Improved Asymmetric Synthesis of 3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol, a Potent Cholesteryl Ester Transfer Protein Inhibitor

Thomas A. Rano; Gee-Hong Kuo

doi:10.1021/ol900639j

Improved Asymmetric Synthesis of 3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol, a Potent Cholesteryl Ester Transfer Protein Inhibitor

Organic Letters ◽

10.1021/ol900639j ◽

2009 ◽

Vol 11 (13) ◽

pp. 2812-2815 ◽

Cited By ~ 20

Author(s):

Thomas A. Rano ◽

Gee-Hong Kuo

Keyword(s):

Cholesteryl Ester ◽

Asymmetric Synthesis ◽

Cholesteryl Ester Transfer Protein ◽

Protein Inhibitor ◽

Transfer Protein

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Asymmetric Synthesis of the Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib

Organic Process Research & Development ◽

10.1021/op060013i ◽

2006 ◽

Vol 10 (3) ◽

pp. 472-480 ◽

Cited By ~ 50

Author(s):

David B. Damon ◽

Robert W. Dugger ◽

Stephen E. Hubbs ◽

Jill M. Scott ◽

Robert W. Scott

Keyword(s):

Cholesteryl Ester ◽

Asymmetric Synthesis ◽

Cholesteryl Ester Transfer Protein ◽

Protein Inhibitor ◽

Transfer Protein

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Faculty Opinions recommendation of Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1097533.553610 ◽

2007 ◽

Author(s):

Rhian Touyz

Keyword(s):

Blood Pressure ◽

Phase I ◽

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Ambulatory Blood Pressure ◽

Healthy Individuals ◽

Protein Inhibitor ◽

Double Blind ◽

Phase I Studies ◽

Transfer Protein

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Faculty Opinions recommendation of Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1148081.605196 ◽

2009 ◽

Author(s):

Anders Olsson

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Efficacy And Safety ◽

Protein Inhibitor ◽

Transfer Protein

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Design, synthesis and biological evaluation of N,N-3-phenyl-3-benzylaminopropanamide derivatives as novel cholesteryl ester transfer protein inhibitor

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.12.010 ◽

2016 ◽

Vol 24 (8) ◽

pp. 1589-1597 ◽

Cited By ~ 6

Author(s):

Dongmei Zhao ◽

Honglei Xie ◽

Changlin Bai ◽

Chunchi Liu ◽

Chenzhou Hao ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Biological Evaluation ◽

Protein Inhibitor ◽

Design Synthesis ◽

Transfer Protein ◽

Synthesis And Biological Evaluation

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Efficacy and safety after cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib (MK-0859) in patients with primary hypercholesterolemia or mixed hyperlipidemia

American Heart Journal ◽

10.1016/j.ahj.2011.07.010 ◽

2011 ◽

Vol 162 (4) ◽

pp. 708-716 ◽

Cited By ~ 22

Author(s):

Hayes M. Dansky ◽

Daniel Bloomfield ◽

Patrice Gibbons ◽

Sherry Liu ◽

Christine McCrary Sisk ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Efficacy And Safety ◽

Protein Inhibitor ◽

Primary Hypercholesterolemia ◽

Transfer Protein ◽

Mixed Hyperlipidemia ◽

Cessation Of Treatment

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Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib and Off-Target Toxicity

Circulation ◽

10.1161/circulationaha.108.772665 ◽

2008 ◽

Vol 118 (24) ◽

pp. 2515-2522 ◽

Cited By ~ 115

Author(s):

Menno Vergeer ◽

Michiel L. Bots ◽

Sander I. van Leuven ◽

Dick C. Basart ◽

Eric J. Sijbrands ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Protein Inhibitor ◽

Transfer Protein

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Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients

American Heart Journal ◽

10.1016/j.ahj.2008.09.022 ◽

2009 ◽

Vol 157 (2) ◽

pp. 352-360.e2 ◽

Cited By ~ 191

Author(s):

Daniel Bloomfield ◽

Gary L. Carlson ◽

Aditi Sapre ◽

Diane Tribble ◽

James M. McKenney ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Efficacy And Safety ◽

Protein Inhibitor ◽

Transfer Protein

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Iterative Cyclopropanation: A Concise Strategy for the Total Synthesis of the Hexacyclopropane Cholesteryl Ester Transfer Protein Inhibitor U-106305

Journal of the American Chemical Society ◽

10.1021/ja9708326 ◽

1997 ◽

Vol 119 (37) ◽

pp. 8608-8615 ◽

Cited By ~ 36

Author(s):

Anthony G. M. Barrett ◽

Dieter Hamprecht ◽

Andrew J. P. White ◽

David J. Williams

Keyword(s):

Total Synthesis ◽

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Protein Inhibitor ◽

Transfer Protein

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Abstract: P1392 EFFECTS OF THE CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR ANACETRAPIB ON LIPOPROTEIN SUBFRACTIONS

Atherosclerosis Supplements ◽

10.1016/s1567-5688(09)71400-x ◽

2009 ◽

Vol 10 (2) ◽

pp. e1442 ◽

Cited By ~ 1

Author(s):

R Krauss ◽

K Wojnoonski ◽

JC Geaney ◽

R Kimberlin ◽

A Johnson-Levonas ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Protein Inhibitor ◽

Lipoprotein Subfractions ◽

Transfer Protein

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Pharmacokinetics, Metabolism, and Excretion of Torcetrapib, a Cholesteryl Ester Transfer Protein Inhibitor, in Humans

Drug Metabolism and Disposition ◽

10.1124/dmd.108.023176 ◽

2008 ◽

Vol 36 (11) ◽

pp. 2185-2198 ◽

Cited By ~ 38

Author(s):

Deepak Dalvie ◽

Weichao Chen ◽

Chenghong Zhang ◽

Alfin D. Vaz ◽

Teresa A. Smolarek ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Protein Inhibitor ◽

Transfer Protein

Download Full-text