Efficient Preparation of a Key Intermediate in the Synthesis of Roxifiban by Enzymatic Dynamic Kinetic Resolution on Large Scale¶

2004 ◽  
Vol 8 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Jaan A. Pesti ◽  
Jinguao Yin ◽  
Lin-hua Zhang ◽  
Luigi Anzalone ◽  
Robert E. Waltermire ◽  
...  
Keyword(s):  
Large Scale ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

scholarly journals Development of dynamic kinetic resolution on large scale for (±)-1-phenylethylamine

2010 ◽  
Vol 6 ◽  
pp. 823-829 ◽  
Author(s):  
Lisa K Thalén ◽  
Jan-E Bäckvall
Keyword(s):  
Good Yield ◽  
Large Scale ◽  
Kinetic Resolution ◽  
Catalyst Loading ◽  
Acyl Donor ◽  
Dynamic Kinetic Resolution ◽  
Reaction Parameters ◽  
Ru Catalyst ◽  
Isopropyl Acetate ◽  
Acyl Donors

Candida antarctica lipase B (CALB) and racemization catalyst 4 were combined in the dynamic kinetic resolution (DKR) of (±)-1-phenylethylamine (1). Several reaction parameters have been investigated to modify the method for application on multigram scale. A comparison of isopropyl acetate and alkyl methoxyacetates as acyl donors was carried out. It was found that lower catalyst loadings could be used to obtain (R)-2-methoxy-N-(1-phenylethyl)acetamide (3) in good yield and high ee when alkyl methoxyacetates were used as acyl donors compared to when isopropyl acetate was used as the acyl donor. The catalyst loading could be decreased to 1.25 mol % Ru-catalyst 4 and 10 mg CALB per mmol 1 when alkyl methoxyacetates were used as the acyl donor.

Development of a Robust and Highly Selective Ru(II)-Catalyzed Dynamic Kinetic Resolution Used to Manufacture AMG 232

2020 ◽  
Vol 24 (6) ◽  
pp. 1164-1174
Author(s):  
Austin G. Smith ◽  
Matthew M. Bio ◽  
John T. Colyer ◽  
Khalid Diker ◽  
Gilles Gorins ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides

2021 ◽  
Author(s):  
Linghui Qian ◽  
Ling-Fei Tao ◽  
Wen-Tao Wang ◽  
Ehtesham Jameel ◽  
Zhang-Hong Luo ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Efforts towards a Noyori reduction of a 3-fluorpiperidin-4-one with dynamic kinetic resolution

2021 ◽  
pp. 152764
Author(s):  
Jacques Le Paih ◽  
Dane A. Goff ◽  
Rajinder Singh ◽  
Simon J. Shaw
Keyword(s):  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution
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