Role of 1,2-Dimethoxyethane in the Transformation from Ethylene Polymerization to Trimerization Using Chromium Tris(2-ethylhexanoate)-Based Catalyst System: A DFT Study

2010 ◽  
Vol 29 (7) ◽  
pp. 1588-1602 ◽  
Author(s):  
Yuan Qi ◽  
Qi Dong ◽  
Lei Zhong ◽  
Zhen Liu ◽  
Pengyuan Qiu ◽  
...  
Keyword(s):  
Ethylene Polymerization ◽  
Catalyst System ◽  
Dft Study ◽  
System A

The SORS Decision-Making Support System: A statistical tool for better policy making in the Republic of Serbia

2021 ◽  
pp. 1-11
Author(s):  
Miladin Kovačević ◽  
Katarina Stančić
Keyword(s):  
Policy Making ◽  
Modern Society ◽  
Monitoring And Evaluation ◽  
Public Debate ◽  
Statistical Tool ◽  
The Public ◽  
System A ◽  
The Republic ◽  
Trusted Data

Modern society is witnessing a data revolution which necessarily entails changes to the overall behavior of citizens, governments and companies. This is a big challenge and an opportunity for National Statistics Offices (NSOs). Especially after the outbreak of COVID-19, when the public debate about the number of mortalities and tested and infected persons escalated, trusted data is required more than ever. Which data can modern society trust? Are modern societies being subjected to opinion rather than fact? This paper introduces a new statistical tool to facilitate policy-making based on trusted statistics. Using economic indicators to illustrate implementation, the new statistical tool is shown to be a flexible instrument for analysis, monitoring and evaluation of the economic situation in the Republic of Serbia. By taking a role in public policy management, the tool can be used to transform the NSO’s role in the statistical system into an active participant in public debate in contrast to the previous traditional, usually passive role of collecting, processing and publishing data. The tool supports the integration of statistics into public policies and connects the knowledge and expertise of official statisticians on one side with political decision makers on the other.

scholarly journals Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins

2021 ◽  
Vol 18 (8) ◽  
pp. 3962
Author(s):  
Azahara María García-Serna ◽  
Elena Martín-Orozco ◽  
Trinidad Hernández-Caselles ◽  
Eva Morales
Keyword(s):  
Immune System ◽  
Immune Cell ◽  
Mode Of Delivery ◽  
Environmental Influences ◽  
Pet Ownership ◽  
System A ◽  
Neonatal Immune System ◽  
Chemical Factors ◽  
Asthma And Allergy

It is suggested that programming of the immune system starts before birth and is shaped by environmental influences acting during critical windows of susceptibility for human development. Prenatal and perinatal exposure to physiological, biological, physical, or chemical factors can trigger permanent, irreversible changes to the developing immune system, which may be reflected in cord blood of neonates. The aim of this narrative review is to summarize the evidence on the role of the prenatal and perinatal environment, including season of birth, mode of delivery, exposure to common allergens, a farming environment, pet ownership, and exposure to tobacco smoking and pollutants, in shaping the immune cell populations and cytokines at birth in humans. We also discuss how reported disruptions in the immune system at birth might contribute to the development of asthma and related allergic manifestations later in life.

scholarly journals The Relevance of the SH2 Domain for c-Src Functionality in Triple-Negative Breast Cancer Cells

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 462
Author(s):  
Víctor Mayoral-Varo ◽  
María Pilar Sánchez-Bailón ◽  
Annarica Calcabrini ◽  
Marta García-Hernández ◽  
Valerio Frezza ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Sh2 Domain ◽  
Model Systems ◽  
System A ◽  
Promising Therapeutic Target ◽  
Relevant Role ◽  
Inactivating Mutation

The role of Src family kinases (SFKs) in human tumors has been always associated with tyrosine kinase activity and much less attention has been given to the SH2 and SH3 adapter domains. Here, we studied the role of the c-Src-SH2 domain in triple-negative breast cancer (TNBC). To this end, SUM159PT and MDA-MB-231 human cell lines were employed as model systems. These cells conditionally expressed, under tetracycline control (Tet-On system), a c-Src variant with point-inactivating mutation of the SH2 adapter domain (R175L). The expression of this mutant reduced the self-renewal capability of the enriched population of breast cancer stem cells (BCSCs), demonstrating the importance of the SH2 adapter domain of c-Src in the mammary gland carcinogenesis. In addition, the analysis of anchorage-independent growth, proliferation, migration, and invasiveness, all processes associated with tumorigenesis, showed that the SH2 domain of c-Src plays a very relevant role in their regulation. Furthermore, the transfection of two different aptamers directed to SH2-c-Src in both SUM159PT and MDA-MB-231 cells induced inhibition of their proliferation, migration, and invasiveness, strengthening the hypothesis that this domain is highly involved in TNBC tumorigenesis. Therefore, the SH2 domain of c-Src could be a promising therapeutic target and combined treatments with inhibitors of c-Src kinase enzymatic activity may represent a new therapeutic strategy for patients with TNBC, whose prognosis is currently very negative.

The Role of the Governor-General in Ceylon

1968 ◽  
Vol 2 (3) ◽  
pp. 193-220 ◽  
Author(s):  
A. Jeyaratnam Wilson
Keyword(s):  
Economic Growth ◽  
Slow Rate ◽  
Heterogeneous Population ◽  
Political Behaviour ◽  
System A ◽  
Caste Groups

Ceylon is one of the few non-European members of the Commonwealth which has been reasonably successful in adapting the Westminster-style government to suit its own requirements. There are difficulties in operating the system—a heterogeneous population comprising religious, cultural, linguistic and caste groups whose differences are not seldom accentuated by the island's slow rate of economic growth—but despite these, it could be said from the experience of nearly twenty years of Parliament's working, that the willingness of parties and groups to differ on a constitutional plane with all the necessary corollaries of elections, political meetings, a legally established government and a recognized opposition is the generally accepted norm of political behaviour in Ceylon today.

scholarly journals Acetylene and Ethylene Adsorption on a β-Mo2C(100) Surface: A Periodic DFT Study on the Role of C- and Mo-Terminations for Bonding and Hydrogenation Reactions

2017 ◽  
Vol 121 (36) ◽  
pp. 19786-19795 ◽  
Author(s):  
Carlos Jimenez-Orozco ◽  
Elizabeth Florez ◽  
Andres Moreno ◽  
Ping Liu ◽  
José A. Rodriguez
Keyword(s):  
Dft Study ◽  
Ethylene Adsorption ◽  
Hydrogenation Reactions ◽  
Periodic Dft

EPR spectroscopic study of Ni(I) species in the catalyst system for ethylene polymerization based on α-diimine Ni(II) complex activated by MMAO

2019 ◽  
Vol 880 ◽  
pp. 267-271 ◽  
Author(s):  
Igor E. Soshnikov ◽  
Nina V. Semikolenova ◽  
Konstantin P. Bryliakov ◽  
Artem A. Antonov ◽  
Wen-Hua Sun ◽  
...  
Keyword(s):  
Spectroscopic Study ◽  
Ethylene Polymerization ◽  
Catalyst System
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