Proteomic Analysis of Interstitial Fluid in Bone Marrow Identified That Peroxiredoxin 2 Regulates H2O2Level of Bone Marrow during Aging

2010 ◽  
Vol 9 (8) ◽  
pp. 3812-3819 ◽  
Author(s):  
Wei Wang ◽  
Lantu Gou ◽  
Gang Xie ◽  
Aiping Tong ◽  
Fei He ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Proteomic Analysis ◽  
Interstitial Fluid ◽  
Peroxiredoxin 2

Proteomic analysis of human testicular interstitial fluid reflects disordered spermatogenesis in Klinefelter's syndrome

2014 ◽  
Author(s):  
Robert I McLachlan ◽  
Andrew N Stephens ◽  
Adam Rainczuk ◽  
Caroline Foo ◽  
Mark R Condina ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Interstitial Fluid ◽  
Klinefelter’S Syndrome ◽  
Klinefelter's Syndrome

Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation

PROTEOMICS ◽  
2006 ◽  
Vol 6 (8) ◽  
pp. 2564-2570 ◽  
Author(s):  
Yuichiro Yokoyama ◽  
Shuji Terai ◽  
Tsuyoshi Ishikawa ◽  
Koji Aoyama ◽  
Yohei Urata ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Liver Cirrhosis ◽  
Cell Transplantation ◽  
Bone Marrow Cell ◽  
Proteomic Analysis ◽  
Marrow Cell ◽  
Serum Marker ◽  
Bone Marrow Cell Transplantation ◽  
Marker Proteins

Adiponectin is down-regulated in bone marrow interstitial fluid in hematological malignancy

2015 ◽  
Vol 102 (3) ◽  
pp. 312-317 ◽  
Author(s):  
Fan-Yu Lin ◽  
Hung-Chang Wu ◽  
Kuo-Chen Cheng ◽  
Chao-Ling Tung ◽  
Chi-Pei Chang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Interstitial Fluid ◽  
Hematological Malignancy

scholarly journals Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Shenjie Li ◽  
Wei Xiang ◽  
Junjie Tian ◽  
Haorun Wang ◽  
Shuiwang Hu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Proteomic Analysis ◽  
Differentially Expressed ◽  
Migration And Invasion ◽  
Differentially Expressed Proteins ◽  
C6 Cells ◽  
2D Dige

Bone marrow-derived mesenchymal stem cells (BM-MSCs) display high tumor tropism and cause indirect effects through the cytokines they secrete. However, the effects of BM-MSCs on the biological behaviors of glioblastoma multiforme remain unclear. In this study, the conditioned medium from BM-MSCs significantly inhibited the proliferation of C6 cells ( P < 0.05 ) but promoted their migration and invasion ( P < 0.05 ). Two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) proteomic analysis revealed 17 proteins differentially expressed in C6 cells exposed to the BM-MSC-conditioned medium including five upregulated proteins and 12 downregulated proteins. Among these, six differentially expressed proteins (Calr, Set, Oat, Npm1, Ddah1, and Tardbp) were closely related to cell proliferation and differentiation, and nine proteins (Pdia6, Sphk1, Anxa4, Vim, Tuba1c, Actr1b, Actn4, Rap2c, and Tpm2) were associated with motility and the cytoskeleton, which may modulate the invasion and migration of tumor cells. Above all, by identifying the differentially expressed proteins using proteomics and bioinformatics analysis, BM-MSCs could be genetically modified to specifically express tumor-suppressive factors when BM-MSCs are to be used as tumor-selective targeting carriers in the future.

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