scholarly journals Diastereoselective Synthesis of Cyclopentapyridazinones via Radical Cyclization: Synthetic Studies Toward Halichlorine

2008 ◽  
Vol 10 (21) ◽  
pp. 4783-4786 ◽  
Author(s):  
Gary E. Keck ◽  
Stacey A. Heumann
Keyword(s):  
Radical Cyclization ◽  
Diastereoselective Synthesis ◽  
Synthetic Studies

Synthetic studies on cyathin diterpenes - Total synthesis of (±)-allocyathin B3

2004 ◽  
Vol 82 (2) ◽  
pp. 254-267 ◽  
Author(s):  
Dale E Ward ◽  
Yuanzhu Gai ◽  
Qi Qiao ◽  
Jianheng Shen
Keyword(s):  
Total Synthesis ◽  
Ring System ◽  
Radical Cyclization ◽  
Isopropyl Group ◽  
Hydroxymethyl Group ◽  
Relative Stereochemistry ◽  
Synthetic Studies ◽  
Vinyl Triflate

The synthesis of racemic allocyathin B3 from an advanced intermediate possessing the ring system and relative stereochemistry but lacking the isopropyl and hydroxymethyl groups is reported. The isopropyl group was introduced by radical cyclization of a methyl propargyl acetal of an α-bromoketone and the hydroxymethyl group was generated by Pd-catalyzed carbonylation of a vinyl triflate. The route provides functionalized intermediates that could allow access to more complex members of the cyathin family of diterpenes. Several modifications and improvements to the procedures previously described for the synthesis of the advanced intermediate have been achieved.Key words: cyathin diterpenes, cyathanes, allocyathin B3.

Synthetic Studies on the Role of Substituents at C-3 Position on C3-C4 Bond Cleavage of β-Lactam Ring: Convenient Route for Diastereoselective Synthesis of Pyridin-2-ones

Heterocycles ◽  
2012 ◽  
Vol 86 (2) ◽  
pp. 1301 ◽  
Author(s):  
Mohinder P. Mahajan ◽  
Pardeep Singh ◽  
Parvesh Singh ◽  
Kewal Kumar ◽  
Vipan Kumar ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Diastereoselective Synthesis ◽  
Lactam Ring ◽  
Convenient Route ◽  
Synthetic Studies
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