[(N,N-Dimethylamino)carboxymethylene]pentacarbonylchromium(0):  The First Fischer Carbene Complex with a Free Carboxyl Group Attached Directly to the Carbene Atom

1998 ◽  
Vol 17 (16) ◽  
pp. 3627-3629 ◽  
Author(s):  
Dalimil Dvořák ◽  
Miroslav Ludwig
Keyword(s):  
Carboxyl Group ◽  
Carbene Complex ◽  
Fischer Carbene ◽  
Free Carboxyl

scholarly journals Catalytic Diversity of GH30 Xylanases

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4528
Author(s):  
Katarína Šuchová ◽  
Vladimír Puchart ◽  
Nikolaj Spodsberg ◽  
Kristian B. R. Mørkeberg Krogh ◽  
Peter Biely
Keyword(s):  
Methyl Ester ◽  
Catalytic Properties ◽  
Specific Activity ◽  
Current Knowledge ◽  
Carboxyl Group ◽  
Weak Effect ◽  
Bacterial Enzymes ◽  
Catalytic Activities ◽  
Almost All ◽  
Free Carboxyl

Catalytic properties of GH30 xylanases belonging to subfamilies 7 and 8 were compared on glucuronoxylan, modified glucuronoxylans, arabinoxylan, rhodymenan, and xylotetraose. Most of the tested bacterial GH30-8 enzymes are specific glucuronoxylanases (EC 3.2.1.136) requiring for action the presence of free carboxyl group of MeGlcA side residues. These enzymes were not active on arabinoxylan, rhodymenan and xylotetraose, and conversion of MeGlcA to its methyl ester or its reduction to MeGlc led to a remarkable drop in their specific activity. However, some GH30-8 members are nonspecific xylanases effectively hydrolyzing all tested substrates. In terms of catalytic activities, the GH30-7 subfamily is much more diverse. In addition to specific glucuronoxylanases, the GH30-7 subfamily contains nonspecific endoxylanases and predominantly exo-acting enzymes. The activity of GH30-7 specific glucuronoxylanases also depend on the presence of the MeGlcA carboxyl, but not so strictly as in bacterial enzymes. The modification of the carboxyl group of glucuronoxylan had only weak effect on the action of predominantly exo-acting enzymes, as well as nonspecific xylanases. Rhodymenan and xylotetraose were the best substrates for exo-acting enzymes, while arabinoxylan represented hardly degradable substrate for almost all tested GH30-7 enzymes. The results expand current knowledge on the catalytic properties of this relatively novel group of xylanases.

Indoline Derivatives Containing a Free Carboxyl Group and a Sulfamide Fragment in Position 5

ChemInform ◽  
2005 ◽  
Vol 36 (8) ◽  
Author(s):  
E. E. Shalygina ◽  
M. Yu. Solovyov ◽  
K. V. Balakin ◽  
S. A. Ivanovskii ◽  
M. V. Dorogov
Keyword(s):  
Carboxyl Group ◽  
Free Carboxyl

Esterification of the free carboxylic group from the lutidinic acid ligand as a tool to improve the cytotoxicity of Ru(ii) complexes

2019 ◽  
Vol 6 (2) ◽  
pp. 376-390 ◽  
Author(s):  
João Honorato ◽  
Legna Colina-Vegas ◽  
Rodrigo S. Correa ◽  
Adriana P. M. Guedes ◽  
Marcelo Miyata ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cellular Uptake ◽  
Ruthenium Complexes ◽  
Carboxyl Group ◽  
Carboxylic Group ◽  
Complex Interactions ◽  
Acid Ligand ◽  
Free Carboxyl

The esterification of the free carboxyl group in ruthenium complexes improves the complex interactions with biomolecules, lipophilicity, and cellular uptake, making them more selective against tumor cells than cisplatin.

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