“Turnover Proteome” of Human Atrial Trabeculae

2007 ◽  
Vol 6 (11) ◽  
pp. 4458-4468 ◽  
Author(s):  
Florian M. Lampert ◽  
Peter Matt ◽  
Martin Grapow ◽  
Ivan Lefkovits ◽  
Hans-Reinhard Zerkowski ◽  
...  
Keyword(s):  
Human Atrial Trabeculae

Effects of hypoxia, simulated ischemia and reoxygenation on the contractile function of human atrial trabeculae

1996 ◽  
Vol 160-161 (1) ◽  
pp. 143-151 ◽  
Author(s):  
Andreas Lammerich ◽  
J�rgen Bohm ◽  
Ingolf Schimke ◽  
Kay-Dietrich Wagner ◽  
Eberhard Storch ◽  
...  
Keyword(s):  
Contractile Function ◽  
Simulated Ischemia ◽  
Human Atrial Trabeculae

Effects of hypoxia, simulated ischemia and reoxygenation on the contractile function of human atrial trabeculae

1996 ◽  
pp. 143-151
Author(s):  
Andreas Lammerich ◽  
Jürgen Böhm ◽  
Ingolf Schimke ◽  
Kay-Dietrich Wagner ◽  
Eberhard Storch ◽  
...  
Keyword(s):  
Contractile Function ◽  
Simulated Ischemia ◽  
Human Atrial Trabeculae

scholarly journals Postconditioning the Heart: Analysis of Experimental and Clinical Data

2016 ◽  
Vol 71 (1) ◽  
pp. 25-30 ◽  
Author(s):  
L. N. Maslov ◽  
S. Yu. Tsibul'nikov ◽  
A. V. Mukhomedzyanov ◽  
A. S. Semenotsov ◽  
A. V. Tsepokina ◽  
...  
Keyword(s):  
Diabetes Type 2 ◽  
Experimental Atherosclerosis ◽  
Cardioprotective Effect ◽  
Clinical Observations ◽  
Extubation Time ◽  
Patients With Diabetes ◽  
Apoptotic Effect ◽  
Human Atrial Trabeculae ◽  
Rats And Mice

Experimental atherosclerosis and hypercholesterolemia may reduce or eliminate the infarct-limiting and anti-apoptotic effect of postconditioning (PC). Experiments in rats and mice indicate that the PC may be quite effective in patients with diabetes type 2 or metabolic syndrome. Experimental data suggest that hypertension or the past myocardial infarction is not an obstacle for the implementation of cardioprotective effect of PC. It was established that that aging does not preclude the implementation of PC cardioprotective effect. Inotropic effect of IP can simulate on isolated human atrial trabeculae. The clinical observations suggest that the PC in patients with tetralogy of Fallot and patients with operations on the valves improves the outcome of cardiac surgery. It was established that PC in these patients reduces the intensity of reperfusion necrosis of cardiomyocytes, improves the pumping function of the heart, reduces the inotropic support, shorten the extubation time.

Human atrial trabeculae superfused with human serum are resistant to the acute effects of exposure to Fe3+

1992 ◽  
Vol 24 ◽  
pp. 127
Author(s):  
Costas Pantos ◽  
Michael S Marber ◽  
Derek M Yellon ◽  
John B Ponter ◽  
Wilfred B Pugsley ◽  
...  
Keyword(s):  
Human Serum ◽  
Acute Effects ◽  
Human Atrial Trabeculae

The Effect of Oxytocin on the Contractile Force of Human Atrial Trabeculae

1998 ◽  
Vol 86 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Ola P. Rosaeg ◽  
Nicholas J. Cicutti ◽  
Rosalind S. Labow
Keyword(s):  
Contractile Force ◽  
Human Atrial Trabeculae

Ischemic preconditioning of human myocardium: protein kinase C mediates a permissive role for alpha 1-adrenoceptors

1997 ◽  
Vol 273 (2) ◽  
pp. H902-H908 ◽  
Author(s):  
J. C. Cleveland ◽  
D. R. Meldrum ◽  
R. T. Rowland ◽  
B. S. Cain ◽  
X. Meng ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Ischemic Preconditioning ◽  
Kinase Activity ◽  
Coronary Bypass ◽  
Creatine Kinase Activity ◽  
Kinase C ◽  
Pre Treatment ◽  
Human Atrial Trabeculae

The purposes of this study were to determine whether ischemic preconditioning (IPC) in human atrial trabeculae is mediated by alpha 1-adrenoceptors and protein kinase C (PKC) and whether the protection of IPC is replicated with alpha 1-adrenoceptor stimulation [alpha 1-adrenoceptor preconditioning (alpha 1-PC)]. Atrial trabeculae were obtained during coronary bypass surgery. The trabeculae were suspended in organ baths containing Tyrode solution and field stimulated at 1 Hz, and developed force was recorded. The trabeculae underwent 45 min of simulated ischemia (SI) and 120 min of reperfusion (I/R injury). IPC trabeculae received transient SI before I/R injury, alpha 1-Adrenoceptor blockade with BE-2254 and PKC inhibition with chelerythrine were independently combined with IPC before I/R injury. alpha 1-PC before I/R was examined with alpha 1-adrenergic agonist (phenylephrine) pre-treatment. Improved recovery of developed force and higher tissue creatine kinase activity were present in IPC trabeculae, and the protective effect of IPC was eliminated with either alpha 1-adrenoceptor blockade or PKC inhibition. alpha 1-PC trabeculae also exhibited enhanced functional recovery after I/R injury but lacked preservation of tissue creatine kinase activity. PKC inhibition eliminated the functional protection of alpha 1-PC. These results suggest that, in human atrial trabeculae, alpha 1-adrenoceptors and PKC mediate, in part, the functional and tissue CK preservation conferred by IPC, but alpha 1-PC does not replicate the protection of IPC.

Triggered propagated contractions in human atrial trabeculae

1993 ◽  
Vol 27 (10) ◽  
pp. 1831-1835 ◽  
Author(s):  
M. C G Daniels ◽  
T. Kieser ◽  
H. E D J ter Keurs
Keyword(s):  
Human Atrial Trabeculae

scholarly journals The Effect of Oxytocin on the Contractile Force of Human Atrial Trabeculae

1998 ◽  
Vol 86 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Ola P. Rosaeg ◽  
Nicholas J. Cicutti ◽  
Rosalind S. Labow
Keyword(s):  
Contractile Force ◽  
Human Atrial Trabeculae

Comparision of the Inotropic Effects of Levosimendan, Rolipram, and Dobutamine on Human Atrial Trabeculae

2004 ◽  
Vol 44 (5) ◽  
pp. 622-625 ◽  
Author(s):  
Coskun Usta ◽  
Paolo Emilio Puddu ◽  
Ugo Papalia ◽  
Vincenzo De Santis ◽  
Domenico Vitale ◽  
...  
Keyword(s):  
Inotropic Effects ◽  
Human Atrial Trabeculae
Sign in / Sign up

Export Citation Format

Share Document