scholarly journals A Dynamic Range Compression and Three-Dimensional Peptide Fractionation Analysis Platform Expands Proteome Coverage and the Diagnostic Potential of Whole Saliva

2009 ◽  
Vol 8 (12) ◽  
pp. 5590-5600 ◽  
Author(s):  
Sricharan Bandhakavi ◽  
Matthew D. Stone ◽  
Getiria Onsongo ◽  
Susan K. Van Riper ◽  
Timothy J. Griffin
Keyword(s):  
Dynamic Range ◽  
Three Dimensional ◽  
Proteome Coverage ◽  
Dynamic Range Compression ◽  
Diagnostic Potential ◽  
Whole Saliva ◽  
Fractionation Analysis ◽  
Peptide Fractionation ◽  
Analysis Platform

Implantable hearing interfaces

2018 ◽  
Author(s):  
Torsten Lehmann ◽  
André van Schaik
Keyword(s):  
Cochlear Implants ◽  
Neural Activity ◽  
Dynamic Range ◽  
Systems Design ◽  
Fundamental Operation ◽  
Profound Hearing Loss ◽  
Biomedical Implant ◽  
Dynamic Range Compression ◽  
Hearing Function ◽  
Key Aspects

The chapter Implantable hearing interfaces describes the fundamental operation of a commonly available biohybrid system, the cochlear implant, or bionic ear. This neuro-stimulating biomedical implant is very successful in restoring hearing function to people with profound hearing loss. The fundamental operation of the biological cochlea is described and parallels are drawn between key aspects of the biological system and the biohybrid implementation: dynamic range compression, translation of sound to neural activity, and tonotopic mapping. Critical considerations are discussed for simultaneously meeting biological, surgical, and engineering restrictions in successful biohybrid systems design. Finally, challenges in present and future cochlear implants are outlined and directions of current research given.

Foundations of Advanced Neuroanatomy: Technical Guidelines for Specimen Preparation, Dissection, and 3D-Photodocumentation in a Surgical Anatomy Laboratory

2019 ◽  
Author(s):  
Luciano César PC Leonel ◽  
Lucas P. Carlstrom ◽  
Christopher S. Graffeo ◽  
Avital Perry ◽  
Carlos Diogenes Pinheiro-Neto ◽  
...  
Keyword(s):  
Oral Tradition ◽  
Dynamic Range ◽  
Tap Water ◽  
Three Dimensional ◽  
High Dynamic Range ◽  
Surgical Anatomy ◽  
Lessons Learned ◽  
Specimen Preparation ◽  
Technological Advances ◽  
Key Steps

Abstract Objective This study was aimed to provide a key update to the seminal works of Prof. Albert L. Rhoton Jr., MD, with particular attention to previously unpublished insights from the oral tradition of his fellows, recent technological advances including endoscopy, and high-dynamic range (HDR) photodocumentation, and, local improvements in technique, we have developed to optimize efficient neuroanatomic study. Methods Two formaldehyde-fixed cadaveric heads were injected with colored latex to demonstrate step-by-step specimen preparation for microscopic or endoscopic dissection. One formaldehyde-fixed brain was utilized to demonstrate optimal three-dimensional (3D) photodocumentation techniques. Results Key steps of specimen preparation include vessel cannulation and securing, serial tap water flushing, specimen drainage, vessel injection with optimized and color-augmented latex material, and storage in 70% ethanol. Optimizations for photodocumentation included the incorporation of dry black drop cloth and covering materials, an imaging-oriented approach to specimen positioning and illumination, and single-camera stereoscopic capture techniques, emphasizing the three-exposure-times-per-eye approach to generating images for HDR postprocessing. Recommended tools, materials, and technical nuances were emphasized throughout. Relative advantages and limitations of major 3D projection systems were comparatively assessed, with sensitivity to audience size and purpose specific recommendations. Conclusion We describe the first consolidated step-by-step approach to advanced neuroanatomy, including specimen preparation, dissection, and 3D photodocumentation, supplemented by previously unpublished insights from the Rhoton fellowship experience and lessons learned in our laboratories in the past years such that Prof. Rhoton's model can be realized, reproduced, and expanded upon in surgical neuroanatomy laboratories worldwide.

scholarly journals Ab initiostructure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector

2016 ◽  
Vol 72 (2) ◽  
pp. 236-242 ◽  
Author(s):  
E. van Genderen ◽  
M. T. B. Clabbers ◽  
P. P. Das ◽  
A. Stewart ◽  
I. Nederlof ◽  
...  
Keyword(s):  
Electron Diffraction ◽  
Room Temperature ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
Three Dimensional ◽  
Direct Methods ◽  
Liquid Nitrogen Temperature ◽  
High Dynamic Range ◽  
Electron Diffraction Data ◽  
High Signal

Until recently, structure determination by transmission electron microscopy of beam-sensitive three-dimensional nanocrystals required electron diffraction tomography data collection at liquid-nitrogen temperature, in order to reduce radiation damage. Here it is shown that the novel Timepix detector combines a high dynamic range with a very high signal-to-noise ratio and single-electron sensitivity, enablingab initiophasing of beam-sensitive organic compounds. Low-dose electron diffraction data (∼0.013 e− Å−2 s−1) were collected at room temperature with the rotation method. It was ascertained that the data were of sufficient quality for structure solution using direct methods using software developed for X-ray crystallography (XDS,SHELX) and for electron crystallography (ADT3D/PETS,SIR2014).

A Modified Multi Scale Retinex with Color Restoration Algorithm for Automatic Enhancement of Landsat-5 Remote Sensing Image

2011 ◽  
Vol 341-342 ◽  
pp. 893-897
Author(s):  
Gui Zhou Wang ◽  
Guo Jin He
Keyword(s):  
Image Enhancement ◽  
Dynamic Range ◽  
Color Constancy ◽  
Human Perception ◽  
Histogram Equalization ◽  
Image Processing Algorithm ◽  
Multi Scale ◽  
Dynamic Range Compression ◽  
Restoration Algorithm ◽  
Color Restoration

The retinex is a human perception based image processing algorithm which provides color constancy and dynamic range compression. The multi scale retinex with color restoration (MSRCR) has shown itself to be a very versatile automatic image enhancement algorithm that simultaneously provides dynamic range compression, color constancy, and color rendition. But the MSRCR results suffer from lower global brightness and partial color distortion. In order to improve the MSRCR method, this paper presents a modified MSRCR algorithm to Landsat-5 image enhancement considering percent liner stretch and histogram adjustment. Finally, the effect of modified MSRCR method on Landsat-5 image enhancement is analyzed and the comparison with other color adjustment methods such as gamma correction and histogram equalization is reported in the experimental results.

scholarly journals First multispacecraft ion measurements in and near the Earth’s magnetosphere with the identical Cluster ion spectrometry (CIS) experiment

2001 ◽  
Vol 19 (10/12) ◽  
pp. 1303-1354 ◽  
Author(s):  
H. Rème ◽  
C. Aoustin ◽  
J. M. Bosqued ◽  
I. Dandouras ◽  
B. Lavraud ◽  
...  
Keyword(s):  
Solar Wind ◽  
Angular Resolution ◽  
Dynamic Range ◽  
Ion Beam ◽  
Three Dimensional ◽  
Charge Composition ◽  
Ion Distribution ◽  
Central Plasma ◽  
Cluster Ion ◽  
High Level

Abstract. On board the four Cluster spacecraft, the Cluster Ion Spectrometry (CIS) experiment measures the full, three-dimensional ion distribution of the major magnetospheric ions (H+, He+, He++, and O+) from the thermal energies to about 40 keV/e. The experiment consists of two different instruments: a COmposition and DIstribution Function analyser (CIS1/CODIF), giving the mass per charge composition with medium (22.5°) angular resolution, and a Hot Ion Analyser (CIS2/HIA), which does not offer mass resolution but has a better angular resolution (5.6°) that is adequate for ion beam and solar wind measurements. Each analyser has two different sensitivities in order to increase the dynamic range. First tests of the instruments (commissioning activities) were achieved from early September 2000 to mid January 2001, and the operation phase began on 1 February 2001. In this paper, first results of the CIS instruments are presented showing the high level performances and capabilities of the instruments. Good examples of data were obtained in the central plasma sheet, magnetopause crossings, magnetosheath, solar wind and cusp measurements. Observations in the auroral regions could also be obtained with the Cluster spacecraft at radial distances of 4–6 Earth radii. These results show the tremendous interest of multispacecraft measurements with identical instruments and open a new area in magnetospheric and solar wind-magnetosphere interaction physics.Key words. Magnetospheric physics (magnetopause, cusp and boundary layers; magnetopheric configuration and dynamics; solar wind - magnetosphere interactions)

Nonlinear optical dynamic range compression with thin-film organic photorefractive material

2009 ◽  
Author(s):  
Bahareh Haji-saeed ◽  
Jed Khoury ◽  
Charles L. Woods ◽  
John Kierstead ◽  
Nasser Peyghambarian
Keyword(s):  
Thin Film ◽  
Nonlinear Optical ◽  
Dynamic Range ◽  
Dynamic Range Compression ◽  
Photorefractive Material
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