Transition-metal-promoted activation of carbon-carbon bonds. A new synthetic route to substituted ruthenocene derivatives via ring expansion reactions of 3-vinyl-1-cyclopropenes

1989 ◽  
Vol 8 (4) ◽  
pp. 1015-1019 ◽  
Author(s):  
Russell P. Hughes ◽  
David J. Robinson
Keyword(s):  
Transition Metal ◽  
Ring Expansion ◽  
Synthetic Route ◽  
Carbon Carbon Bonds ◽  
Carbon Bonds

scholarly journals Synthesis of 2-oxindoles via 'transition-metal-free' intramolecular dehydrogenative coupling (IDC) of sp2 C–H and sp3 C–H bonds

2016 ◽  
Vol 12 ◽  
pp. 1153-1169 ◽  
Author(s):  
Nivesh Kumar ◽  
Santanu Ghosh ◽  
Subhajit Bhunia ◽  
Alakesh Bisai
Keyword(s):  
Transition Metal ◽  
Alkyl Halides ◽  
One Pot ◽  
Metal Free ◽  
Quaternary Center ◽  
Dehydrogenative Coupling ◽  
Carbon Carbon Bonds ◽  
Carbon Bonds

The synthesis of a variety of 2-oxindoles bearing an all-carbon quaternary center at the pseudo benzylic position has been achieved via a ‘transition-metal-free’ intramolecular dehydrogenative coupling (IDC). The construction of 2-oxindole moieties was carried out through formation of carbon–carbon bonds using KOt-Bu-catalyzed one pot C-alkylation of β-N-arylamido esters with alkyl halides followed by a dehydrogenative coupling. Experimental evidences indicated toward a radical-mediated path for this reaction.

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