Design, Synthesis, and Structural Characterization of Molecular and Supramolecular Heterobimetallic Metallamacrocycles Based on the 1,1‘-Bis(4-pyridyl)ferrocene (Fe(η5-C5H4-1-C5H4N)2) Ligand

2003 ◽  
Vol 22 (22) ◽  
pp. 4532-4538 ◽  
Author(s):  
Dario Braga ◽  
Marco Polito ◽  
Daniela D'Addari ◽  
Emilio Tagliavini ◽  
Davide M. Proserpio ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Design Synthesis

Design, synthesis, and three-dimensional structural characterization of a constrained Ω-loop excised from interleukin-1α

Tetrahedron ◽  
1993 ◽  
Vol 49 (17) ◽  
pp. 3629-3640 ◽  
Author(s):  
Ramakanth Sarabu ◽  
Kathleen Lovey ◽  
Vincent S. Madison ◽  
David C. Fry ◽  
David N. Greeley ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Three Dimensional ◽  
Design Synthesis ◽  
Interleukin 1Α

ChemInform Abstract: Ring-Closing Metathesis of Olefinic Peptides: Design, Synthesis, and Structural Characterization of Macrocyclic Helical Peptides.

ChemInform ◽  
2010 ◽  
Vol 32 (46) ◽  
pp. no-no
Author(s):  
Helen E. Blackwell ◽  
Jack D. Sadowsky ◽  
Rebecca J. Howard ◽  
Joshua N. Sampson ◽  
Jeffery A. Chao ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Ring Closing Metathesis ◽  
Helical Peptides ◽  
Design Synthesis

Design, Synthesis, and Structural Characterization of a New Class of Ferrocene-Containing Heterometallic Triple-Stranded Helicates

2012 ◽  
Vol 32 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Muthukrishna Raja ◽  
Ratnasabapathy G. Iyer ◽  
Chengeto Gwengo ◽  
Daniel L. Reger ◽  
Perry J. Pellechia ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Design Synthesis ◽  
New Class

Ring-Closing Metathesis of Olefinic Peptides:  Design, Synthesis, and Structural Characterization of Macrocyclic Helical Peptides

2001 ◽  
Vol 66 (16) ◽  
pp. 5291-5302 ◽  
Author(s):  
Helen E. Blackwell ◽  
Jack D. Sadowsky ◽  
Rebecca J. Howard ◽  
Joshua N. Sampson ◽  
Jeffery A. Chao ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Ring Closing Metathesis ◽  
Helical Peptides ◽  
Design Synthesis

Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide

2019 ◽  
Vol 30 (7) ◽  
pp. 1998-2010 ◽  
Author(s):  
Kyriakos Gabriel Varnava ◽  
Sk. Abdul Mohid ◽  
Paolo Calligari ◽  
Lorenzo Stella ◽  
Jóhannes Reynison ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Design Synthesis ◽  
Derivatives Of ◽  
Antibacterial Potential

Aminimides as Potential CNS Acting Agents. II Design, Synthesis, and Receptor Binding of 4′-Arylalkyl Aminimide Analogues of Clozapine as Prospective Novel Antipsychotics

2008 ◽  
Vol 61 (1) ◽  
pp. 5 ◽  
Author(s):  
Ben Capuano ◽  
Ian T. Crosby ◽  
Edward J. Lloyd ◽  
Juliette E. Neve ◽  
David A. Taylor
Keyword(s):  
Atypical Antipsychotic ◽  
Receptor Binding ◽  
Structural Characterization ◽  
Marked Reduction ◽  
Second Generation ◽  
Functional Group ◽  
Design Synthesis ◽  
Biochemical Effects ◽  
Antipsychotic Activity

We report the synthesis of a series of second generation aminimide-based analogues of clozapine, investigating the length of the linker between the aminimide functional group and the introduced aryl moiety. The chemistry and structural characterization of this series of 4′-arylalkyl aminimide analogues of clozapine are described. Preliminary findings on the biochemical effects of linker length and type of aryl moiety on affinity for dopamine D4 and serotonin 5-HT2A receptors are discussed. All of the compounds showed a marked reduction in binding at the two receptors when compared with clozapine, thus showing a reduced potential for atypical antipsychotic activity.

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