Inhibition of hepatic drug metabolism by phenothiazine tranquilizers: quantitative structure-activity relationships and selective inhibition of cytochrome P-450 isoform-specific activities

Michael Murray

doi:10.1021/tx00010a005

Inhibition of hepatic drug metabolism by phenothiazine tranquilizers: quantitative structure-activity relationships and selective inhibition of cytochrome P-450 isoform-specific activities

Chemical Research in Toxicology ◽

10.1021/tx00010a005 ◽

1989 ◽

Vol 2 (4) ◽

pp. 240-246 ◽

Cited By ~ 6

Author(s):

Michael Murray

Keyword(s):

Drug Metabolism ◽

Selective Inhibition ◽

Hepatic Drug Metabolism ◽

Quantitative Structure ◽

Hepatic Drug ◽

Structure Activity Relationships ◽

Structure Activity ◽

Specific Activities ◽

Quantitative Structure Activity Relationships ◽

Cytochrome P 450

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Structure-activity relationships in the induction of hepatic drug metabolism by azo compounds

Xenobiotica ◽

10.3109/00498258409151449 ◽

1984 ◽

Vol 14 (7) ◽

pp. 565-568 ◽

Cited By ~ 6

Author(s):

S. Fujita ◽

M. Suzuki ◽

T. Suzuki

Keyword(s):

Drug Metabolism ◽

Azo Compounds ◽

Hepatic Drug Metabolism ◽

Hepatic Drug ◽

Structure Activity Relationships ◽

Structure Activity

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Quantitative structure-activity relationships in a series of alcohols exhibiting inhibition of cytochrome P-450-mediated aniline hydroxylation

Chemico-Biological Interactions ◽

10.1016/0009-2797(87)90027-5 ◽

1987 ◽

Vol 62 (3) ◽

pp. 271-280 ◽

Cited By ~ 17

Author(s):

David F.V. Lewis

Keyword(s):

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Cytochrome P 450

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Quantitative structure—Activity relationships in a series of urea derivatives—Liver cytochrome P-450 inductors analyzed by the modified method of frontal polyhedra

Pharmaceutical Chemistry Journal ◽

10.1007/bf02464126 ◽

1997 ◽

Vol 31 (6) ◽

pp. 320-325

Author(s):

A. I. Khlebnikov ◽

A. A. Bakibaev ◽

R. R. Akhmedzhanov ◽

T. P. Novozheeva ◽

A. S. Saratikov

Keyword(s):

Quantitative Structure ◽

Urea Derivatives ◽

Structure Activity Relationships ◽

Liver Cytochrome ◽

Modified Method ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Cytochrome P 450

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Quantitative structure–activity relationships in drug metabolism and disposition: Pharmacokinetics of N-substituted amphetamines in humans

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600690505 ◽

1980 ◽

Vol 69 (5) ◽

pp. 497-501 ◽

Cited By ~ 13

Author(s):

Bernard Testa ◽

Bjarne Salvesen

Keyword(s):

Drug Metabolism ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Substituted Amphetamines ◽

Quantitative Structure Activity Relationships

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Quantitative Structure-Activity Relationships (QSARs) Within Substrates of Human Cytochromes P450 Involved in Drug Metabolism

Drug Metabolism and Drug Interactions ◽

10.1515/dmdi.2001.18.3-4.221 ◽

2001 ◽

Vol 18 (3-4) ◽

Cited By ~ 18

Author(s):

D.F.V. Lewis ◽

S. Modi ◽

M. Dickins

Keyword(s):

Drug Metabolism ◽

Cytochromes P450 ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative Structure Activity Relationships in Drug Metabolism

Current Topics in Medicinal Chemistry ◽

10.2174/156802606778108960 ◽

2006 ◽

Vol 6 (15) ◽

pp. 1569-1578 ◽

Cited By ~ 29

Author(s):

Kamaldeep Chohan ◽

Stuart Paine ◽

Nigel Waters

Keyword(s):

Drug Metabolism ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative Structure-Activity Relationships of Cytochrome P-450

Drug Metabolism Reviews ◽

10.3109/03602539308993972 ◽

1993 ◽

Vol 25 (1-2) ◽

pp. 1-48 ◽

Cited By ~ 52

Author(s):

Corwin Hansch ◽

Litai Zhang

Keyword(s):

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Cytochrome P 450

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Quantitative Structure-Activity Relationships in the Displacement of the Dihydrosafrole Metabolite-Cytochrome P-450 Complex

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.19850040105 ◽

1985 ◽

Vol 4 (1) ◽

pp. 18-22 ◽

Cited By ~ 3

Author(s):

Michael Murray ◽

Craig B. Marcus ◽

Christopher F. Wilkinson

Keyword(s):

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Cytochrome P 450

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Quantitative Structure-Activity Relationships of Potential Antimalarial Drugs Active Against Chloroquine-Resistant Plasmodium Falciparum

Planta Medica ◽

10.1055/s-2008-1075144 ◽

2008 ◽

Vol 74 (03) ◽

Author(s):

SJ Hocart ◽

H Liu ◽

D De ◽

FM Krogstad ◽

DJ Krogstad

Keyword(s):

Plasmodium Falciparum ◽

Antimalarial Drugs ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Parabolic Quantitative Structure–Activity Relationships and Photodynamic Therapy: Application of a Three-Compartment Model with Clearance to the In Vivo Quantitative Structure–Activity Relationships of a Congeneric Series of Pyropheophorbide Derivatives Used as Photosensitizers for Photodynamic Therapy

Photochemistry and Photobiology ◽

10.1562/0031-8655(1999)070<0781:pqsrap>2.3.co;2 ◽

1999 ◽

Vol 70 (5) ◽

pp. 781 ◽

Cited By ~ 2

Author(s):

W. R. Potter ◽

B. W. Henderson ◽

D. A. Bellnier ◽

R. K. Pandey ◽

L. A. Vaughan ◽

...

Keyword(s):

Photodynamic Therapy ◽

Compartment Model ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Three Compartment Model ◽

Quantitative Structure Activity Relationships

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