Cu(I)-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes Bearing a Primary or Secondary Amino Group in Alcoholic Solvents

2009 ◽  
Vol 11 (10) ◽  
pp. 2145-2147 ◽  
Author(s):  
Hirohisa Ohmiya ◽  
Toshimitsu Moriya ◽  
Masaya Sawamura
Keyword(s):  
Amino Group ◽  
Secondary Amino

Amino Acid Salt Catalyzed Asymmetric Addition Reaction of Acetylacetone to Maleimides and 2-(2-Oxoindolin-3-ylidene)malononitriles

Synlett ◽  
2019 ◽  
Vol 30 (10) ◽  
pp. 1241-1245 ◽  
Author(s):  
Haiyan Wu ◽  
Hongxin Liu ◽  
Juan Li ◽  
Xinhua Li ◽  
Hong-Ping Xiao ◽  
...  
Keyword(s):  
Amino Acid ◽  
Addition Reaction ◽  
Optical Purity ◽  
Activation Mechanism ◽  
Amino Group ◽  
Acid Salt ◽  
Natural Amino Acid ◽  
Catalytic Potential ◽  
Amino Acid Salt ◽  
Secondary Amino

The exploration of catalytic potential of natural amino acid salt in activation of 1,3-dicarbonyls was carried out, in which maleimides and 2-(2-oxoindolin-3-ylidene)malononitriles were found to be good electrophiles and afforded the desired products with excellent yield and moderate optical purity. Control experiments showed that the secondary amino group of barium (S)-prolinate is critical to the catalytic activity as well as enantiocontrol, thus revealed an enamine activation mechanism is possible in the present methodology.

Metal derivatives of amide oximes. III. Products of the reaction between dialkyldichlorosilanes and amide oximes

1974 ◽  
Vol 27 (11) ◽  
pp. 2319 ◽  
Author(s):  
AB Goel ◽  
VD Gupta
Keyword(s):  
Infrared Spectra ◽  
Amino Group ◽  
Monomeric Form ◽  
Metal Derivatives ◽  
Secondary Amino ◽  
Derivatives Of

The reaction of dialkyldichlorosilanes with amide oximes leads to cyclic products whose monomeric form has an l-oxa-3,5-diaza-2-silacyclopent-4-ene structure. These compounds exist mostly in adimeric form, occasionally monomeric or trimeric. Their infrared spectra have been interpreted. The secondary amino group of the compounds has been trisilylated.

ANNOTININE: THE REACTIONS OF THE CYCLIC ETHER FUNCTION

1954 ◽  
Vol 32 (3) ◽  
pp. 268-279 ◽  
Author(s):  
H. L. Meier ◽  
P. D. Meister ◽  
Léo Marion
Keyword(s):  
Chromic Acid ◽  
Cyclic Ether ◽  
The Other ◽  
Amino Group ◽  
Imino Group ◽  
Unsaturated Lactone ◽  
Clemmensen Reduction ◽  
Secondary Amino ◽  
Concentrated Solution ◽  
Chromous Chloride

Treatment of annotinine chlorohydrin with chromous chloride has been found to produce not only the already reported unsaturated lactone A (C16H21O2N), but also a second unsaturated lactone B (C16H21(23)O2N), and a hydroxylactone (C16H23O3N). Under the action of a concentrated solution of the same reagent the hydroxylactone is converted to the unsaturated lactone B. On hydrogenation the latter gives a dihydrolactone B which seems to contain a secondary amino group. Annotinine hydrate on treatment with thionyl chloride gives an unsaturated chlorolactone (C16H20O2NCl) which can be hydrogenated and subsequently dechlorinated to produce a third lactone C, different from either of dihydrolactones A or B, but which like the latter seems to contain an imino group. Oxidation of annotinine hydrate with chromic acid produces a hydroxyketone which can be converted into an oxime and, therefore, one of the hydroxyls of the hydrate is secondary while the other is probably tertiary. On the other hand, oxidation of annotinine with potassium permanganate gives rise to a lactam which by the Clemmensen reduction is converted to a mixture of lactam chlorohydrin and dihydrolactone A.

REACTION OF TRICHLOROACETONITRILE WITH PRIMARY AND SECONDARY AMINES: PART II. INFRARED SPECTRA OF N-SUBSTITUTED TRICHLOROACETAMIDINES

1959 ◽  
Vol 37 (4) ◽  
pp. 795-802 ◽  
Author(s):  
John C. Grivas ◽  
Alfred Taurins
Keyword(s):  
Infrared Spectra ◽  
Secondary Amines ◽  
Amino Group ◽  
Polar Solvents ◽  
Primary And Secondary Amines ◽  
Secondary Amino ◽  
Solid Phases ◽  
Infrared Absorption Spectra ◽  
Degree Of Association ◽  
Liquid And Solid Phases

A correlation between the infrared absorption spectra and the structure of 13 N-mono- and N-di-substituted trichloroacetamidines is presented. N-Alkyl- and N-aryl-trichloroacetami-dines associate strongly in the liquid and solid phases, and exist only in the imino form in non-polar solvents. They can be characterized by a strong band (amidine II band) at 1510–1525 cm−1 and 1570–1580 cm−1 respectively which is attributed to the deformation vibration [Formula: see text] of the secondary amino group. The degree of association of N-substituted trichloroacetamidines changes in the following order of substitution:[Formula: see text]

scholarly journals New 4-iminohydantoin sulfamide derivatives with antiviral and anticancer activity

2021 ◽  
Vol 16 (1) ◽  
pp. 10-17
Author(s):  
Yurii Kornii ◽  
Oleh Shablykin ◽  
Olga Shablykina ◽  
Volodymyr Brovarets
Keyword(s):  
Amino Acids ◽  
Anticancer Activity ◽  
Carboxylic Acids ◽  
Human Cytomegalovirus ◽  
Methyl Esters ◽  
Amino Group ◽  
Secondary Amino

A number of sulfamides were obtained by reaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and anticancer activity of new derivatives was evaluated. The most effective compounds against Human cytomegalovirus were sulfamides based on anisidine (1b), N-Boc-piperazine (1h), and the derivatives 1n,o with fragments of nipecotic and azetidine-3-carboxylic acids, respectively. Anticancer activity was most significant for sulfamides based on p-methoxybenzylamine (compound 1d), benzylmethylamine (compound 1f), and allylmethylamine (compound 1g).

Sign in / Sign up

Export Citation Format

Share Document