scholarly journals When 2 is better than 1: Recent advances in the seniority scheme

2020 ◽  
Author(s):  
Stijn De Baerdemacker
Keyword(s):  
Recent Advances ◽  
Better Than

Recent Advances in Predicting ncRNA-Protein Interactions Based on Machine Learning

2021 ◽  
Vol 01 ◽  
Author(s):  
Jingjing Wang ◽  
Yanpeng Zhao ◽  
Xiaoqian Huang ◽  
Yi Shi ◽  
Jianjun Tan
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Protein Interactions ◽  
Predictive Performance ◽  
Research Approach ◽  
Learning Models ◽  
Recent Advances ◽  
Conventional Machine ◽  
Near Future ◽  
Better Than

: Non-coding RNAs (ncRNAs) play significant roles in various physiological and pathological processes via interacting with the proteins. The existing experimental methods used for predicting ncRNA-protein interactions are costly and time-consuming. Therefore, an increasing number of machine learning models have been developed to efficiently predict ncRNA-protein interactions (ncRPIs), including shallow machine learning and deep learning models, which have achieved dramatic achievement on the identification of ncRPIs. In this review, we provided an overview of the recent advances in various machine learning methods for predicting ncRPIs, mainly focusing on ncRNAs-protein interaction databases, classical datasets, ncRNA/protein sequence encoding methods, conventional machine learning-based models, deep learning-based models, and the two integration-based models. Furthermore, we compared the reported accuracy of these approaches and discussed the potential and limitations of deep learning applications in ncRPIs. It was found that the predictive performance of integrated deep learning is the best, and those deep learning-based methods do not always perform better than shallow machine learning-based methods. We discussed the potential of using deep learning and proposed a research approach on the basis of the existing research. We believe that the model based on integrated deep learning is able to achieve higher accuracy in the prediction if substantial experimental data were available in the near future.

scholarly journals Bakerian lecture.—“Recent advances in seismology.”

1906 ◽  
Vol 77 (518) ◽  
pp. 365-376 ◽  
Keyword(s):  
Royal Society ◽  
Systematic Investigation ◽  
Present Form ◽  
General Knowledge ◽  
Material Development ◽  
Recent Advances ◽  
Classical Work ◽  
Distinct Branch ◽  
Observational Science ◽  
Better Than

All who are interested in the progress of science recoguise that at the present time Seismology receives an attention vastly different from that accorded to it only a few years ago. The old Seismology consisted of but little more than scattered accounts of great convulsions which altered the appearance of vast tracts of country and which were frequently accompanied by appalling destruction. For the most part these accounts were little better than the narratives which, in early times, exciting the imagination of primitive communities, gave rise to myths which have left their mark in literature, art, and religion. Not until the interval between the years 1840 and 1860 by the strenuous labours of many workers, amongst whom Perry and Mallet were conspicuous, was a general knowledge of the distribution of earthquakes in space and time reached. Mallet, in his classical work on the Neapolitan earthquake of 1859, drawn up under the auspices of the Royal Society, showed that from the ruins of a town many facts of scientific importance could be gathered. This work together with that of a few other seismologists, gave the first indications that earthquake phenomena lent themselves to systematic investigation. But little further progress was made until 1880, when as a side issue of Japan’s material development along western lines, Seismology began to grow with great rapidity into its present form and became a distinct branch of observational science.

scholarly journals A Greedy Algorithm for Over-The-Cell Channel Routing

VLSI Design ◽  
1996 ◽  
Vol 5 (1) ◽  
pp. 23-36
Author(s):  
Gudni Gudmundsson ◽  
Simeon Ntafos
Keyword(s):  
Greedy Algorithm ◽  
Final Stage ◽  
Maximum Density ◽  
Greedy Heuristics ◽  
Channel Routing ◽  
Channel Density ◽  
Recent Advances ◽  
Vlsi Technology ◽  
Better Than

Recent advances in VLSI technology have made the area over cells available for routing. In this paper we present a new over-the-cell channel router that uses greedy heuristics to make the over-the-cell connections and to define the nets needed to complete the connections inside the channel. The router tries to reduce the channel density by moving segments that cross maximum density columns to the over-the-cell areas. The layout model used allows only planar connections over each cell. The final stage is to use an existing channel router to route the connections inside the channel. An important characteristic of the new router is that there is interaction between the decisions made for the over-the-cell connections and the connections needed inside the channel. It performs significantly better than previous over the-cell routers.

Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

1988 ◽  
Vol 132 ◽  
pp. 525-530
Author(s):  
Raffaele G. Gratton
Keyword(s):  
Globular Cluster ◽  
Globular Clusters ◽  
High Dispersion ◽  
Photographic Material ◽  
Recent Advances ◽  
Metal Abundances ◽  
Ccd Detectors ◽  
Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

Time and Latitude in South Africa

1972 ◽  
Vol 1 ◽  
pp. 27-38
Author(s):  
J. Hers
Keyword(s):  
South Africa ◽  
Cape Town ◽  
Astronomical Observations ◽  
Royal Observatory ◽  
The Republic ◽  
Astronomical Determination ◽  
Limited Accuracy ◽  
Better Than

In South Africa the modern outlook towards time may be said to have started in 1948. Both the two major observatories, The Royal Observatory in Cape Town and the Union Observatory (now known as the Republic Observatory) in Johannesburg had, of course, been involved in the astronomical determination of time almost from their inception, and the Johannesburg Observatory has been responsible for the official time of South Africa since 1908. However the pendulum clocks then in use could not be relied on to provide an accuracy better than about 1/10 second, which was of the same order as that of the astronomical observations. It is doubtful if much use was made of even this limited accuracy outside the two observatories, and although there may – occasionally have been a demand for more accurate time, it was certainly not voiced.

Localization of immunolabels by electron microscopy and image averaging

1983 ◽  
Vol 41 ◽  
pp. 282-283
Author(s):  
J. Frank ◽  
P.-Y. Sizaret ◽  
A. Verschoor ◽  
J. Lamy
Keyword(s):  
Electron Microscopy ◽  
Single Particle ◽  
Attachment Site ◽  
Uranyl Acetate ◽  
Limulus Polyphemus ◽  
Resolution Limit ◽  
Electron Microscopic ◽  
Image Averaging ◽  
Top View ◽  
Better Than

The accuracy with which the attachment site of immunolabels bound to macromolecules may be localized in electron microscopic images can be considerably improved by using single particle averaging. The example studied in this work showed that the accuracy may be better than the resolution limit imposed by negative staining (∽2nm).The structure used for this demonstration was a halfmolecule of Limulus polyphemus (LP) hemocyanin, consisting of 24 subunits grouped into four hexamers. The top view of this structure was previously studied by image averaging and correspondence analysis. It was found to vary according to the flip or flop position of the molecule, and to the stain imbalance between diagonally opposed hexamers (“rocking effect”). These findings have recently been incorporated into a model of the full 8 × 6 molecule.LP hemocyanin contains eight different polypeptides, and antibodies specific for one, LP II, were used. Uranyl acetate was used as stain. A total of 58 molecule images (29 unlabelled, 29 labelled with antl-LPII Fab) showing the top view were digitized in the microdensitometer with a sampling distance of 50μ corresponding to 6.25nm.

Closing the GAP—A 5Å Scanning Microscope

1969 ◽  
Vol 27 ◽  
pp. 6-7
Author(s):  
A. V. Crewe
Keyword(s):  
Normal Form ◽  
The Other ◽  
Resolving Power ◽  
Scanning Microscope ◽  
Conventional Microscope ◽  
Other Hand ◽  
Closing The Gap ◽  
Thermal Sources ◽  
Better Than ◽  
Transmission Microscope

We have become accustomed to differentiating between the scanning microscope and the conventional transmission microscope according to the resolving power which the two instruments offer. The conventional microscope is capable of a point resolution of a few angstroms and line resolutions of periodic objects of about 1Å. On the other hand, the scanning microscope, in its normal form, is not ordinarily capable of a point resolution better than 100Å. Upon examining reasons for the 100Å limitation, it becomes clear that this is based more on tradition than reason, and in particular, it is a condition imposed upon the microscope by adherence to thermal sources of electrons.

Electron Microscopic Observation of the Longitudinal Organization of Poly (p-Phenylene Terephthalamide) Fibers

1982 ◽  
Vol 40 ◽  
pp. 680-681
Author(s):  
Li Li-Sheng ◽  
L.F. Allard ◽  
W.C. Bigelow
Keyword(s):  
Electron Microscopy ◽  
Mechanical Properties ◽  
Scanning Electron Microscopy ◽  
Microscopic Observation ◽  
Electron Microscopic Observation ◽  
Electron Microscopic ◽  
Aromatic Polyamides ◽  
Radial Arrangement ◽  
Scanning Electron ◽  
Better Than

The aromatic polyamides form a class of fibers having mechanical properties which are much better than those of aliphatic polyamides. Currently, the accepted morphology of these fibers as proposed by M.G. Dobb, et al. is a radial arrangement of pleated sheets, with the plane of the pleats parallel to the axis of the fiber. We have recently obtained evidence which supports a different morphology of this type of fiber, using ultramicrotomy and ion-thinning techniques to prepare specimens for transmission and scanning electron microscopy.

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