Microwave-Assisted Palladium-Catalyzed Cross-Coupling of Aryl and Vinyl Halides with H-Phosphonate Diesters

2008 ◽  
Vol 10 (20) ◽  
pp. 4637-4640 ◽  
Author(s):  
Marcin Kalek ◽  
Asraa Ziadi ◽  
Jacek Stawinski
Keyword(s):  
Cross Coupling ◽  
Vinyl Halides ◽  
Microwave Assisted ◽  
Palladium Catalyzed

Palladium Catalyzed Synthesis of Phenylquinoxaline-Alkyne Derivatives via Sonogashira Cross Coupling Reaction

2021 ◽  
Vol 43 (1) ◽  
pp. 95-95
Author(s):  
Rifhat Bibi Rifhat Bibi ◽  
Muhammad Yaseen Muhammad Yaseen ◽  
Haseen Ahmad Haseen Ahmad ◽  
Ismat Ullah Khan Ismat Ullah Khan ◽  
Shaista Parveen Shaista Parveen ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Sonogashira Reaction ◽  
Terminal Alkynes ◽  
Vinyl Halides ◽  
Sonogashira Coupling Reaction ◽  
Quinoxaline Derivatives ◽  
Palladium Catalyzed ◽  
High Yields ◽  
Alkyne Derivatives

Transition metals mediated cross coupling methodologies provide an extremely powerful versatile pathway in organic syntheses undoubtedly, a facile route for syntheses and derivatization of biologically important heterocycles from easily available precursors. Sonogashira coupling reaction, a leading method to Csp-Csp2 bond formation is one of the most important and rapid pathways to couple aryl/vinyl halides with terminal alkynes. Current research study deals with the synthesis of alkyne substituted quinoxaline derivatives. The quinoxalines class of aromatic heterocycles exhibits a wide variety of important biological potencies. Palladium catalyzed cross coupling process provided an effective synthetic practice for the synthesis of alkyne derivatives of quinoxaline. Vareity of terminal alkynes were coupled with 2-(4-bromophenyl)quinoxaline under optimized conditions for Sonogashira reaction, affording alkyne substituted quinoxaline derivatives in high yields. The optimized reaction conditions for coupling of range of terminal alkyne with quinoxaline basic core render this process significant for designing of medicinally interesting precursors.

ChemInform Abstract: Efficient Microwave-Assisted Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactins in 5-Nitroimidazole Series.

ChemInform ◽  
2010 ◽  
Vol 41 (6) ◽  
Author(s):  
Maxime D. Crozet ◽  
Laura Zink ◽  
Vincent Remusat ◽  
Christophe Curti ◽  
Patrice Vanelle
Keyword(s):  
Cross Coupling ◽  
Microwave Assisted ◽  
Palladium Catalyzed

scholarly journals B-N Bond Formation through Palladium-Catalyzed, Microwave-Assisted Cross-Coupling of Nitrogen Compounds with Iodo-dodecaborate

2021 ◽  
Author(s):  
Mahmoud Al-Joumhawy ◽  
Tarek Marei ◽  
Akim Shmalko ◽  
Paula Cendoya ◽  
Jair La Borde ◽  
...  
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Nitrogen Compounds ◽  
Microwave Assisted ◽  
Palladium Catalyzed ◽  
Potential Use

Substituted undecahydrido-closo-dodecaborates [B12H11NR2]2- have potential use in materials and drugs, but have presented a synthetic challenge. Microwave-assisted palladium-catalyzed amination of iodo-dodecaborate [B12H11I]2- allows mild and reproducible formation of B-N bonds...

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