The Pattern of Fluorine Substitution Affects Binding Affinity in a Small Library of Fluoroaromatic Inhibitors for Carbonic Anhydrase

1999 ◽  
Vol 1 (2) ◽  
pp. 183-186 ◽  
Author(s):  
Jeffrey B. Doyon ◽  
Ahamindra Jain
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Affinity ◽  
Fluorine Substitution

scholarly journals Modulating the Efficacy of Carbonic Anhydrase Inhibitors through Fluorine Substitution

2021 ◽  
Author(s):  
Emanuela Berrino ◽  
Bastien Michelet ◽  
Agnes Martin-Mingot ◽  
Claudiu Supuran ◽  
Sebastien Thibaudeau
Keyword(s):  
Carbonic Anhydrase ◽  
Fluorine Substitution ◽  
Carbonic Anhydrase Inhibitors

Binding affinity of substituted ureido-benzenesulfonamide ligands to the carbonic anhydrase receptor: A theoretical study of enzyme inhibition

2013 ◽  
Vol 34 (22) ◽  
pp. 1907-1916 ◽  
Author(s):  
Chandan Sahu ◽  
Kaushik Sen ◽  
Srimanta Pakhira ◽  
Bhaskar Mondal ◽  
Abhijit K. Das
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Affinity ◽  
Enzyme Inhibition ◽  
Theoretical Study

Thermodynamic Stability of Carbonic Anhydrase:  Measurements of Binding Affinity and Stoichiometry Using ThermoFluor

Biochemistry ◽  
2005 ◽  
Vol 44 (13) ◽  
pp. 5258-5266 ◽  
Author(s):  
Daumantas Matulis ◽  
James K. Kranz ◽  
F. Raymond Salemme ◽  
Matthew J. Todd
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Affinity ◽  
Thermodynamic Stability

Protein Surface-Assisted Enhancement in the Binding Affinity of an Inhibitor for Recombinant Human Carbonic Anhydrase-II

2004 ◽  
Vol 126 (35) ◽  
pp. 10875-10883 ◽  
Author(s):  
Abir L. Banerjee ◽  
Michael Swanson ◽  
Bidhan C. Roy ◽  
Xiao Jia ◽  
Manas K. Haldar ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Affinity ◽  
Carbonic Anhydrase Ii ◽  
Protein Surface ◽  
Human Carbonic Anhydrase

scholarly journals An efficient strategy to enhance binding affinity and specificity of a known isozyme inhibitor

2016 ◽  
Vol 14 (28) ◽  
pp. 6833-6839 ◽  
Author(s):  
Joo-Eun Jee ◽  
Jaehong Lim ◽  
Yong Siang Ong ◽  
Jessica Oon ◽  
Liqian Gao ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Affinity ◽  
High Throughput ◽  
High Throughput Screening ◽  
Peptide Libraries ◽  
Binding Profile ◽  
Efficient Strategy

The binding profile of a known inhibitor, benzenesulfonamide, against a family of carbonic anhydrase isozymes was efficiently enhanced via high-throughput screening of customized combinatorial one-bead-one-compound peptide libraries.

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