Spatial and Temporal Effects in Protein Post-translational Modification Distributions in the Developing Mouse Brain

2013 ◽  
Vol 13 (1) ◽  
pp. 260-267 ◽  
Author(s):  
Alistair V. G. Edwards ◽  
Gregory J. Edwards ◽  
Veit Schwämmle ◽  
Henrik Saxtorph ◽  
Martin R. Larsen
Keyword(s):  
Mouse Brain ◽  
Post Translational Modification ◽  
Temporal Effects ◽  
Developing Mouse Brain

scholarly journals Immunological discrimination of β-tubulin isoforms in developing mouse brain. Post-translational modification of non-class-III β-tubulins

1992 ◽  
Vol 288 (3) ◽  
pp. 919-924 ◽  
Author(s):  
I Linhartová ◽  
P Dráber ◽  
E Dráberová ◽  
V Viklický
Keyword(s):  
Mouse Brain ◽  
Specific Class ◽  
Class Iii ◽  
Post Translational Modification ◽  
Beta Tubulin ◽  
Developmentally Regulated ◽  
Post Translational Modifications ◽  
Tubulin Isotypes ◽  
Tubulin Isoforms ◽  
Developing Mouse Brain

Individual beta-tubulin isoforms in developing mouse brain were characterized using immunoblotting, after preceding high-resolution isoelectric focusing, with monoclonal antibodies against different structural regions of beta-tubulin. Some of the antibodies reacted with a limited number of tubulin isoforms in all stages of brain development and in HeLa cells. The epitope for the TU-14 antibody was located in the isotype-defining domain and was present on the beta-tubulin isotypes of classes I, II and IV, but absent on the neuron-specific class-III isotype. The data suggest that non-class-III beta-tubulins in mouse brain are substrates for developmentally regulated post-translational modifications and that beta-tubulins of non-neuronal cells are also post-translationally modified.

Author response for "Hemovasculogenic origin of blood vessels in the developing mouse brain"

2020 ◽  
Author(s):  
Miguel A. Gama Sosa ◽  
Rita De Gasperi ◽  
Gissel M. Perez ◽  
Patrick R. Hof ◽  
Gregory A. Elder
Keyword(s):  
Blood Vessels ◽  
Mouse Brain ◽  
Author Response ◽  
Developing Mouse Brain

Effects of intrauterine inflammation on developing mouse brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S110-S110
Author(s):  
Xiaoyang Wang ◽  
Carina Mallard ◽  
Bo Jacobsson ◽  
Henrik Hagberg
Keyword(s):  
Mouse Brain ◽  
Developing Mouse Brain

scholarly journals Molecular architecture of the developing mouse brain

Nature ◽  
2021 ◽  
Author(s):  
Gioele La Manno ◽  
Kimberly Siletti ◽  
Alessandro Furlan ◽  
Daniel Gyllborg ◽  
Elin Vinsland ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Molecular Architecture ◽  
Developing Mouse Brain

scholarly journals Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
María del Pilar Madrigal ◽  
Sandra Jurado
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Brain ◽  
Arginine Vasopressin ◽  
3D Imaging ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cellular Resolution ◽  
Developing Mouse Brain ◽  
Developmental Dynamics ◽  
Appropriate Social Behaviors

AbstractOxytocin (OXT) and arginine vasopressin (AVP) support a broad range of behaviors and homeostatic functions including sex-specific and context-appropriate social behaviors. Although the alterations of these systems have been linked with social-related disorders such as autism spectrum disorder, their formation and developmental dynamics remain largely unknown. Using novel brain clearing techniques and 3D imaging, we have reconstructed the specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain with unprecedented cellular resolution. A systematic quantification indicates that OXT and AVP neurons in the hypothalamus display distinctive developmental dynamics and high cellular plasticity from embryonic to early postnatal stages. Our findings reveal new insights into the specification and consolidation of neuropeptidergic systems in the developing CNS.

scholarly journals Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Yuen Gao ◽  
Natalia Duque-Wilckens ◽  
Mohammad B. Aljazi ◽  
Yan Wu ◽  
Adam J. Moeser ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Molecular Mechanisms ◽  
Gene Mutations ◽  
Autism Spectrum ◽  
Normal Brain ◽  
Critical Function ◽  
Developmental Defects ◽  
Neurodevelopmental Disease ◽  
Developing Mouse Brain

AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disease associated with various gene mutations. Recent genetic and clinical studies report that mutations of the epigenetic gene ASH1L are highly associated with human ASD and intellectual disability (ID). However, the causality and underlying molecular mechanisms linking ASH1L mutations to genesis of ASD/ID remain undetermined. Here we show loss of ASH1L in the developing mouse brain is sufficient to cause multiple developmental defects, core autistic-like behaviors, and impaired cognitive memory. Gene expression analyses uncover critical roles of ASH1L in regulating gene expression during neural cell development. Thus, our study establishes an ASD/ID mouse model revealing the critical function of an epigenetic factor ASH1L in normal brain development, a causality between Ash1L mutations and ASD/ID-like behaviors in mice, and potential molecular mechanisms linking Ash1L mutations to brain functional abnormalities.

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