DNA Topoisomerase II Inhibition by Peroxisomicine A1and Its Radical Metabolite Induces Apoptotic Cell Death of HL-60 and HL-60/MX2 Human Leukemia Cells

2001 ◽  
Vol 14 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Amélie Lansiaux ◽  
William Laine ◽  
Brigitte Baldeyrou ◽  
Christine Mahieu ◽  
Nicole Wattez ◽  
...  
Keyword(s):  
Cell Death ◽  
Topoisomerase Ii ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Leukemia Cells

Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells

2016 ◽  
Vol 61 (3) ◽  
pp. 381-395 ◽  
Author(s):  
Carlos Quintana ◽  
Javier Cabrera ◽  
Juan Perdomo ◽  
Francisco Estévez ◽  
Juan F. Loro ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells

scholarly journals UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

2011 ◽  
Vol 81 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Tom Juncker ◽  
Claudia Cerella ◽  
Marie-Hélène Teiten ◽  
Franck Morceau ◽  
Marc Schumacher ◽  
...  
Keyword(s):  
Cell Death ◽  
Cardiac Glycoside ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells

scholarly journals 4-Hydroxyderricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia Cells

2011 ◽  
Vol 60 (2) ◽  
pp. 71-77 ◽  
Author(s):  
Toshihiro Akihisa ◽  
Takashi Kikuchi ◽  
Hisashi Nagai ◽  
Koichi Ishii ◽  
Keiichi Tabata ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells ◽  
Angelica Keiskei

Induction of apoptotic cell death by DNA topoisomerase II inhibitors

Biochimie ◽  
1995 ◽  
Vol 77 (11) ◽  
pp. 893-899 ◽  
Author(s):  
C. Negri ◽  
R. Bernardi ◽  
M. Donzelli ◽  
A.I. Scovassi
Keyword(s):  
Cell Death ◽  
Topoisomerase Ii ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Topoisomerase Ii Inhibitors

Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II

2010 ◽  
Vol 30 (1) ◽  
pp. 212-222 ◽  
Author(s):  
Xia Xue ◽  
Xian-Jun Qu ◽  
Zu-Hua Gao ◽  
Cui-Cui Sun ◽  
Hui-Ping Liu ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Leukemia Cells

Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure–Activity Relationships

2017 ◽  
Vol 45 (07) ◽  
pp. 1497-1511 ◽  
Author(s):  
Shinya Okubo ◽  
Takuhiro Uto ◽  
Aya Goto ◽  
Hiroyuki Tanaka ◽  
Tsuyoshi Nishioku ◽  
...  
Keyword(s):  
Cell Death ◽  
Dna Fragmentation ◽  
Antiproliferative Activity ◽  
Caspase 3 ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Leukemia Cells ◽  
Caspase 8 ◽  
Human Leukemia ◽  
Caspase 9

Berberine (BBR), an isoquinoline alkaloid, is a well-known bioactive compound contained in medicinal plants used in traditional and folk medicines. In this study, we investigated the subcellular localization and the apoptotic mechanisms of BBR were elucidated. First, we confirmed the incorporation of BBR into the cell visually. BBR showed antiproliferative activity and promptly localized to the nucleus from 5[Formula: see text]min to 15[Formula: see text]min after BBR treatment in HL-60 human promyelocytic leukemia cells. Next, we examined the antiproliferative activity of BBR (1) and its biosynthetically related compounds (2-7) in HL-60 cells. BBR exerted strongest antiproliferative activity among 1-7 and the results of structures and activity relation suggested that a methylenedioxyl group in ring A, an [Formula: see text]-alkyl group at C-9 position, and the frame of isoquinoline may be necessary for antiproliferative activity. Moreover, BBR showed the most potent antiproliferative activity in HL-60 cells among human cancer and normal cell lines tested. Next, we examined the effect of BBR on molecular events known as apoptosis induction. In HL-60 cells, BBR induced chromatin condensation and DNA fragmentation, and triggered the activation of PARP, caspase-3 and caspase-8 without the activation of caspase-9. BBR-induced DNA fragmentation was abolished by pretreatment with inhibitors against caspase-3 and caspase-8, but not against caspase-9. ERK and p38 were promptly phosphorylated after 15 min of BBR treatment, and this was correlated with time of localization to the nucleus of BBR. These results demonstrated that BBR translocated into nucleus immediately after treatments and induced apoptotic cell death by activation of caspase-3 and caspase-8.

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