Identification of Novel Human Adipocyte Secreted Proteins by Using SGBS Cells

2010 ◽  
Vol 9 (10) ◽  
pp. 5389-5401 ◽  
Author(s):  
Anja Rosenow ◽  
Tabiwang N. Arrey ◽  
Freek G. Bouwman ◽  
Jean-Paul Noben ◽  
Martin Wabitsch ◽  
...  
Keyword(s):  
Secreted Proteins ◽  
Human Adipocyte ◽  
Sgbs Cells

scholarly journals SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chia Rou Yeo ◽  
Madhur Agrawal ◽  
Shawn Hoon ◽  
Asim Shabbir ◽  
Manu Kunaal Shrivastava ◽  
...  
Keyword(s):  
Comparative Study ◽  
Human Adipocyte ◽  
Sgbs Cells

A new human adipocyte model derived from a PTEN-deficient lipoma

2013 ◽  
Vol 121 (03) ◽  
Author(s):  
A Garten ◽  
F Kässner ◽  
GL Schmid ◽  
K Landgraf ◽  
A Tannert ◽  
...  
Keyword(s):  
Human Adipocyte

Immunological Evidence for Prothrombin in Human Platelets

1986 ◽  
Vol 55 (02) ◽  
pp. 268-270
Author(s):  
R J Alexander
Keyword(s):  
Electrophoretic Mobility ◽  
Platelet Activation ◽  
Double Diffusion ◽  
Human Platelets ◽  
Secreted Proteins ◽  
Platelet Surface ◽  
Activated Platelets ◽  
Similar Protein ◽  
Diffusion Assay ◽  
Supernatant Solution

SummaryAn attempt was made to isolate from plasma the platelet surface substrate for thrombin, glycoprotein V (GPV), because a GPV antigen was reported to be present in plasma (3). Plasma fractionation based on procedures for purification of GPV from platelets revealed a thrombin-sensitive protein with appropriate electrophoretic mobility. The protein was purified; an antiserum against it i) reacted with detergent-solubilized platelet proteins or secreted proteins in a double diffusion assay, ii) adsorbed a protein from the supernatant solution of activated platelets, and iii) inhibited thrombin-induced platelet activation, but the antiserum did not adsorb labeled GPV. The purified protein was immunochemically related to prothrombin rather than to GPV. Other antibodies against prothrombin were also able to adsorb a protein from platelets. It is concluded that 1) plasma does not contain appreciable amounts of GPV, and 2) platelets contain prothrombin or an immunochemically similar protein.

Genome-wide analysis of the secreted proteins of phytophthora infestans

2011 ◽  
Vol 33 (7) ◽  
pp. 785-793 ◽  
Author(s):  
Xiao-Gang ZHOU ◽  
Si-Ming HOU ◽  
Duo-Wen CHEN ◽  
Nan TAO ◽  
Yu-Mei DING ◽  
...  
Keyword(s):  
Phytophthora Infestans ◽  
Secreted Proteins ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Categorization of Orthologous Gene Clusters in 92 Ascomycota Genomes Reveals Functions Important for Phytopathogenicity

2021 ◽  
Vol 7 (5) ◽  
pp. 337
Author(s):  
Daniel Peterson ◽  
Tang Li ◽  
Ana M. Calvo ◽  
Yanbin Yin
Keyword(s):  
Comparative Genomics ◽  
Orthologous Gene ◽  
Gene Clusters ◽  
Phytopathogenic Fungi ◽  
Secreted Proteins ◽  
Economic Losses ◽  
Comparative Genomic ◽  
Signal Peptides ◽  
Comparative Genomics Analysis

Phytopathogenic Ascomycota are responsible for substantial economic losses each year, destroying valuable crops. The present study aims to provide new insights into phytopathogenicity in Ascomycota from a comparative genomic perspective. This has been achieved by categorizing orthologous gene groups (orthogroups) from 68 phytopathogenic and 24 non-phytopathogenic Ascomycota genomes into three classes: Core, (pathogen or non-pathogen) group-specific, and genome-specific accessory orthogroups. We found that (i) ~20% orthogroups are group-specific and accessory in the 92 Ascomycota genomes, (ii) phytopathogenicity is not phylogenetically determined, (iii) group-specific orthogroups have more enriched functional terms than accessory orthogroups and this trend is particularly evident in phytopathogenic fungi, (iv) secreted proteins with signal peptides and horizontal gene transfers (HGTs) are the two functional terms that show the highest occurrence and significance in group-specific orthogroups, (v) a number of other functional terms are also identified to have higher significance and occurrence in group-specific orthogroups. Overall, our comparative genomics analysis determined positive enrichment existing between orthogroup classes and revealed a prediction of what genomic characteristics make an Ascomycete phytopathogenic. We conclude that genes shared by multiple phytopathogenic genomes are more important for phytopathogenicity than those that are unique in each genome.

scholarly journals Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation

2021 ◽  
Vol 156 ◽  
pp. 106730
Author(s):  
Alexandra Schaffert ◽  
Laura Krieg ◽  
Juliane Weiner ◽  
Rita Schlichting ◽  
Elke Ueberham ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Adipocyte Differentiation ◽  
Human Adipocyte
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