In Situ Recycling of Chiral Ligand and Surplus Nucleophile for a Noncatalytic Reaction:  Amplification of Process Throughput in the Asymmetric Addition Step of Efavirenz (DMP 266)

2003 ◽  
Vol 7 (3) ◽  
pp. 324-328 ◽  
Author(s):  
Anusuya Choudhury ◽  
James R. Moore ◽  
Michael E. Pierce ◽  
Joseph M. Fortunak ◽  
Ioannis Valvis ◽  
...  
Keyword(s):  
Chiral Ligand ◽  
Asymmetric Addition ◽  
Noncatalytic Reaction ◽  
Reaction Amplification

scholarly journals Molecular Characterization of hobo-Mediated Inversions in Drosophila melanogaster

Genetics ◽  
1996 ◽  
Vol 144 (2) ◽  
pp. 647-656
Author(s):  
William B Eggleston ◽  
Nac R Rim ◽  
Johng K Lim
Keyword(s):  
X Chromosome ◽  
Polymerase Chain Reaction Amplification ◽  
Polytene Chromosomes ◽  
Chromosomal Inversions ◽  
Hobo Element ◽  
Reaction Amplification ◽  
Notch Locus ◽  
Polymerase Chain

Abstract The structure of chromosomal inversions mediated by hobo transposable elements in the Uc-1 X chromosome was investigated using cytogenetic and molecular methods. Uc-1 contains a phenotypically silent hobo element inserted in an intron of the Notch locus. Cytological screening identified six independent Notch mutations resulting from chromosomal inversions with one breakpoint at cytological position 3C7, the location of Notch. In situ hybridization to salivary gland polytene chromosomes determined that both ends of each inversion contained hobo and Notch sequences. Southern blot analyses showed that both breakpoints in each inversion had hobo-Notch junction fragments indistinguishable in structure from those present in the Uc-1 X chromosome prior to the rearrangements. Polymerase chain reaction amplification of the 12 hobo-Notch junction fragments in the six inversions, followed by DNA sequence analysis, determined that each was identical to one of the two hobo-Notch junctions present in Uc-1. These results are consistent with a model in which hobo-mediated inversions result from homologous pairing and recombination between a pair of hobo elements in reverse orientation.

Synthesis of Solution-Phase Phosphoramidite and Phosphite Ligand Libraries and Their In Situ Screening in the Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids

2007 ◽  
Vol 9 (3) ◽  
pp. 407-414 ◽  
Author(s):  
Richard B. C. Jagt ◽  
Patrick Y. Toullec ◽  
Ebe P. Schudde ◽  
Johannes G. de Vries ◽  
Ben L. Feringa ◽  
...  
Keyword(s):  
Solution Phase ◽  
Asymmetric Addition ◽  
Arylboronic Acids

ChemInform Abstract: Catalytic Asymmetric Addition of Meldrum′s Acid, Malononitrile, and 1,3-Dicarbonyls to ortho-Quinone Methides Generated in situ under Basic Conditions.

ChemInform ◽  
2015 ◽  
Vol 46 (35) ◽  
pp. no-no
Author(s):  
Lorenzo Caruana ◽  
Martina Mondatori ◽  
Vasco Corti ◽  
Sara Morales ◽  
Andrea Mazzanti ◽  
...  
Keyword(s):  
Quinone Methides ◽  
Asymmetric Addition ◽  
Catalytic Asymmetric

A new pyrrolidine-derived atropisomeric amino alcohol as a highly efficient chiral ligand for the asymmetric addition of diethylzinc to aldehydes

2014 ◽  
Vol 55 (50) ◽  
pp. 6891-6894 ◽  
Author(s):  
Ferenc Faigl ◽  
Zsuzsa Erdélyi ◽  
Szilvia Deák ◽  
Miklós Nyerges ◽  
Béla Mátravölgyi
Keyword(s):  
Amino Alcohol ◽  
Chiral Ligand ◽  
Asymmetric Addition ◽  
Highly Efficient

Structural requirements of a chiral ligand for the catalytic asymmetric addition of thiophenol to α,β-unsaturated esters

1998 ◽  
Vol 39 (15) ◽  
pp. 2141-2144 ◽  
Author(s):  
Kiyoshi Tomioka ◽  
Manabu Okuda ◽  
Katsumi Nishimura ◽  
Shino Manabe ◽  
Motomu Kanai ◽  
...  
Keyword(s):  
Chiral Ligand ◽  
Structural Requirements ◽  
Asymmetric Addition ◽  
Unsaturated Esters ◽  
Catalytic Asymmetric
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