Determination of urinary sulfate levels in horses and swine by conductometric titration

Two accurate, rapid and simple spectrophotometric and conductometric methods were developed for the determination of clomiphene citrate (CMP) and nefazodone HCl (NFZ), the proposed methods depends upon the reaction of ammonium reineckate with the two studied drugs to form stable precipitate of ion-pair complexes, which was dissolved in suitable solvent. The pink colored complexes were determined colorimetrically at 509, 523.6 nm, respectively. Using the conductometric titration, the studied drugs could be evaluated in 50% (v/v) acetone in the range 60.02-540.18 and 63.3-443.1 μg mL-1for clomiphene citrate and nefazodone HCl, respectively. While for spectrophotometric method the ranges were 0.2-1.8 and 0.2-1.6 mg mL-1for clomiphene citrate and nefazodone HCl respectively. Various experimental conditions were studied. The results obtained showed good recoveries with relative standard deviations of 0.759 and 0.552%. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical preparations and the results were favourably comparable with the official and reference methods. The molar combining ratio reveal that (1:1) (drug : reagent) ion associates were formed.

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Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species

Journal of Advanced Pharmacy Research ◽

10.21608/aprh.2018.5826 ◽

2018 ◽

Vol 2 (2) ◽

pp. 113-122

Author(s):

Fathy Salama ◽

Khalid Attia ◽

Ragab Said ◽

Ahmed El-Olemy ◽

Ahmed Abdel-raoof

Keyword(s):

Conductometric Titration ◽

Complex Species ◽

Solubility Products ◽

Trazodone Hydrochloride

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Simultaneous Differential Determination of Inorganic Acid and Nitrate in DMF Solution by Nonaqueous Conductometric Titration with Sodium Tetrahydroborate.

Journal of Oleo Science ◽

10.5650/jos.51.799 ◽

2002 ◽

Vol 51 (12) ◽

pp. 799-805

Author(s):

Takayoshi FUJINO ◽

Hayao NOGUCHI

Keyword(s):

Sodium Tetrahydroborate ◽

Conductometric Titration ◽

Inorganic Acid

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Development of a spectrophotometric method for determination of ions Cu (II) C N- (2-hydroxybenzoyl) -N '- (p-tosil)hydrazine in ammonia media

Вестник Пермского университета Серия «Химия» = Bulletin of Perm University CHEMISTRY ◽

10.17072/2223-1838-2021-2-103-113 ◽

2021 ◽

Vol 11 (2) ◽

pp. 103-113

Author(s):

Yulia B. Elchishcheva ◽

◽

Ksenia S. Gorbunova ◽

Petr T. Pavlov ◽

◽

...

Keyword(s):

Complex Compound ◽

Spectrophotometric Method ◽

Light Absorption ◽

Conductometric Titration ◽

Calibration Graph ◽

Optimal Time ◽

Optimal Conditions ◽

Molar Ratios ◽

Photometric Technique

A spectrophotometric method for the determination of Cu (II) ions with N- (2-hydroxybenzoyl) -N '- (p-tosyl) hydrazine (GBSH) in ammonia media has been developed. The optimal conditions for the formation of a complex compound are found: the wavelength of maximum light absorption; pH complexation; optimal time for color development; the amount of photometric reagent. Under optimal conditions of complexation of GBSG with Cu (Ⅱ) ions (λ = 401 nm, pH = 9.2, τ = 30 minutes, VGBSG = 3.75 ml), a calibration graph is constructed. The Bouguer-Lambert-Beer law is fulfilled in the range from 0.13 to 1.59 mg Cu (II) / 25 ml. The true molar light absorption coefficient of the complex compound of HBSG with Cu (Ⅱ) ions in the ammonia medium was 1480. The molar ratios in the solution of the complex compound were determined by the methods of saturation, shift of equilibria and conductometric titration - [Cu (Ⅱ)]: [HBSG] = 1: 1. According to Babko's method, the conditional constant of stability of the GBSG complex with Cu (Ⅱ) ions was calculated and it was 4.4 × 1010. The reproducibility and relative error of the developed photometric technique were determined by the method of mathematical statistics.

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