An Efficient Large-Scale Process for the Human Leukocyte Elastase Inhibitor, DMP 7771

2002 ◽  
Vol 6 (1) ◽  
pp. 54-63 ◽  
Author(s):  
Louis Storace ◽  
Luigi Anzalone ◽  
Pat N. Confalone ◽  
Wayne P. Davis ◽  
Joseph M. Fortunak ◽  
...  
Keyword(s):  
Large Scale ◽  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Human Leukocyte Elastase

scholarly journals Isolation and Characterization of Guamerin, a New Human Leukocyte Elastase Inhibitor fromHirudo nipponia

1995 ◽  
Vol 270 (23) ◽  
pp. 13879-13884 ◽  
Author(s):  
Hyo Il Jung ◽  
Seung Il Kim ◽  
Kwon-Soo Ha ◽  
Cheol O Joe ◽  
Ke Won Kang
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Isolation And Characterization ◽  
Human Leukocyte Elastase

Preformulation Development of a Human Leukocyte Elastase Inhibitor for Oral Dosage

1996 ◽  
Vol 22 (2) ◽  
pp. 77-83
Author(s):  
Daryl M. Simmons ◽  
Chaoying Zhang ◽  
Robert W. Lee ◽  
Jon R. Swanson
Keyword(s):  
Human Leukocyte ◽  
Oral Dosage ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Human Leukocyte Elastase

ChemInform Abstract: An Asymmetric Synthesis of L-694,458, a Human Leukocyte Elastase Inhibitor, via Novel Enzyme Resolution of β-Lactam Esters.

ChemInform ◽  
2010 ◽  
Vol 28 (6) ◽  
pp. no-no
Author(s):  
R. J. CVETOVICH ◽  
M. CHARTRAIN ◽  
F. W. JUN. HARTNER ◽  
C. ROBERGE ◽  
J. S. AMATO ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Human Leukocyte Elastase

Human Leukocyte Elastase and Cathepsin G Inactivate Factor VII by Limited Proteolysis

1993 ◽  
Vol 70 (03) ◽  
pp. 414-417 ◽  
Author(s):  
Trude Anderssen ◽  
Hanne Halvorsen ◽  
S Paul Bajaj ◽  
Bjarne Østerud
Keyword(s):  
Polyacrylamide Gel Electrophoresis ◽  
Limited Proteolysis ◽  
Human Leukocyte ◽  
Cathepsin G ◽  
Factor Vii ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Human Leukocyte Elastase ◽  
Coagulant Activity

SummaryThe effect of supernatant from phorbol myristate acetate (PMA) stimulated human polymorphonuclear granulocytes (PMN) on human factor VII was studied in vitro. The supernatant caused a rapid loss in factor VII coagulant activity by the action of human leukocyte elastase (HLE) and cathepsin G in the supernatant, as demonstrated by the use of specific inhibitors of the two serine proteases, respectively. Preincubation of the supernatant with the elastase inhibitor and the cathepsin G inhibitor preserved 80% and 25% of the clotting activity, respectively. Calcium protected factor VII completely from the supernatant mediated inactivation. Cathepsin G and HLE purified from PMN each destroyed the coagulant activity of factor VII when added to a non-plasma system. There were, however, no effect on factor VII activity when cathepsin G was added to plasma. Polyacrylamide gel electrophoresis in the presence of SDS indicated that HLE and cathepsin G cleaved the zymogen in the same manner, producing (a) peptide(s) of low molecular mass and a single large product of 48 kDa. Preincubation of factor VII with calcium ions inhibited the proteolytic action of HLE and cathepsin G. It is suggested that HLE and cathepsin G from activated granulocytes may be partly responsible for the loss in factor VII activity that is observed during sepsis.

scholarly journals Trivaric Acid, a Potent Depside Human Leukocyte Elastase Inhibitor

2012 ◽  
Vol 35 (12) ◽  
pp. 2247-2251 ◽  
Author(s):  
Zhihui Zheng ◽  
Shen Zhang ◽  
Xinhua Lu ◽  
Ying Ma ◽  
Yuling Fan ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Human Leukocyte Elastase

The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats

2008 ◽  
Vol 8 (7) ◽  
pp. 959-966 ◽  
Author(s):  
Yun Ju Jo ◽  
Ho Soon Choi ◽  
Dae Won Jun ◽  
Oh Young Lee ◽  
Joo Seop Kang ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Human Leukocyte Elastase

A novel human leukocyte elastase inhibitor from duck egg white

1996 ◽  
Vol 32 (1-3) ◽  
pp. 108-110
Author(s):  
Tatyana A. Valueva ◽  
Galina V. Kladnitskaya ◽  
Vladimir V. Mosolov
Keyword(s):  
Human Leukocyte ◽  
Egg White ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Human Leukocyte Elastase ◽  
Duck Egg
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