Practical Nonazide Synthesis of a d-Amino Acid Oxidase Inhibitor via a Sequential Erlenmeyer–Plöchl Reaction and Ligand-Free Copper(I) Amination Protocol

Hang Zhao; Stefan G. Koenig; John W. Dankwardt; Surendra P. Singh

doi:10.1021/op4001737

Practical Nonazide Synthesis of a d-Amino Acid Oxidase Inhibitor via a Sequential Erlenmeyer–Plöchl Reaction and Ligand-Free Copper(I) Amination Protocol

Organic Process Research & Development ◽

10.1021/op4001737 ◽

2013 ◽

Vol 18 (1) ◽

pp. 198-204 ◽

Cited By ~ 7

Author(s):

Hang Zhao ◽

Stefan G. Koenig ◽

John W. Dankwardt ◽

Surendra P. Singh

Keyword(s):

Amino Acid ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Ligand Free

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Pharmacodynamic Effects of a d-Amino Acid Oxidase Inhibitor Indicate a Spinal Site of Action in Rat Models of Neuropathic Pain

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.113.204016 ◽

2013 ◽

Vol 345 (3) ◽

pp. 502-511 ◽

Cited By ~ 18

Author(s):

Seth C. Hopkins ◽

Fei-Yue Zhao ◽

Carrie A. Bowen ◽

Xin Fang ◽

Haifeng Wei ◽

...

Keyword(s):

Neuropathic Pain ◽

Amino Acid ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Rat Models ◽

Pharmacodynamic Effects ◽

Site Of Action

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A Kind of D-Amino Acid Oxidase Inhibitor, Sodium Benzoate, Might Relieve Panic Symptoms in a First-Episode, Drug-Naïve Panic-Disorder Patient

Journal of Neuropsychiatry ◽

10.1176/appi.neuropsych.12030075 ◽

2013 ◽

Vol 25 (2) ◽

pp. E07-E08 ◽

Cited By ~ 1

Author(s):

Yi-Cheng Hou ◽

Chien-Han Lai

Keyword(s):

Amino Acid ◽

Panic Disorder ◽

Sodium Benzoate ◽

Oxidase Inhibitor ◽

First Episode ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Disorder Patient ◽

Drug Naïve ◽

Panic Symptoms

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P.166 Safety, pharmacokinetics, and pharmacodynamics of TAK-831, a selective d-amino acid oxidase inhibitor, in healthy volunteers

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2019.09.212 ◽

2019 ◽

Vol 29 ◽

pp. S128-S129

Author(s):

E.M. Pich ◽

L. Xu ◽

J. Wu ◽

M. Asgharnejad ◽

M. Quinton S. ◽

...

Keyword(s):

Amino Acid ◽

Healthy Volunteers ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Pharmacokinetics And Pharmacodynamics ◽

Amino Acid Oxidase

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Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3- b ]pyrazine-2,3-dione as a novel potent d -amino acid oxidase inhibitor

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.04.017 ◽

2016 ◽

Vol 117 ◽

pp. 19-32 ◽

Cited By ~ 3

Author(s):

Dongsheng Xie ◽

Jun Lu ◽

Jin Xie ◽

Junjun Cui ◽

Teng-Fei Li ◽

...

Keyword(s):

Amino Acid ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Amino Acid Oxidase

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Local injection of D-amino acid oxidase inhibitor into the prefrontal cortex improves AD/HD-like behaviors of SHRSP/Ezo.

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.94.0_3-o-e4-4 ◽

2021 ◽

Vol 94 (0) ◽

pp. 3-O-E4-4

Author(s):

Hiroki Shikanai ◽

Tsugumi Shindo ◽

Sachiko Hiraide ◽

Kenji Iizuka ◽

Takeshi Izumi

Keyword(s):

Prefrontal Cortex ◽

Amino Acid ◽

Oxidase Inhibitor ◽

Local Injection ◽

Acid Oxidase ◽

Amino Acid Oxidase

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Efficacy and safety of add-on sodium benzoate, a D-amino Acid Oxidase Inhibitor, in treatment of schizophrenia: A systematic review and meta-analysis

Asian Journal of Psychiatry ◽

10.1016/j.ajp.2021.102947 ◽

2021 ◽

pp. 102947

Author(s):

Jyothsna Chinnapura Seetharam ◽

Rituparna Maiti ◽

Archana Mishra ◽

Biswa Ranjan Mishra

Keyword(s):

Systematic Review ◽

Amino Acid ◽

Sodium Benzoate ◽

Meta Analysis ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Efficacy And Safety ◽

Amino Acid Oxidase

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Predicting Protein-Ligand Interactions Based on Chemical Preference Features with its Application to New D-Amino Acid Oxidase Inhibitor Discovery

Current Pharmaceutical Design ◽

10.2174/1381612820666140306104823 ◽

2014 ◽

Vol 20 (32) ◽

pp. 5202-5211 ◽

Cited By ~ 1

Author(s):

Mingzhu Zhao ◽

Hao-Teng Chang ◽

Qiang Zhou ◽

Tao Zeng ◽

Chung-Shiuan Shih ◽

...

Keyword(s):

Amino Acid ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Protein Ligand Interactions ◽

Inhibitor Discovery ◽

Ligand Interactions

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Faculty Opinions recommendation of Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718168110.793488390 ◽

2013 ◽

Author(s):

Steven Potkin ◽

Adrian Preda

Keyword(s):

Amino Acid ◽

Controlled Trial ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Double Blind ◽

Double Blind Placebo

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In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c15-00867 ◽

2016 ◽

Vol 64 (7) ◽

pp. 695-703 ◽

Cited By ~ 6

Author(s):

Shohei Toguchi ◽

Tomoyasu Hirose ◽

Kazuko Yorita ◽

Kiyoshi Fukui ◽

K. Barry Sharpless ◽

...

Keyword(s):

Amino Acid ◽

Click Chemistry ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Amino Acid Oxidase

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Interactions of the potent d-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia

Neuropharmacology ◽

10.1016/j.neuropharm.2012.04.030 ◽

2012 ◽

Vol 63 (3) ◽

pp. 460-468 ◽

Cited By ~ 21

Author(s):

Nian Gong ◽

Yan-Chao Wang ◽

Hui-Li Wang ◽

Ai-Niu Ma ◽

Kenji Hashimoto ◽

...

Keyword(s):

Amino Acid ◽

Oxidase Inhibitor ◽

Acid Oxidase ◽

Amino Acid Oxidase

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