Development of a Modeling-Based Strategy for the Safe and Effective Scale-up of Highly Energetic Hydrogenation Reactions

2014 ◽  
Vol 18 (12) ◽  
pp. 1828-1835 ◽  
Author(s):  
Christopher W. Mitchell ◽  
Josiah D. Strawser ◽  
Alex Gottlieb ◽  
Michael H. Millonig ◽  
Frederick A. Hicks ◽  
...  
Keyword(s):  
Scale Up ◽  
Hydrogenation Reactions

scholarly journals New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants

2021 ◽  
Vol 75 (11) ◽  
pp. 948-956
Author(s):  
Thierry Furrer ◽  
Benedikt Müller ◽  
Christoph Hasler ◽  
Bernhard Berger ◽  
Michael K. Levis ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Process Model ◽  
Scale Up ◽  
Pilot Scale ◽  
Hydrogenation Reaction ◽  
Production Scale ◽  
Hydrogenation Reactions ◽  
Scale Down ◽  
Physical And Chemical ◽  
Scale Reactor

The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.

scholarly journals Scaling up a Gas-Phase Process for Converting Glycerol to Propane

Catalysts ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1007
Author(s):  
Christian Hulteberg ◽  
Andreas Leveau
Keyword(s):  
Catalyst Deactivation ◽  
Scale Up ◽  
Laboratory Data ◽  
Carbonaceous Material ◽  
Operating Mode ◽  
Water Mixture ◽  
Glycerol Water ◽  
Excess Hydrogen ◽  
Hydrogenation Reactions ◽  
Design Calculations

It is of interest to study not only the fundamental behavior of catalysts and reactors but also to ensure that they can be scaled up in size. This paper investigates the scale-up of a glycerol-to-propane process starting from fundamental laboratory data from micro-reactor testing to the kilogram scale. The process is described in detail and consist of the use of design documents and computer simulations for determining the sizes of the unit operations involved. The final design included a vaporizer section for a glycerol/water mixture, four reactors in tandem with subsequent dehydration and hydrogenation reactions, a flash vessel to separate the excess hydrogen used, and a compressor for recycling the excess hydrogen with additional light components. The system was commissioned in a linear fashion, which is described, and operated for more than 3000 h and more than 1000 h in the final operating mode including recycle. The major results were that no catalyst deactivation was apparent aside from the slow build-up of carbonaceous material in the first dehydration reactor. That the system design calculations proved to be quite close to the results achieved and that the data generated is believed to be sufficient for up-scaling the process into the 1000 to 10,000 tonnes-per-annum range.

NiAl precipitation in Fe-12w/o Cr-5w/o Ni-4w/o Al

1983 ◽  
Vol 41 ◽  
pp. 202-203
Author(s):  
L.E. Murr ◽  
J.S. Dunning ◽  
S. Shankar
Keyword(s):  
Solid Solution ◽  
Stainless Steel ◽  
Stainless Steels ◽  
Alloy Composition ◽  
Chromium Content ◽  
Scale Up ◽  
Optical Metallography ◽  
Property Evaluation ◽  
310 Stainless Steel ◽  
Microstructural Studies

Aluminum additions to conventional 18Cr-8Ni austenitic stainless steel compositions impart excellent resistance to high sulfur environments. However, problems are typically encountered with aluminum additions above about 1% due to embrittlement caused by aluminum in solid solution and the precipitation of NiAl. Consequently, little use has been made of aluminum alloy additions to stainless steels for use in sulfur or H2S environments in the chemical industry, energy conversion or generation, and mineral processing, for example.A research program at the Albany Research Center has concentrated on the development of a wrought alloy composition with as low a chromium content as possible, with the idea of developing a low-chromium substitute for 310 stainless steel (25Cr-20Ni) which is often used in high-sulfur environments. On the basis of workability and microstructural studies involving optical metallography on 100g button ingots soaked at 700°C and air-cooled, a low-alloy composition Fe-12Cr-5Ni-4Al (in wt %) was selected for scale up and property evaluation.

Scale-up of polyphenolic isolation by HPLC from Uncaria guianensis leaves by applying chromatographic models

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
RS Barboza ◽  
BR Rocha ◽  
AC Siani ◽  
LMM Valente ◽  
JL Mazzei
Keyword(s):  
Scale Up
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