Stability of Methyl Platinum Complexes in Water:  The Role of pH and Geometry

2003 ◽  
Vol 22 (4) ◽  
pp. 826-833 ◽  
Author(s):  
Derrick W. Lucey ◽  
Derrik S. Helfer ◽  
Jim D. Atwood
Keyword(s):  
Platinum Complexes

The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine

2010 ◽  
Vol 45 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Francisco J. Ramos-Lima ◽  
Victoria Moneo ◽  
Adoración G. Quiroga ◽  
Amancio Carnero ◽  
Carmen Navarro-Ranninger
Keyword(s):  
Platinum Complexes ◽  
Cellular Toxicity

Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand

2013 ◽  
Vol 42 (37) ◽  
pp. 13343 ◽  
Author(s):  
Cecilia Martín Santos ◽  
Silvia Cabrera ◽  
Carla Ríos-Luci ◽  
José M. Padrón ◽  
Isabel López Solera ◽  
...  
Keyword(s):  
Platinum Complexes ◽  
Hydroxyl Group

scholarly journals Gold as a Possible Alternative to Platinum-Based Chemotherapy for Colon Cancer Treatment

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 780 ◽  
Author(s):  
Inés Mármol ◽  
Javier Quero ◽  
María Jesús Rodríguez-Yoldi ◽  
Elena Cerrada
Keyword(s):  
Gold Nanoparticles ◽  
Side Effects ◽  
Platinum Complexes ◽  
Tumor Resistance ◽  
Promising Alternative ◽  
Platinum Based Chemotherapy ◽  
Traditional Therapies ◽  
Efficient Uptake ◽  
Novel Therapeutic Strategies

Due to the increasing incidence and high mortality associated with colorectal cancer (CRC), novel therapeutic strategies are urgently needed. Classic chemotherapy against CRC is based on oxaliplatin and other cisplatin analogues; however, platinum-based therapy lacks selectivity to cancer cells and leads to deleterious side effects. In addition, tumor resistance to oxaliplatin is related to chemotherapy failure. Gold(I) derivatives are a promising alternative to platinum complexes, since instead of interacting with DNA, they target proteins overexpressed on tumor cells, thus leading to less side effects than, but a comparable antitumor effect to, platinum derivatives. Moreover, given the huge potential of gold nanoparticles, the role of gold in CRC chemotherapy is not limited to gold(I) complexes. Gold nanoparticles have been found to be able to overcome multidrug resistance along with reduced side effects due to a more efficient uptake of classic drugs. Moreover, the use of gold nanoparticles has enhanced the effect of traditional therapies such as radiotherapy, photothermal therapy, or photodynamic therapy, and has displayed a potential role in diagnosis as a consequence of their optic properties. Herein, we have reviewed the most recent advances in the use of gold(I) derivatives and gold nanoparticles in CRC therapy.

Strategy to enhance the anticancer efficacy of X-ray radiotherapy in melanoma cells by platinum complexes, the role of ROS-mediated signaling pathways

2014 ◽  
Vol 354 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Qiang Xie ◽  
Guoqiang Lan ◽  
Yangliang Zhou ◽  
Jiamin Huang ◽  
Yuanwei Liang ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Platinum Complexes ◽  
Melanoma Cells ◽  
Anticancer Efficacy ◽  
X Ray
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