Evaluation and Development of Practical Routes to an Enantiomerically Pure C2-Symmetric Diamine Building Block

2013 ◽  
Vol 17 (12) ◽  
pp. 1552-1560 ◽  
Author(s):  
Staffan Karlsson ◽  
Jan Lindberg ◽  
Henrik Sörensen
Keyword(s):  
Building Block ◽  
Enantiomerically Pure

scholarly journals Enantiomerically Pure [2.2]Paracyclophane-4-thiol: A Planar Chiral Sulfur-Based Building Block Readily Available by Resolution with an Amino Acid Chiral Auxiliary

2016 ◽  
Vol 81 (9) ◽  
pp. 3961-3966 ◽  
Author(s):  
Adrien Vincent ◽  
Damien Deschamps ◽  
Thomas Martzel ◽  
Jean-François Lohier ◽  
Christopher J. Richards ◽  
...  
Keyword(s):  
Amino Acid ◽  
Building Block ◽  
Chiral Auxiliary ◽  
Enantiomerically Pure

Synthesis of an Enantiomerically Pure Building Block for the Synthesis of Hydroporphyrins

2007 ◽  
Vol 2007 (2) ◽  
pp. 249-257 ◽  
Author(s):  
Genevieve Etornam Adukpo ◽  
Tobias Borrmann ◽  
René Manski ◽  
Rosa I. Sáez Díaz ◽  
Wolf-Dieter Stohrer ◽  
...  
Keyword(s):  
Building Block ◽  
Enantiomerically Pure

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

2019 ◽  
Vol 17 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Iaroslav Baglai ◽  
Michel Leeman ◽  
Richard M. Kellogg ◽  
Willem L. Noorduin
Keyword(s):  
Building Block ◽  
Rational Design ◽  
Large Scale ◽  
Enantiomerically Pure ◽  
Ripening Process ◽  
Simple Route ◽  
Chiral Component ◽  
Design And Application

A simple route to enantiomerically pure (S)-2-aminobutyramide – the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

(1R,3R)-1,3-Dimethyl-8-hydroxy-6- methoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride - an Enantiomerically Pure Building Block for the Synthesis of Naphthylisoquinoline Alkaloids

1995 ◽  
Vol 50 (7) ◽  
pp. 1137-1140 ◽  
Author(s):  
Karl Peters ◽  
Eva-Maria Peters ◽  
Gerhard Bringmann ◽  
Paul Anthony Keller ◽  
Manuela Schäffer
Keyword(s):  
Hydrogen Bonds ◽  
Building Block ◽  
Title Compound ◽  
Enantiomerically Pure ◽  
Orthorhombic System ◽  
Space Group ◽  
Naphthylisoquinoline Alkaloids

The title compound was prepared by hydrogenolytic deprotection of the corresponding Nbenzyl derivative, which had previously been synthesized by a Picted-Spengler condensation of the corresponding arylethylamine. It crystallizes from dichloromethane/methanol in the orthorhombic system, space group P212121 ; a = 1305.7(2), b = 1400.3(3), c = 727.4(1) pm. Hydrogen bonds between Cl and OH and NH2 groups cause a threedimensional arrangement.

scholarly journals Oxidative allylic rearrangement of cycloalkenols: Formal total synthesis of enantiomerically pure trisporic acid B

2011 ◽  
Vol 7 ◽  
pp. 421-425 ◽  
Author(s):  
Silke Dubberke ◽  
Muhammad Abbas ◽  
Bernhard Westermann
Keyword(s):  
Total Synthesis ◽  
Building Block ◽  
Building Blocks ◽  
Allylic Rearrangement ◽  
Reaction Sequence ◽  
Enantiomerically Pure ◽  
Quaternary Stereocenter

Enantiomerically highly enriched unsaturated β-ketoesters bearing a quaternary stereocenter can be utilized as building blocks for the synthesis of natural occurring terpenes, i. a., trisporic acid and its derivatives. An advanced building block has been synthesized in a short reaction sequence, which involves an oxidative allylic rearrangement initiated by pyridinium dichromate (PDC) as the key step.

Stereoselective Synthesis of 1′,2′-cis-Disubstituted Carbocyclic ribo-Nucleoside Analogues

Synthesis ◽  
2017 ◽  
Vol 50 (06) ◽  
pp. 1264-1274 ◽  
Author(s):  
Chris Meier ◽  
Simon Weising ◽  
Ilaria Torquati
Keyword(s):  
Building Block ◽  
Stereoselective Synthesis ◽  
Nucleoside Analogues ◽  
Convergent Synthesis ◽  
Enantiomerically Pure ◽  
Efficient Strategy ◽  
Asymmetric Dihydroxylation

Herein we disclose an efficient strategy for the convergent synthesis of 1′,2′-cis-disubstituted carbocyclic ribo-nucleoside analogues. Starting from an enantiomerically pure cyclopentenol precursor, the key step for the preparation of the highly functionalized carbocyclic building block is an asymmetric dihydroxylation. Employing different variants of the Mitsunobu protocol, the condensation with all-natural nucleobases or their precursors affords a series of ribo-configured carbocyclic 1′,2′-cis-disubstituted nucleoside analogues.

Enantiomerically Pure H-Arg(Z)2-aldehyde Diethylacetal: A Useful Building Block in the Synthesis of Peptide Aldehydes

2006 ◽  
pp. 218-219
Author(s):  
Fritz Dick ◽  
Juergen Gerhardt ◽  
Barbara Jakobi ◽  
Beat Sax ◽  
Joachim Schwindling ◽  
...  
Keyword(s):  
Building Block ◽  
Enantiomerically Pure ◽  
Peptide Aldehydes
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