Total Synthesis of Aristolactams via a One-Pot Suzuki−Miyaura Coupling/Aldol Condensation Cascade Reaction

2008 ◽  
Vol 10 (16) ◽  
pp. 3543-3546 ◽  
Author(s):  
Joa Kyum Kim ◽  
Young Ha Kim ◽  
Ho Tae Nam ◽  
Bum Tae Kim ◽  
Jung-Nyoung Heo
Keyword(s):  
Total Synthesis ◽  
Aldol Condensation ◽  
Cascade Reaction ◽  
One Pot

ChemInform Abstract: Total Synthesis of Aristolactams via a One-Pot Suzuki-Miyaura Coupling/Aldol Condensation Cascade Reaction.

ChemInform ◽  
2008 ◽  
Vol 39 (51) ◽  
Author(s):  
Joa Kyum Kim ◽  
Young Ha Kim ◽  
Ho Tae Nam ◽  
Bum Tae Kim ◽  
Jung-Nyoung Heo
Keyword(s):  
Total Synthesis ◽  
Aldol Condensation ◽  
Cascade Reaction ◽  
One Pot

First total synthesis of oteromycin utilizing one-pot four-step cascade reaction strategy

2013 ◽  
Vol 54 (6) ◽  
pp. 506-511 ◽  
Author(s):  
Hiromi Uchiro ◽  
Nobuhiro Shionozaki ◽  
Ryo Tanaka ◽  
Hiroyuki Kitano ◽  
Naoki Iwamura ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cascade Reaction ◽  
One Pot

Direct One-Pot Synthesis of Phenanthrenes via Suzuki−Miyaura Coupling/Aldol Condensation Cascade Reaction

2008 ◽  
Vol 73 (2) ◽  
pp. 495-501 ◽  
Author(s):  
Young Ha Kim ◽  
Hyuk Lee ◽  
Yeong Joon Kim ◽  
Bum Tae Kim ◽  
Jung-Nyoung Heo
Keyword(s):  
Aldol Condensation ◽  
Cascade Reaction ◽  
One Pot ◽  
One Pot Synthesis

Total synthesis of (+)-UCS1025A based on a sequential Michael-retro Michael strategy featuring one-pot six-step cascade reaction

2018 ◽  
Vol 59 (8) ◽  
pp. 704-707 ◽  
Author(s):  
Ryota Sano ◽  
Ryo Kosuge ◽  
Tetsu Tsubogo ◽  
Hiromi Uchiro
Keyword(s):  
Total Synthesis ◽  
Cascade Reaction ◽  
One Pot

ChemInform Abstract: Direct One-Pot Synthesis of Phenanthrenes via Suzuki-Miyaura Coupling/Aldol Condensation Cascade Reaction.

ChemInform ◽  
2008 ◽  
Vol 39 (20) ◽  
Author(s):  
Young Ha Kim ◽  
Hyuk Lee ◽  
Yeong Joon Kim ◽  
Bum Tae Kim ◽  
Jung-Nyoung Heo
Keyword(s):  
Aldol Condensation ◽  
Cascade Reaction ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals An active and stable multifunctional catalyst with defective UiO-66 as a support for Pd over the continuous catalytic conversion of acetone and hydrogen

RSC Advances ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 48-56
Author(s):  
Yingjie Hu ◽  
Yuxin Mei ◽  
Baining Lin ◽  
Xuhong Du ◽  
Fan Xu ◽  
...  
Keyword(s):  
Methyl Isobutyl Ketone ◽  
Aldol Condensation ◽  
Catalytic Conversion ◽  
Cascade Reaction ◽  
Methyl Isobutyl ◽  
Isobutyl Ketone ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Multifunctional Catalyst

The one-pot synthesis of methyl isobutyl ketone (MIBK) and methyl isobutyl methanol (MIBC) from acetone and hydrogen is a typical cascade reaction comprised of aldol condensation-dehydration-hydrogenation.

First Total Synthesis of 27-deoxylyngbyabellin A

Synthesis ◽  
2021 ◽  
Author(s):  
Yang Zhang ◽  
Yi Liu ◽  
Yuguo Du
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Secondary Metabolite ◽  
Building Block ◽  
Aldol Reaction ◽  
Cascade Reaction ◽  
Hydroxy Ester ◽  
Marine Cyanobacteria ◽  
One Pot ◽  
Key Steps

In this study, we documented the first total synthesis of marine cyanobacteria secondary metabolite 27-deoxylyngbyabellin A in 10 linear steps with 9.7% overall yield. Key steps entailed (1) one-pot cascade reaction of (S)-2-(benzyloxy)-3-methylbutanoic acid and Boc-Ile-Thz-OMe with the building block β-azido disulfide 7 to access the critical thiazole units 3 and 4, (2) chiral oxazaborolidinone-mediated asymmetry aldol reaction to construct (S)-β-hydroxy ester 5, and (3) DPPA-mediated macrolactamization of linear precursor 2 to achieve the natural product 27-deoxylyngbyabellin A.

A One-Pot Chemoenzymatic Synthesis of (2S,4R)-4-Methylproline Enables the First Total Synthesis of Antiviral Lipopeptide Cavinafungin B

2018 ◽  
Author(s):  
Christian R. Zwick ◽  
Hans Renata
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Complex Molecule ◽  
Molecular Target ◽  
Chemoenzymatic Synthesis ◽  
General Strategy ◽  
One Pot

We report an efficient ten-step synthesis of antiviral natural product cavinafungin B in 37% overall yield. By leveraging a one-pot chemoenzymatic synthesis of (2S,4R)-4-methylproline and oxazolidine-tethered (Rink-Boc-ATG-resin) SPPS methodology, the assembly of our molecular target could be conducted in an efficient manner.This general strategy could prove amenable to the construction of other natural and unnatural linear lipopeptides. The value of incorporating biocatalytic steps in complex molecule synthesis is highlighted by this work.

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