Population Studies of Vitamin D Binding Protein Microheterogeneity by Mass Spectrometry Lead to Characterization of its Genotype-Dependent O-Glycosylation Patterns

2008 ◽  
Vol 7 (9) ◽  
pp. 4143-4153 ◽  
Author(s):  
Chad R. Borges ◽  
Jason W. Jarvis ◽  
Paul E. Oran ◽  
Randall W. Nelson
Keyword(s):  
Mass Spectrometry ◽  
Vitamin D ◽  
Population Studies ◽  
Binding Protein ◽  
Vitamin D Binding Protein

Large-scale purification and characterization of non-glycosylated Gc globulin (vitamin D-binding protein) from plasma fraction IV

2006 ◽  
Vol 44 (1) ◽  
pp. 35 ◽  
Author(s):  
Maja Christiansen ◽  
Charlotte S. Jørgensen ◽  
Inga Laursen ◽  
Lisbeth B. Krogsøe ◽  
Peter Højrup ◽  
...  
Keyword(s):  
Vitamin D ◽  
Large Scale ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Purification And Characterization ◽  
Plasma Fraction

Screening and characterization of vitamin D binding protein variants

2014 ◽  
Vol 47 (12) ◽  
pp. 1149-1150
Author(s):  
Lei Fu ◽  
Betty Y.L. Wong ◽  
Chad R. Borges ◽  
Rashida Williams ◽  
Thomas O. Carpenter ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Protein Variants

scholarly journals Proteomics Approach for the Discovery of Rheumatoid Arthritis Biomarkers Using Mass Spectrometry

2019 ◽  
Vol 20 (18) ◽  
pp. 4368 ◽  
Author(s):  
Mun ◽  
Lee ◽  
Park ◽  
Kim ◽  
Lee ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mass Spectrometry ◽  
Vitamin D ◽  
Binding Protein ◽  
Joint Destruction ◽  
Protein Profiling ◽  
Serum Amyloid ◽  
Healthy Controls ◽  
Vitamin D Binding Protein ◽  
Proteomics Approach

Rheumatoid arthritis is an autoimmune disease that causes serious functional loss in patients. Early and accurate diagnosis of rheumatoid arthritis may attenuate its severity. Despite a diagnosis guideline in the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis, the practical difficulties in its diagnosis highlight the need of developing new methods for diagnosing rheumatoid arthritis. The current study aimed to identify rheumatoid arthritis diagnostic biomarkers by using a proteomics approach. Serum protein profiling was conducted using mass spectrometry, and five distinguishable biomarkers were identified therefrom. In the validation study, the five biomarkers were quantitatively verified by multiple reaction monitoring (MRM) analysis. Two proteins, namely serum amyloid A4 and vitamin D binding protein, showed high performance in distinguishing patients with rheumatoid arthritis from healthy controls. Logistic analysis was conducted to evaluate how accurately the two biomarkers distinguish patients with rheumatoid arthritis from healthy controls. The classification accuracy was 86.0% and 81.4% in patients with rheumatoid arthritis and in healthy controls, respectively. Serum amyloid A4 and vitamin D binding protein could be potential biomarkers related to the inflammatory response and joint destruction that accompany rheumatoid arthritis.

Characterization of additional vitamin D binding protein variants

2016 ◽  
Vol 159 ◽  
pp. 54-59 ◽  
Author(s):  
Lei Fu ◽  
Chad R. Borges ◽  
Douglas S. Rehder ◽  
Betty Y.L. Wong ◽  
Rashida Williams ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Protein Variants
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