Site-Specific Hydroxylation at Polyguanosine in Double-Stranded DNA by Nickel(II) in the Presence of SH Compounds:  Comparison with Singlet Oxygen-Induced DNA Damage

2002 ◽  
Vol 15 (8) ◽  
pp. 1017-1022 ◽  
Author(s):  
Shinji Oikawa ◽  
Yusuke Hiraku ◽  
Tatsuhiko Fujiwara ◽  
Isao Saito ◽  
Shosuke Kawanishi
Keyword(s):  
Dna Damage ◽  
Singlet Oxygen ◽  
Site Specific ◽  
Double Stranded Dna

Site-specific DNA damage induced by cobalt(II) ion and hydrogen peroxide: role of singlet oxygen

1989 ◽  
Vol 2 (4) ◽  
pp. 234-239 ◽  
Author(s):  
Koji Yamamoto ◽  
Sumiko Inoue ◽  
Atsuko Yamazaki ◽  
Takeo Yoshinaga ◽  
Shosuke Kawanishi
Keyword(s):  
Hydrogen Peroxide ◽  
Dna Damage ◽  
Singlet Oxygen ◽  
Site Specific

Singlet oxygen mediated DNA damage induced phototoxicity by ketoprofen resulting in mitochondrial depolarization and lysosomal destabilization

Toxicology ◽  
2013 ◽  
Vol 314 (2-3) ◽  
pp. 229-237 ◽  
Author(s):  
Ratan Singh Ray ◽  
Syed Faiz Mujtaba ◽  
Ashish Dwivedi ◽  
Neera Yadav ◽  
Ankit Verma ◽  
...  
Keyword(s):  
Dna Damage ◽  
Singlet Oxygen ◽  
Mitochondrial Depolarization

scholarly journals DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Prasun Chakraborty ◽  
Kevin Hiom
Keyword(s):  
Dna Damage ◽  
Homologous Recombination ◽  
Rna Polymerase Ii ◽  
Critical Role ◽  
Dna Breaks ◽  
Double Stranded Dna ◽  
Recombination Repair ◽  
Dna End Resection ◽  
End Resection ◽  
Rna Polymerase Ii Transcription

AbstractDouble stranded DNA Breaks (DSB) that occur in highly transcribed regions of the genome are preferentially repaired by homologous recombination repair (HR). However, the mechanisms that link transcription with HR are unknown. Here we identify a critical role for DHX9, a RNA helicase involved in the processing of pre-mRNA during transcription, in the initiation of HR. Cells that are deficient in DHX9 are impaired in the recruitment of RPA and RAD51 to sites of DNA damage and fail to repair DSB by HR. Consequently, these cells are hypersensitive to treatment with agents such as camptothecin and Olaparib that block transcription and generate DSB that specifically require HR for their repair. We show that DHX9 plays a critical role in HR by promoting the recruitment of BRCA1 to RNA as part of the RNA Polymerase II transcription complex, where it facilitates the resection of DSB. Moreover, defects in DHX9 also lead to impaired ATR-mediated damage signalling and an inability to restart DNA replication at camptothecin-induced DSB. Together, our data reveal a previously unknown role for DHX9 in the DNA Damage Response that provides a critical link between RNA, RNA Pol II and the repair of DNA damage by homologous recombination.

scholarly journals Involvement of Escherichia coli exonuclease III and endonuclease IV in the repair of singlet oxygen-induced DNA damage

1996 ◽  
Vol 17 (5) ◽  
pp. 1183-1185 ◽  
Author(s):  
Lucymara F. Agnez ◽  
Regina L.Costa de Oliveira ◽  
Paolo Di Mascio ◽  
Carlos F.M. Menck
Keyword(s):  
Escherichia Coli ◽  
Dna Damage ◽  
Singlet Oxygen ◽  
Exonuclease Iii

Mechanism of site-specific DNA damage induced by methylhydrazines in the presence of copper(II) or manganese(III)

Biochemistry ◽  
1991 ◽  
Vol 30 (12) ◽  
pp. 3069-3075 ◽  
Author(s):  
Shosuke Kawanishi ◽  
Koji Yamamoto
Keyword(s):  
Dna Damage ◽  
Site Specific
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