In Vitro Metabonomic Study Detects Increases in UDP-GlcNAc and UDP-GalNAc, as Early Phase Markers of Cisplatin Treatment Response in Brain Tumor Cells

2011 ◽  
Vol 10 (8) ◽  
pp. 3493-3500 ◽  
Author(s):  
Xiaoyan Pan ◽  
Martin Wilson ◽  
Ladan Mirbahai ◽  
Carmel McConville ◽  
Theodoros N. Arvanitis ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Treatment Response ◽  
Tumor Cells ◽  
Early Phase ◽  
Brain Tumor Cells

BCNU-modification of the in vitro radiation response in 9L brain tumor cells of rats

1977 ◽  
Vol 2 (1-2) ◽  
pp. 79-88 ◽  
Author(s):  
Kenneth T. Wheeler ◽  
Dennis F. Deen ◽  
Charles B. Wilson ◽  
Mary E. Williams ◽  
Sandra Sheppard
Keyword(s):  
Brain Tumor ◽  
Tumor Cells ◽  
Radiation Response ◽  
Brain Tumor Cells

Monoclonal antibody 2C5-mediated binding of liposomes to brain tumor cells in vitro and in subcutaneous tumor model in vivo

2005 ◽  
Vol 13 (6) ◽  
pp. 337-343 ◽  
Author(s):  
Bhawna Gupta ◽  
Tatiana S. Levchenko ◽  
Dmitry A. Mongayt ◽  
Vladimir P. Torchilin
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumor ◽  
Tumor Cells ◽  
Tumor Model ◽  
Subcutaneous Tumor ◽  
Brain Tumor Cells

In vitro influence of hypoxia on bioluminescence imaging in brain tumor cells

2007 ◽  
Author(s):  
Eduardo H. Moriyama ◽  
Mark Jarvi ◽  
Mark Niedre ◽  
Joseph D. Mocanu ◽  
Yumi Moriyama ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Cells ◽  
Bioluminescence Imaging ◽  
Brain Tumor Cells

Development of Resistance to Antitumor Chloroethylnitrosoureas in Vitro in Brain Tumor Cells

1992 ◽  
Vol 31 (7) ◽  
pp. 755-759 ◽  
Author(s):  
Katsuyoshi Mineura ◽  
Yuko Ishiyama ◽  
Masayoshi Kowada
Keyword(s):  
Brain Tumor ◽  
Tumor Cells ◽  
Development Of Resistance ◽  
Brain Tumor Cells

Antitumor activity against established intracerebral gliomas exhibited by cytotoxic T lymphocytes, but not by lymphokine-activated killer cells

1992 ◽  
Vol 77 (5) ◽  
pp. 757-762 ◽  
Author(s):  
Frank P. Holladay ◽  
Teresa Heitz ◽  
Gary W. Wood
Keyword(s):  
Brain Tumor ◽  
T Lymphocytes ◽  
Tumor Cells ◽  
Cytotoxic T Lymphocytes ◽  
Lak Cells ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
Brain Tumor Cells

✓ Specific immune responses against malignant brain tumors have been difficult to demonstrate. Moreover, immunotherapy has met with little success, despite using lymphocytes with high levels of cytotoxicity against brain tumor cells. Lymphokine-activated killer (LAK) cells that nonspecifically kill brain tumor cells are produced by stimulating resting precursors with high concentrations of interleukin-2 (IL-2). Cytotoxic T lymphocytes that specifically kill brain tumor cells are produced by stimulating antigen receptor-positive immune-cell precursors with tumor cells. In an attempt to gain insight into immune cell function against brain tumors, the present study compared the in vitro and in vivo activities of LAK cells and cytotoxic T lymphocytes produced against RT2, a fast-growing rat glioma cell line. Lymphokine-activated killer cells were produced by stimulating normal rat spleen cells with 1000 units of IL-2, and RT2-specifie cytotoxic T lymphocytes were produced by priming them in vivo with RT2 and Corynebacterium parvum and restimulating primed spleen cells with RT2 in vitro. Lymphokine-activated killer cells were highly cytotoxic for a panel of syngeneic and allogeneic brain tumor and non-brain tumor target cells, including RT2, as measured in a 4-hour 51Cr release assay. Cytotoxic T lymphocytes were highly cytotoxic only for syngeneic brain tumor target cells. Lymphokine-activated killer cells and cytotoxic T lymphocytes were tested for in vivo antitumor activity against intracerebral RT2 by intravenous adoptive transfer of activated lymphocytes. Untreated rats died in approximately 2 weeks. Lymphokine-activated killer cells plus IL-2 failed to affect survival when treatment was initiated as early as 1 day following tumor inoculation. Cytotoxic T lymphocytes and IL-2 administered as late as Day 5 rejected progressing intracerebral tumor. Thus, although both cytotoxic T lymphocytes and LAK cells exhibited high levels of in vitro killing of glioma cells, only cytotoxic T lymphocytes rejected progressing intracerebral tumors.

Effect of dibutyryl cAMP on cell cycle progression of rat brain tumor cells in vitro

In Vitro ◽  
1978 ◽  
Vol 14 (2) ◽  
pp. 174-179 ◽  
Author(s):  
Kazuhiro Nomura ◽  
Takao Hoshino ◽  
Kathy Knebel ◽  
Marvin Barker
Keyword(s):  
Cell Cycle ◽  
Brain Tumor ◽  
Rat Brain ◽  
Tumor Cells ◽  
Cell Cycle Progression ◽  
Dibutyryl Camp ◽  
Cycle Progression ◽  
Brain Tumor Cells ◽  
Rat Brain Tumor

Prediction of the relative in vitro sensitivity of 9L rat brain tumor cells to nitrosoureas by the sister chromatid exchange assay

Life Sciences ◽  
1984 ◽  
Vol 35 (15) ◽  
pp. 1611-1614 ◽  
Author(s):  
Philip J. Tofilon ◽  
Massimo A. Gerosa ◽  
Mark L. Rosenblum ◽  
William J. Bodell ◽  
Dennis F. Deen
Keyword(s):  
Brain Tumor ◽  
Rat Brain ◽  
Tumor Cells ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
In Vitro Sensitivity ◽  
Brain Tumor Cells ◽  
Rat Brain Tumor
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