Improved Process for Ranolazine: An Antianginal Agent

2012 ◽  
Vol 16 (5) ◽  
pp. 748-754 ◽  
Author(s):  
Sampath Aalla ◽  
Goverdhan Gilla ◽  
Raghupathi Reddy Anumula ◽  
Srinivas Kurella ◽  
Pratap Reddy Padi ◽  
...  
Keyword(s):  
Antianginal Agent

scholarly journals Penetration of an antianginal agent, Nicorandil, into mitochondria of rat cardiomyocyte

2000 ◽  
Vol 82 ◽  
pp. 184
Author(s):  
Yoko Tsuchiya ◽  
Michitaka Akima ◽  
Keiji Saito ◽  
Nobuhiko Ishizuka ◽  
Shuzo Matsubara ◽  
...  
Keyword(s):  
Antianginal Agent

scholarly journals Nicorandil-Induced Hyperkalemia in a Uremic Patient

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Hung-Hao Lee ◽  
Po-Chao Hsu ◽  
Tsung-Hsien Lin ◽  
Wen-Ter Lai ◽  
Sheng-Hsiung Sheu
Keyword(s):  
Potassium Channel ◽  
Potassium Ions ◽  
Uremic Patient ◽  
Membrane Hyperpolarization ◽  
Voltage Gated ◽  
Antianginal Agent ◽  
Voltage Gated Calcium Channels ◽  
Detailed Evaluation ◽  
Potassium Channel Activator ◽  
Channel Activator

Nicorandil is an antianginal agent with nitrate-like and ATP-sensitive potassium channel activator properties. After activation of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of voltage-gated calcium channels, and finally vasodilation. We present a uremic case suffering from repeated junctional bradycardia, especially before hemodialysis. After detailed evaluation, nicorandil was suspected to be the cause of hyperkalemia which induced bradycardia. This case reminds us that physicians should be aware of this potential complication in patients receiving ATP-sensitive potassium channel activator.

scholarly journals Mechanism of action of a novel metabolically active antianginal agent (trimethazidine) delineated by PET

1996 ◽  
Vol 27 (2) ◽  
pp. 132 ◽  
Author(s):  
Freny Vaghalwalla Mody ◽  
Heinrich Schelbert ◽  
Kristine Coyle ◽  
Denis Buxton ◽  
Herbert Hansen ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Antianginal Agent

Profile of an Ideal Antianginal Agent

Drugs ◽  
1989 ◽  
Vol 38 (Supplement 2) ◽  
pp. 1-8 ◽  
Author(s):  
Eliot J. Lazar ◽  
William H. Frishman
Keyword(s):  
Antianginal Agent

Pharmacokinetic and pharmacodynamic studies in man with an antianginal agent ‘Visacor’

1990 ◽  
Vol 11 (3) ◽  
pp. 253-263
Author(s):  
Ian D. Cockshott ◽  
James McAinsh ◽  
Stephanie Norris
Keyword(s):  
Antianginal Agent

scholarly journals Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties

Circulation ◽  
2004 ◽  
Vol 110 (8) ◽  
pp. 904-910 ◽  
Author(s):  
Charles Antzelevitch ◽  
Luiz Belardinelli ◽  
Andrew C. Zygmunt ◽  
Alexander Burashnikov ◽  
José M. Di Diego ◽  
...  
Keyword(s):  
Antianginal Agent ◽  
Electrophysiological Effects
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