Proteomic Study of the Microdissected Aortic Media in Human Thoracic Aortic Aneurysms

2014 ◽  
Vol 13 (11) ◽  
pp. 5071-5080 ◽  
Author(s):  
Muge Serhatli ◽  
Kemal Baysal ◽  
Ceyda Acilan ◽  
Eylem Tuncer ◽  
Seldag Bekpinar ◽  
...  
Keyword(s):  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
Proteomic Study ◽  
Aortic Media

scholarly journals Prefailure and Failure Mechanics of the Porcine Ascending Thoracic Aorta: Experiments and a Multiscale Model

2014 ◽  
Vol 136 (2) ◽  
Author(s):  
Sachin B. Shah ◽  
Colleen Witzenburg ◽  
Mohammad F. Hadi ◽  
Hallie P. Wagner ◽  
Janna M. Goodrich ◽  
...  
Keyword(s):  
Thoracic Aorta ◽  
Axial Direction ◽  
Multiscale Model ◽  
Aortic Aneurysms ◽  
Critical Threshold ◽  
Fiber Network ◽  
Thoracic Aortic Aneurysms ◽  
Aortic Media ◽  
The Media ◽  
Complex Architecture

Ascending thoracic aortic aneurysms (ATAA) have a high propensity for dissection, which occurs when the hemodynamic load exceeds the mechanical strength of the aortic media. Despite our recognition of this essential fact, the complex architecture of the media has made a predictive model of medial failure—even in the relatively simple case of the healthy vessel—difficult to achieve. As a first step towards a general model of ATAA failure, we characterized the mechanical behavior of healthy ascending thoracic aorta (ATA) media using uniaxial stretch-to-failure in both circumferential (n = 11) and axial (n = 11) orientations and equibiaxial extensions (n = 9). Both experiments demonstrated anisotropy, with higher tensile strength in the circumferential direction (2510 ± 439.3 kPa) compared to the axial direction (750 ± 102.6 kPa) for the uniaxial tests, and a ratio of 1.44 between the peak circumferential and axial loads in equibiaxial extension. Uniaxial tests for both orientations showed macroscopic tissue failure at a stretch of 1.9. A multiscale computational model, consisting of a realistically aligned interconnected fiber network in parallel with a neo-Hookean solid, was used to describe the data; failure was modeled at the fiber level, with an individual fiber failing when stretched beyond a critical threshold. The best-fit model results were within the 95% confidence intervals for uniaxial and biaxial experiments, including both prefailure and failure, and were consistent with properties of the components of the ATA media.

Cannulation of the Ascending Aorta in Left Thoracotomy for Thoracic Aortic Aneurysms

2007 ◽  
Vol 10 (1) ◽  
pp. E81-E83 ◽  
Author(s):  
Riza Turkoz ◽  
Oner Gulcan ◽  
Orhan Demirturk ◽  
Ayda Turkoz
Keyword(s):  
Ascending Aorta ◽  
Aortic Aneurysms ◽  
Left Thoracotomy ◽  
Thoracic Aortic Aneurysms

Complications After Endovascular Treatment of Thoracic Aortic Aneurysms

2003 ◽  
Vol 10 (4) ◽  
pp. 711-718 ◽  
Author(s):  
Reinhard Scharrer-Pamler ◽  
Thomas Kotsis ◽  
Xaver Kapfer ◽  
Johannes Görich ◽  
Karl-Heinz Orend ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms

Marfan Syndrome and Related Heritable Thoracic Aortic Aneurysms and Dissections

2015 ◽  
Vol 21 (28) ◽  
pp. 4061-4075 ◽  
Author(s):  
Julie Backer ◽  
Marjolijn Renard ◽  
Laurence Campens ◽  
Laura Mosquera ◽  
Anne Paepe ◽  
...  
Keyword(s):  
Marfan Syndrome ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms

Ultrasound diagnosis of dissecting thoracic aortic aneurysms: procedure with a handheld device and a video-illustrated case

2021 ◽  
Vol 51 (1) ◽  
pp. 10-15
Author(s):  
Kenneth V Iserson ◽  
Sri Devi Jagjit ◽  
Balram Doodnauth
Keyword(s):  
Aortic Dissection ◽  
Correct Diagnosis ◽  
Signs And Symptoms ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
Handheld Device ◽  
Thoracic Aortic Dissection ◽  
Threatening Condition ◽  
Life Threatening ◽  
Handheld Ultrasound

Acute thoracic aortic dissection is an uncommon, although not rare, life-threatening condition. With protean signs and symptoms that often suggest more common cardiac or pulmonary conditions, it can be difficult to diagnose. Ultrasound has proven useful in making the correct diagnosis. This case demonstrates that training gained using standard ultrasound machines can be easily and successfully adapted to newer handheld ultrasound devices. The examination technique using the handheld device is illustrated with photos and a video.

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