Platinum and palladium complexes of bicyclo[3.3.1]non-1-ene. Bonding and reactions of strained olefin-transition metal complexes

1985 ◽  
Vol 4 (2) ◽  
pp. 296-302 ◽  
Author(s):  
Stephen A. Godleski ◽  
Kurt B. Gundlach ◽  
Richard S. Valpey
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Palladium Complexes ◽  
Platinum And Palladium Complexes

scholarly journals Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2860
Author(s):  
Robert Czarnomysy ◽  
Dominika Radomska ◽  
Anna Muszyńska ◽  
Justyna Magdalena Hermanowicz ◽  
Izabela Prokop ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transition Metal ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Transition Metal Complexes ◽  
Breast Cancer Cells ◽  
Palladium Complexes ◽  
Anticancer Activities ◽  
Platinum And Palladium Complexes ◽  
Mcf 7

Novel transition metal complexes (Au, Pd, Pt) with berenil and 2-(1-methyl-5-nitroimidazol-2-yl)ethanol were obtained through two-step synthesis. The cytotoxicity assay against MCF-7 and MDA-MB-231 breast cancer cells revealed that novel platinum and palladium complexes cause a reduction on the viability of MCF-7 and MDA-MB-231 breast cancer cells to a greater extent than cisplatin. The complexes showed lower cytotoxicity on normal MCF-10A human breast epithelial cells than on tumor cells. Furthermore, we observed that these complexes selectively concentrate in tumor cell mitochondria due to the characteristic for these cells increased membrane potential that may explain their increased proapoptotic activity. The activity of the synthesized compounds against topoisomerase type IIα and their increased impact on DNA defragmentation also were documented. The novel complexes also induced autophagosome changes and inhibited tumor growth in xenograft models (established using breast cancer cells).

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