Proteomic Analysis of Proteins Related to Prognosis of Lung Adenocarcinoma

2014 ◽  
Vol 13 (11) ◽  
pp. 4686-4694 ◽  
Author(s):  
Akiko Okayama ◽  
Yohei Miyagi ◽  
Fumihiro Oshita ◽  
Mayuko Nishi ◽  
Yoshiyasu Nakamura ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Proteomic Analysis

scholarly journals Down-Regulation of 14-3-3 Isoforms and Annexin A5 Proteins in Lung Adenocarcinoma Induced by the Tobacco-Specific Nitrosamine NNK in the A/J Mouse Revealed by Proteomic Analysis

2009 ◽  
Vol 8 (8) ◽  
pp. 4050-4061 ◽  
Author(s):  
James D. Bortner ◽  
Arunangshu Das ◽  
Todd M. Umstead ◽  
Williard M. Freeman ◽  
Richard Somiari ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Proteomic Analysis ◽  
Annexin A5 ◽  
Down Regulation

Quantitative proteomic analysis identifying three annexins as lymph node metastasis-related proteins in lung adenocarcinoma

2010 ◽  
Vol 29 (1) ◽  
pp. 174-184 ◽  
Author(s):  
Ying-Fu Liu ◽  
Yong-Heng Chen ◽  
Mao-Yu Li ◽  
Peng-Fei Zhang ◽  
Fang Peng ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lung Adenocarcinoma ◽  
Proteomic Analysis ◽  
Quantitative Proteomic Analysis ◽  
Node Metastasis ◽  
Related Proteins

scholarly journals Erratum: Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualization of postoperative therapy

2008 ◽  
Vol 98 (12) ◽  
pp. 2013-2014
Author(s):  
J Maeda ◽  
T Hirano ◽  
A Ogiwara ◽  
S Akimoto ◽  
T Kawakami ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Proteomic Analysis ◽  
Stage I ◽  
Postoperative Therapy ◽  
Primary Lung Adenocarcinoma

Proteomic analysis of laser-microdissected paraffin-embedded tissues: (2) MRM assay for stage-related proteins upon non-metastatic lung adenocarcinoma

2010 ◽  
Vol 73 (6) ◽  
pp. 1100-1110 ◽  
Author(s):  
Toshihide Nishimura ◽  
Masaharu Nomura ◽  
Hiromasa Tojo ◽  
Hiroko Hamasaki ◽  
Tetsuya Fukuda ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Proteomic Analysis ◽  
Metastatic Lung ◽  
Related Proteins

Proteomic analysis of laser-microdissected paraffin-embedded tissues: (1) Stage-related protein candidates upon non-metastatic lung adenocarcinoma

2010 ◽  
Vol 73 (6) ◽  
pp. 1089-1099 ◽  
Author(s):  
Takeshi Kawamura ◽  
Masaharu Nomura ◽  
Hiromasa Tojo ◽  
Kiyonaga Fujii ◽  
Hiroko Hamasaki ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Proteomic Analysis ◽  
Related Protein ◽  
Metastatic Lung

Kaempferol-3-O-rutinoside, a flavone derived from Tetrastigma hemsleyanum, suppresses lung adenocarcinoma via the calcium signaling pathway

2021 ◽  
Author(s):  
Yonglu Li ◽  
Xin Yu ◽  
Yaxuan Wang ◽  
Xiaodong Zheng ◽  
Qiang Chu
Keyword(s):  
Lung Adenocarcinoma ◽  
Calcium Signaling ◽  
Signaling Pathway ◽  
Proteomic Analysis ◽  
Cytoskeletal Proteins ◽  
Tetrastigma Hemsleyanum ◽  
Calcium Signaling Pathway

An elder is fishing on the sea, iTRAQ-based proteomic analysis is his gear, and he explores the mechanism of THTF anti-tumor effects, as DEPs are most accumulated in the calcium signaling pathway (CSP), closely associated with cytoskeletal proteins.

scholarly journals Proteomics of the radioresistant phenotype in H1299 cells: SLC2A1 as a radiosensitivity marker

2021 ◽  
Author(s):  
Xiaoling Xie ◽  
Yang Li ◽  
Zhiwu Liu ◽  
Yan Tang
Keyword(s):  
Cell Cycle ◽  
Lung Adenocarcinoma ◽  
Radiation Resistance ◽  
Proteomic Analysis ◽  
Malignant Tumors ◽  
Viable Cell ◽  
High Dose ◽  
H1299 Cell ◽  
Photon Irradiation ◽  
Cell Percentage

Abstract Background: Radiotherapy is a main method for the treatment of malignant tumors. However, radiation resistance of tumor cells is the main reason for poor prognosis. The purpose of this study was to screen the differentially expressed protein (DEP), and its key protein related to radiation resistance in photon-resistant lung adenocarcinoma cell line H1299. Methods: In this study, we investigated the cell viability and colony formation were examined to evaluate the potent proliferation-inhibiting effect of photo therapy on the H1299 cells. Flow cytometry was used to detect apoptosis. Further we selected the appropriate irradiation dose after photon irradiation of radioresistant cell H1299 for screening and validation of radioresistance-related DEPs by proteomic analysis. Furthermore, we also studied the SLC2A1 and irradiation sensitivity potential. Results: The results showed a dose‑dependent decrease of viable cell percentage following high dose of exposure (at dose of 8 and 10 Gy), and a prolonged the prolongation of H1299 cell cycle arrest, induced apoptosis. Proteomic analysis using iTRAQ revealed a total of 46 DEPs were identified including 30 up-regulated and 16 down-regulated DEPs in inhibition. Western blotting validated the respective changes in protein expression. DEPs were significantly associated with five-year survival in patients with lung adenocarcinoma. In addition, after knocking down SLC2A1, it was found that 4Gy radiation could significantly inhibit the proliferation of H1299 cells and regulate G2 phase arrest of cell cycle by down-regulating Cdk2. Conclusions: These findings suggest the ITGA6,EIF4G1 and SLC2A1 protein is closely related to radiation resistance of lung adenocarcinoma, and SLC2A1 expression is significantly related to patient survival, so it can increase the sensitivity of H1299 cells to photon rays.

scholarly journals Proteomic Analysis of Cytokeratin Isoforms Uncovers Association with Survival in Lung Adenocarcinoma

Neoplasia ◽  
2002 ◽  
Vol 4 (5) ◽  
pp. 440-448 ◽  
Author(s):  
Tarek G. Gharib ◽  
Guoan Chen ◽  
Hong Wang ◽  
Chiang-Ching Huang ◽  
Michael S. Prescott ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Proteomic Analysis
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