Investigations of Glutathione Conjugation in Vitro by 1H NMR Spectroscopy. Uncatalyzed and Glutathione Transferase-Catalyzed Reactions

1995 ◽  
Vol 8 (5) ◽  
pp. 780-791 ◽  
Author(s):  
Gina Kubal ◽  
David J. Meyer ◽  
Richard E. Norman ◽  
Peter J. Sadler
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Glutathione Transferase ◽  
Glutathione Conjugation ◽  
Catalyzed Reactions

Choline-Containing Compounds in Human Astrocytomas Studied by 1H NMR Spectroscopy In Vivo and In Vitro

2002 ◽  
Vol 63 (4) ◽  
pp. 1538-1543 ◽  
Author(s):  
Jussi-Pekka Usenius ◽  
Pauli Vainio ◽  
Juha Hernesniemi ◽  
Risto A. Kauppinen
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Human Astrocytomas

scholarly journals Defect in Dimethylglycine Dehydrogenase, a New Inborn Error of Metabolism: NMR Spectroscopy Study

1999 ◽  
Vol 45 (4) ◽  
pp. 459-464 ◽  
Author(s):  
Sytske H Moolenaar ◽  
Jo Poggi-Bach ◽  
Udo FH Engelke ◽  
Jacqueline MB Corstiaensen ◽  
Arend Heerschap ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
Inborn Error ◽  
1H Nmr Spectroscopy ◽  
13C Nmr Spectroscopy ◽  
Inborn Error Of Metabolism ◽  
Gas Chromatography Mass Spectrometry ◽  
High Concentration ◽  
History Of

Abstract Background: A38-year-old man presented with a history of fish odor (since age 5) and unusual muscle fatigue with increased serum creatine kinase. Our aim was to identify the metabolic error in this new condition. Methods: We used 1H NMR spectroscopy to study serum and urine from the patient. Results: The concentration of N,N-dimethylglycine (DMG) was increased ∼100-fold in the serum and ∼20-fold in the urine. The presence of DMG as a storage product was confirmed by use of 13C NMR spectroscopy and gas chromatography–mass spectrometry. The high concentration of DMG was caused by a deficiency of the enzyme dimethylglycine dehydrogenase (DMGDH). A homozygous missense mutation was found in the DMGDH gene of the patient. Conclusions: DMGDH deficiency must be added to the differential diagnosis of patients complaining of a fish odor. This deficiency is the first inborn error of metabolism discovered by use of in vitro 1H NMR spectroscopy of body fluids.

scholarly journals Novel chloroquine loaded curcumin based anionic linear globular dendrimer G2: a metabolomics study on Plasmodium falciparum in vitro using 1H NMR spectroscopy – CORRIGENDUM

Parasitology ◽  
2020 ◽  
Vol 147 (9) ◽  
pp. 1064-1064
Author(s):  
Taher Elmi ◽  
Mehdi Shafiee Ardestani ◽  
Fateme Hajialiani ◽  
Manijeh Motevalian ◽  
Maryam Mohamadi ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Metabolomics Study

Application of the reverse dept polarization-transfer pulse sequence to monitor in vitro and in vivo metabolism of 13C-ethanol by 1H-NMR spectroscopy

1985 ◽  
Vol 17 (4) ◽  
pp. 471-478 ◽  
Author(s):  
Michael G. Irving ◽  
Stephen J. Simpson ◽  
William M. Brooks ◽  
Roger S. Holmes ◽  
David M. Doddrell
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Pulse Sequence ◽  
Polarization Transfer ◽  
In Vivo Metabolism
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