scholarly journals Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma

2011 ◽  
Vol 10 (9) ◽  
pp. 4314-4324 ◽  
Author(s):  
Cláudia M. Rocha ◽  
Joana Carrola ◽  
António S. Barros ◽  
Ana M. Gil ◽  
Brian J. Goodfellow ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Blood Plasma ◽  
Metabolic Signatures

scholarly journals Screening of lung cancer biomarker-proteins with a multiplex electrochemical sensor system based on aptamers

2018 ◽  
Vol 17 (3) ◽  
pp. 13-21
Author(s):  
Yu. E. Glazyrin ◽  
A. V. Shabalina ◽  
K. A. Ryginskaya ◽  
S. S. Zamay ◽  
V. A. Kolovski ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Blood Plasma ◽  
Simultaneous Detection ◽  
Selection Procedure ◽  
Cancer Tissue ◽  
Dna Aptamers ◽  
Affinity Enrichment ◽  
In Blood Plasma

The aimof this work is the development and demonstration of the method of simultaneous detection of several biomarkers of lung cancer in the blood plasma of patients using a multiplex electrochemical testing system based on DNA aptamers. DNA aptamers are a new class of synthetic affinity probes obtained by in vitro or in vivo selection procedure by the systematic evolution of ligands by exponential enrichment (SELEX).Materials and methods.A set of aptamers obtained previously by selection for postoperative lung cancer tissue was used to create a multiplex electrochemical biochip. Identification of aptamer target proteins was performed using a modified affinity enrichment method (AptaBID). Molecular targets for the used set of aptamers to lung cancer were defined as vimentin, defensin, a light chain of myosin, tubulin alpha 1-B, neutrophil elastase and A1 elongation factor 1.Measurements of the presence of these biomarker proteins in blood plasma were carried out using electrochemical detection. The difference between peak heights before and after plasma deposition on the electrodes modified by aptamers was considered as a response of the system to the presence of protein onco-markers in blood plasma. Blood plasma of healthy volunteers was used as control.Results. Research showed that in the blood plasma of all the patients with lung cancer the content of biomarker proteins that bind to aptamers on electrode surfaces was increased. The increased content of these proteins in the blood plasma of patients suggests the presence of invasiveness and metastasis of tumors and their chemo-resistance.

scholarly journals Validation of 1H-Nmr-Based Metabolomics As a Tool to Detect Lung Cancer in Human Blood Plasma

2014 ◽  
Vol 25 ◽  
pp. iv406 ◽  
Author(s):  
M. Thomeer ◽  
E. Louis ◽  
L. Mesotten ◽  
K. Vanhove ◽  
K. Vandeurzen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Blood Plasma ◽  
1H Nmr ◽  
Human Blood ◽  
Human Blood Plasma

scholarly journals Raman spectroscopy detects metabolic signatures of radiation response and hypoxic fluctuations in non-small cell lung cancer

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Samantha J. Van Nest ◽  
Leah M. Nicholson ◽  
Nils Pavey ◽  
Mathew N. Hindi ◽  
Alexandre G. Brolo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Raman Spectroscopy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Radiation Response ◽  
Small Cell Lung ◽  
Metabolic Signatures

scholarly journals Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0223840
Author(s):  
Andrzej Ciereszko ◽  
Mariola A. Dietrich ◽  
Mariola Słowińska ◽  
Joanna Nynca ◽  
Michał Ciborowski ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Blood Plasma ◽  
Cancer Patients ◽  
Lung Cancer Patients ◽  
2D Dige

Metabolic signatures of four major histological types of lung cancer cells

Metabolomics ◽  
2018 ◽  
Vol 14 (9) ◽  
Author(s):  
Swee Ling Lim ◽  
Zhunan Jia ◽  
Yonghai Lu ◽  
Hui Zhang ◽  
Cheng Teng Ng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Histological Types ◽  
Metabolic Signatures

Application of cysteamine-capped gold nanoparticles for early detection of lung cancer-specific miRNA (miR-25) in human blood plasma

2017 ◽  
Vol 9 (25) ◽  
pp. 3852-3861 ◽  
Author(s):  
Amineh Asadzadeh-Firouzabadi ◽  
Hamid R. Zare
Keyword(s):  
Lung Cancer ◽  
Gold Nanoparticles ◽  
Early Detection ◽  
Blood Plasma ◽  
Human Blood ◽  
Human Blood Plasma

In this study, we designed a nanogenosensor based on cysteamine-capped gold nanoparticles (Cys-AuNPs) that makes it possible to detect the miRNA (miR-25) related to lung cancer.

Metabolic profiling of human lung cancer blood plasma using 1H NMR spectroscopy

2017 ◽  
Author(s):  
Daria Kokova ◽  
Natalia Dementeva ◽  
Oleg Kotelnikov ◽  
Anastasia Ponomaryova ◽  
Nadezhda Cherdyntseva ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Nmr Spectroscopy ◽  
Blood Plasma ◽  
1H Nmr ◽  
Metabolic Profiling ◽  
1H Nmr Spectroscopy ◽  
Human Lung ◽  
Human Lung Cancer
Sign in / Sign up

Export Citation Format

Share Document