scholarly journals Metabolic excretion profile of clinical asthma compound MIDD0301

2021 ◽  
Author(s):  
Md Shadiqur Rashid Roni ◽  
Nick Zahn ◽  
Brandon Mikulsky ◽  
Md Yeunus Mian ◽  
Daniel Webb ◽  
...  
Keyword(s):  
Clinical Asthma

Airborne particulates and asthma: a Maine case study

2005 ◽  
Vol 21 (1-2) ◽  
pp. 75-92 ◽  
Author(s):  
Samantha J Langley-Turnbaugh ◽  
Nancy R Gordon ◽  
Thomas Lambert
Keyword(s):  
Rural Areas ◽  
Culture Medium ◽  
Adult Population ◽  
Temporal Trends ◽  
Soil Samples ◽  
Acid Extraction ◽  
Crustal Material ◽  
Cell Culture Medium ◽  
Clinical Asthma

Maine currently has the second fastest growing asthma rate in the nation- 9.4% of the adult population has asthma and one out of eight children is affected. The factors behind this increase are poorly understood, but previous reports suggest that biologically soluble metal ions from particulate matter (PM10) may play a role in asthma episodes. In an effort to study this issue, we first identified geographic and temporal trends in Maine asthma hospitalizations. Clinical data show a strong fall peak in asthma admissions with weaker peaks in January and May, and a summer low in asthma admissions. Asthma admissions are also higher in the cities than in the rural areas in Maine. We then analysed PM10 collected by the Maine Department of Environmental Protection in three different Maine locations in the years 2000 and 2001, at times when clinical asthma data showed peaks and during the summer low period. We also collected soil samples in the same locations. The PM10 and soils were analysed for 10 metals by acid extraction to determine total metal content and then with cell culture medium, DMEM/F12+CCS growth medium, to determine metal biosolubility. Our results showed that Mn, Cu, Pb, As, V, Ni and Al were present in the Maine PM samples. V, Ni and Pb showed seasonal variation, while the others were relatively constant throughout the year. Pb and Al did not appear to be soluble in the biological medium. There was also variation from location to location with the urban area showing the highest concentrations for most metals. Aluminium was present in the highest concentration in soil samples, followed by Mn and V. Only Cu was biologically available in soils. We determined from M/Al ratios that most of the PM10 did not originate from local crustal material.

Asthma Control Test™ in Assessment of Clinical Asthma Control

2009 ◽  
Vol 2 (4) ◽  
pp. 341-346
Author(s):  
Jordan Minov ◽  
Jovanka Bislimovska-Karadzhinska ◽  
Tatjana Petrova ◽  
Kristin Vasilevska ◽  
Snezana Risteska-Kuc ◽  
...  
Keyword(s):  
Asthma Control ◽  
Control Test ◽  
Asthma Control Test ◽  
Clinical Asthma

scholarly journals Improved Scale-up Synthesis and Purification of Clinical Asthma Candidate MIDD0301

2020 ◽  
Vol 24 (8) ◽  
pp. 1467-1476
Author(s):  
Daniel E. Knutson ◽  
M. S. Rashid Roni ◽  
Md Yeunus Mian ◽  
James M. Cook ◽  
Douglas C. Stafford ◽  
...  
Keyword(s):  
Scale Up ◽  
Clinical Asthma

scholarly journals Cluster Analysis and Clinical Asthma Phenotypes

2008 ◽  
Vol 178 (3) ◽  
pp. 218-224 ◽  
Author(s):  
Pranab Haldar ◽  
Ian D. Pavord ◽  
Dominic E. Shaw ◽  
Michael A. Berry ◽  
Michael Thomas ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Asthma Phenotypes ◽  
Clinical Asthma
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