Continuous Flow Synthesis of Chiral Amines in Organic Solvents: Immobilization of E. coli Cells Containing Both ω-Transaminase and PLP

2014 ◽  
Vol 16 (23) ◽  
pp. 6092-6095 ◽  
Author(s):  
Leandro H. Andrade ◽  
Wolfgang Kroutil ◽  
Timothy F. Jamison
Keyword(s):  
Organic Solvents ◽  
Continuous Flow ◽  
Chiral Amines ◽  
Flow Synthesis ◽  
E Coli

scholarly journals Immobilized Whole-Cell Transaminase Biocatalysts for Continuous-Flow Kinetic Resolution of Amines

Catalysts ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 438 ◽  
Author(s):  
Zsófia Molnár ◽  
Emese Farkas ◽  
Ágnes Lakó ◽  
Balázs Erdélyi ◽  
Wolfgang Kroutil ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Kinetic Resolution ◽  
Sol Gel ◽  
Chiral Amines ◽  
Flow Mode ◽  
Immobilized Cell ◽  
Hollow Silica ◽  
E Coli ◽  
Sol Gel Process ◽  
Racemic Amines

Immobilization of transaminases creates promising biocatalysts for production of chiral amines in batch or continuous-flow mode reactions. E. coli cells containing overexpressed transaminases of various selectivities and hollow silica microspheres as supporting agent were immobilized by an improved sol-gel process to produce immobilized transaminase biocatalysts with suitable stability and mechanical properties for continuous-flow applications. The immobilized cell-based transaminase biocatalyst proved to be durable and easy-to-use in kinetic resolution of four racemic amines 1a–d. The batch and continuous-flow mode kinetic resolutions with transaminase biocatalyst of opposite stereopreference provided access to both enantiomers of the corresponding amines. By using the most suitable immobilized transaminase biocatalysts, this study describes the first transaminase-based approach for the production of both pure enantiomers of 1-(3,4-dimethoxyphenyl)ethan-1-amine 1d.

Continuous flow synthesis of the lamivudine precursor L-Menthyl Glyoxylate

2021 ◽  
Author(s):  
Lais S. D. Azevedo ◽  
Anderson R. Aguillon ◽  
Marcelo T. Lima ◽  
Raquel A. C. Leão ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

Continuous Flow Synthesis of Persistent Luminescent Chromium-Doped Zinc Gallate Nanoparticles

2021 ◽  
pp. 7067-7075
Author(s):  
Xiaojun Wei ◽  
Stephen V. Kershaw ◽  
Xiaodan Huang ◽  
Mingxia Jiao ◽  
Chau Chun Beh ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Zinc Gallate

scholarly journals Continuous flow synthesis of azoxybenzenes by reductive dimerization of nitrosobenzenes with gel‐bound catalysts

2021 ◽  
Author(s):  
Carsten J. Schmiegel ◽  
Patrik Berg ◽  
Franziska Obst ◽  
Roland Schoch ◽  
Dietmar Appelhans ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Reductive Dimerization

scholarly journals Continuous Flow Synthesis of Metal–NHC Complexes**

2021 ◽  
Vol 27 (18) ◽  
pp. 5653-5657 ◽  
Author(s):  
Andreas Simoens ◽  
Thomas Scattolin ◽  
Thibault Cauwenbergh ◽  
Gianmarco Pisanò ◽  
Catherine S. J. Cazin ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

scholarly journals Continuous‐Flow Synthesis of High‐Quality Few‐Layer Antimonene Hexagons

2021 ◽  
pp. 2101616
Author(s):  
Iñigo Torres ◽  
Marta Alcaraz ◽  
Roger Sanchis‐Gual ◽  
Jose A. Carrasco ◽  
Michael Fickert ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Quality ◽  
Flow Synthesis

scholarly journals Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 303
Author(s):  
András Gy. Németh ◽  
Renáta Szabó ◽  
György Orsy ◽  
István M. Mándity ◽  
György M. Keserű ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Simple Filtration

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

scholarly journals Continuous‐Flow Synthesis of ZIF‐8 Biocomposites with Tunable Particle Size

2020 ◽  
Vol 59 (21) ◽  
pp. 8123-8127 ◽  
Author(s):  
Francesco Carraro ◽  
Jason D. Williams ◽  
Mercedes Linares‐Moreau ◽  
Chiara Parise ◽  
Weibin Liang ◽  
...  
Keyword(s):  
Particle Size ◽  
Continuous Flow ◽  
Flow Synthesis

A microfluidic impedance biosensor based on immunomagnetic separation and urease catalysis for continuous-flow detection of E. coli O157:H7

2018 ◽  
Vol 259 ◽  
pp. 1013-1021 ◽  
Author(s):  
Lan Yao ◽  
Lei Wang ◽  
Fengchun Huang ◽  
Gaozhe Cai ◽  
Xinge Xi ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Immunomagnetic Separation ◽  
E Coli ◽  
Flow Detection

scholarly journals Nanofiltration-Enabled In Situ Solvent and Reagent Recycle for Sustainable Continuous-Flow Synthesis

ChemSusChem ◽  
2017 ◽  
Vol 10 (17) ◽  
pp. 3435-3444 ◽  
Author(s):  
Tamas Fodi ◽  
Christos Didaskalou ◽  
Jozsef Kupai ◽  
Gyorgy T. Balogh ◽  
Peter Huszthy ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis
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