scholarly journals Human Liver Microsomal Metabolism and DNA Adduct Formation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine Volume 16, Number 1, January 2003, pp 66−73

2003 ◽  
Vol 16 (3) ◽  
pp. 432-432
Author(s):  
Qingsu Xia ◽  
Ming W. Chou ◽  
Fred F. Kadlubar ◽  
Po-Cheun Chan ◽  
Peter P. Fu
Keyword(s):  
Human Liver ◽  
Pyrrolizidine Alkaloid ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Microsomal Metabolism

Human Liver Microsomal Metabolism and DNA Adduct Formation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine

2003 ◽  
Vol 16 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Qingsu Xia ◽  
Ming W. Chou ◽  
Fred. F. Kadlubar ◽  
Po-Cheun Chan ◽  
Peter P. Fu
Keyword(s):  
Human Liver ◽  
Pyrrolizidine Alkaloid ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Microsomal Metabolism

Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo

2005 ◽  
Vol 226 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Yu-Ping Wang ◽  
Jian Yan ◽  
Richard D. Beger ◽  
Peter P. Fu ◽  
Ming W. Chou
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Metabolic Activation ◽  
Adduct Formation ◽  
Dna Adduct

scholarly journals A modeling approach to evaluate the balance between bioactivation and detoxification of MeIQx in human hepatocytes

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3703 ◽  
Author(s):  
Victorien Delannée ◽  
Sophie Langouët ◽  
Nathalie Théret ◽  
Anne Siegel
Keyword(s):  
Human Liver ◽  
Genome Instability ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Heterocyclic Aromatic Amines ◽  
Food Contaminants ◽  
Formation Pathway ◽  
Key Enzyme ◽  
Genotoxic Compounds ◽  
Organ Models

Background Heterocyclic aromatic amines (HAA) are environmental and food contaminants that are potentially carcinogenic for humans. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is one of the most abundant HAA formed in cooked meat. MeIQx is metabolized by cytochrome P450 1A2 in the human liver into detoxificated and bioactivated products. Once bioactivated, MeIQx metabolites can lead to DNA adduct formation responsible for further genome instability. Methods Using a computational approach, we developed a numerical model for MeIQx metabolism in the liver that predicts the MeIQx biotransformation into detoxification or bioactivation pathways according to the concentration of MeIQx. Results Our results demonstrate that (1) the detoxification pathway predominates, (2) the ratio between detoxification and bioactivation pathways is not linear and shows a maximum at 10 µM of MeIQx in hepatocyte cell models, and (3) CYP1A2 is a key enzyme in the system that regulates the balance between bioactivation and detoxification. Our analysis suggests that such a ratio could be considered as an indicator of MeIQx genotoxicity at a low concentration of MeIQx. Conclusions Our model permits the investigation of the balance between bioactivation (i.e., DNA adduct formation pathway through the prediction of potential genotoxic compounds) and detoxification of MeIQx in order to predict the behaviour of this environmental contaminant in the human liver. It highlights the importance of complex regulations of enzyme competitions that should be taken into account in any further multi-organ models.

DNA Adduct Formation of Selected Sex Steroids in Human Liver Slices In Vitro

1998 ◽  
Vol 12 (4) ◽  
pp. 353-364 ◽  
Author(s):  
W. Feser ◽  
R.S. Kerdar ◽  
A. Baumann ◽  
J. Körber ◽  
H. Blode ◽  
...  
Keyword(s):  
Sex Steroids ◽  
Human Liver ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Liver Slices ◽  
Human Liver Slices

Metabolic Activation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine, Leading to DNA Adduct Formation in Vivo

2001 ◽  
Vol 14 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Ya-Chen Yang ◽  
Jian Yan ◽  
Daniel R. Doerge ◽  
Po-Cheun Chan ◽  
Peter P. Fu ◽  
...  
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Metabolic Activation ◽  
Adduct Formation ◽  
Dna Adduct
Sign in / Sign up

Export Citation Format

Share Document