
Keyword(s):  
Rat Liver ◽  
Metabolic Activation ◽  
Liver Cells ◽  
Rat Liver Cells

Metabolic activation of 2-acetylaminofluorene by isolated rat liver cells

1980 ◽  
Vol 45 (1) ◽  
pp. 53-59 ◽  
Author(s):  
R. M. E. Brouns ◽  
R. P. Bos ◽  
R. v. Doom ◽  
P. Th. Henderson
Keyword(s):  
Rat Liver ◽  
Metabolic Activation ◽  
Liver Cells ◽  
Isolated Rat Liver ◽  
Rat Liver Cells ◽  
Isolated Rat

Resolution of α-Hydroxytamoxifen; R-Isomer Forms More DNA Adducts in Rat Liver Cells

2001 ◽  
Vol 14 (7) ◽  
pp. 888-893 ◽  
Author(s):  
Martin R. Osborne ◽  
Alan Hewer ◽  
David H. Phillips
Keyword(s):  
Rat Liver ◽  
Dna Adducts ◽  
Liver Cells ◽  
Rat Liver Cells

scholarly journals N-Demethylation accompanies α-hydroxylation in the metabolic activation of tamoxifen in rat liver cells

1999 ◽  
Vol 20 (10) ◽  
pp. 2003-2009 ◽  
Author(s):  
David H. Phillips ◽  
Alan Hewer ◽  
Martin N. Horton ◽  
Kathleen J. Cole ◽  
Paul L. Carmichael ◽  
...  
Keyword(s):  
Rat Liver ◽  
Metabolic Activation ◽  
Liver Cells ◽  
Rat Liver Cells

Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells

1994 ◽  
Vol 15 (11) ◽  
pp. 2541-2546 ◽  
Author(s):  
Dieter Schrenk ◽  
Timothy W. Gant ◽  
Alfred Michalke ◽  
Achim Orzechowski ◽  
Jeffrey A. Silverman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Rat Liver ◽  
Metabolic Activation ◽  
Liver Cells ◽  
Multidrug Resistance Gene ◽  
Rat Liver Cells

4-Hydroxytamoxifen Gives DNA Adducts by Chemical Activation, but Not in Rat Liver Cells

1999 ◽  
Vol 12 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Martin R. Osborne ◽  
Warren Davis ◽  
Alan J. Hewer ◽  
Ian R. Hardcastle ◽  
David H. Phillips
Keyword(s):  
Rat Liver ◽  
Dna Adducts ◽  
Chemical Activation ◽  
Liver Cells ◽  
Rat Liver Cells

Effects of Hypophysectomy on the Fine Structure of Rat Liver Cells

1967 ◽  
Vol 25 ◽  
pp. 156-157
Author(s):  
Robert R. Cardell
Keyword(s):  
Electron Microscopy ◽  
Fine Structure ◽  
Rat Liver ◽  
Liver Cell ◽  
Anterior Pituitary ◽  
Liver Cells ◽  
Biochemical Studies ◽  
Liver Functions ◽  
Rat Liver Cells ◽  
And Control

Hypophysectomy of the rat renders this animal deficient in the hormones of the anterior pituitary gland, thus causing many primary and secondary hormonal effects on basic liver functions. Biochemical studies of these alterations in the rat liver cell are quite extensive; however, relatively few morphological observations on such cells have been recorded. Because the available biochemical information was derived mostly from disrupted and fractionated liver cells, it seemed desirable to examine the problem with the techniques of electron microscopy in order to see what changes are apparent in the intact liver cell after hypophysectomy. Accordingly, liver cells from rats which had been hypophysectomized 5-120 days before sacrifice were studied. Sham-operated rats served as controls and both hypophysectomized and control rats were fasted 15 hours before sacrifice.

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